Circulating inflammatory cytokines and female reproductive diseases: a Mendelian randomization analysis

doi:10.1210/clinem/dgad376

科研成果详情

题名	Circulating inflammatory cytokines and female reproductive diseases: a Mendelian randomization analysis
作者	Lin, Yiting 1,2; Wang, Guiquan 3; Li, Yan1; Yang, Haiyan1; Zhao, Yue 4,5,6,7; Liu, Jun 8; Mu, Liangshan 2
发表日期	2023-12
发表期刊	The Journal of clinical endocrinology and metabolism 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Cytokines Drug target Female reproductive diseases Inflammation Mendelian randomization
其他关键词	COLONY-STIMULATING FACTOR ; ECTOPIC PREGNANCY ; RECEPTOR ; PROLIFERATION ; ENDOMETRIOSIS ; MECHANISMS ; EXPRESSION ; VARIANTS ; OVARY
摘要	Extensive studies have provided considerable evidence suggesting the role of inflammation in the development of female reproductive diseases. However, the causality isn't established., To explore whether genetically determined circulating levels of cytokines are causally associated with female reproductive diseases and discover potential novel drug targets for these diseases., Instrumental variables (IVs) for 47 circulating cytokines were obtained from a genome-wide association study (GWAS) meta-analysis of 31,112 European individuals. Protein quantitative trait loci and expression quantitative trait loci close to genes served as our IVs. Summary data of nine female reproductive diseases were mainly derived from GWAS meta-analysis of the UK biobank and FinnGen. We elevated the association using the Wald ratio or inverse-variance-weighted Mendelian randomization (MR) with subsequent assessments for MR assumptions in several sensitivity and colocalization analyses. We consider FDR < 0.05 as statistical significance in MR analyses. Replication studies were conducted for further validation, and phenome-wide association studies were designed to explore potential side effects., Our results indicated that high levels of macrophage colony-stimulating factor (MCSF), growth-regulated oncogene-alpha (GROα), and soluble intercellular adhesion molecule-1 were associated with increased risks of endometriosis, female infertility, and pre-eclampsia, respectively. High platelet-derived growth factor-BB (PDGF-BB) levels that reduced the risk of ovarian aging were also supported. Replication analysis supported the relationship between GROα and female infertility, and between MCSF and endometriosis., We identified four correlated pairs that implied potential protein drug targets. Notably, we preferred highlighting the value of PDGF-BB as a drug target for ovarian ageing, and MCSF as a drug target for endometriosis.
资助项目	Ministry of Science and Technology of the Peoples's Republic of China [2021YFC2700402]; Peking University Third Hospital [BYSY2022043]
出版者	ENDOCRINE SOC
ISSN	0021-972X
EISSN	1945-7197
卷号	108 期号:12 页码:3154-3164
DOI	10.1210/clinem/dgad376
页数	11
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001170653700001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-06
URL	查看原文
PubMed ID	37350485
SCOPUSEID	2-s2.0-85170096800
通讯作者地址	[Mu, Liangshan]Center for Reproductive Medicine,Zhongshan Hospital,Fudan University,No. 180 Fenglin Road, Xuhui District,Shanghai,200032,China ; [Zhao, Yue]Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,No.49 North HuaYuan Road, HaiDian District,Beijing,100191,China ; [Liu, Jun]Nuffield Department of Population Health,University of Oxford,Oxford,Oxford,OX37LF,United Kingdom
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Biochemistry;Endocrinology;Clinical Biochemistry;Biochemistry (medical)
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181205
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院附属第一医院_生殖医学中心
通讯作者	Zhao, Yue; Liu, Jun; Mu, Liangshan
作者单位	1.Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Reproductive Medicine Center,Zhongshan Hospital,Fudan University,Shanghai,China; 3.Center for Reproductive Medicine,Women and Children’s Hospital,School of Medicine,Xiamen University,Xiamen,China; 4.Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing,China; 5.National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital),Beijing,China; 6.Key Laboratory of Assisted Reproduction,Ministry of Education,Beijing,China; 7.Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology,Beijing,China; 8.Nuffield Department of Population Health,University of Oxford,Oxford,United Kingdom
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 生殖医学中心
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Lin, Yiting,Wang, Guiquan,Li, Yan,et al. Circulating inflammatory cytokines and female reproductive diseases: a Mendelian randomization analysis[J]. The Journal of clinical endocrinology and metabolism,2023,108(12):3154-3164.
APA	Lin, Yiting., Wang, Guiquan., Li, Yan., Yang, Haiyan., Zhao, Yue., ... & Mu, Liangshan. (2023). Circulating inflammatory cytokines and female reproductive diseases: a Mendelian randomization analysis. The Journal of clinical endocrinology and metabolism, 108(12), 3154-3164.
MLA	Lin, Yiting,et al."Circulating inflammatory cytokines and female reproductive diseases: a Mendelian randomization analysis".The Journal of clinical endocrinology and metabolism 108.12(2023):3154-3164.