Supplementation with Nicotinamide riboside attenuates T cell exhaustion and improves survival in sepsis

doi:10.1097/SHK.0000000000002153

科研成果详情

题名	Supplementation with Nicotinamide riboside attenuates T cell exhaustion and improves survival in sepsis
作者	Zhao, Guang-Ju1,2; Yang, Xi-Yu 1,3; Zhang, Chen 1,2; Dong, Wei 1,2; Dong, Fu-Bo1; Zhang, Jie 1,2; Chen, Xiao-Yan 1,2; Yao, Ren-Qi 4; Xiao, Zhong 1,2; Chen, Long-Wang 1,2; Yao, Yong-Ming 4; Lu, Zhong-Qiu1,2
发表日期	2023-08
发表期刊	Shock (Augusta, Ga.) 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Nicotinamide ribose NAD(+) SIRT1 sepsis T cells PD-1
其他关键词	SIRT1 ; ACTIVATION ; MORTALITY
摘要	T cell exhaustion is the main cause of sepsis-induced immunosuppression, and is associated with the poor prognosis. Nicotinamide adenine dinucleotide (NAD+) is well known for its anti-aging effect, but its role in sepsis-induced T cell exhaustion remains to be elucidated. In the present study, using a classic septic animal model, we found that the levels of NAD+ and its downstream molecule-sirtuins 1 (SIRT1) in T cells in sepsis were decreased. Supplementation with Nicotinamide ribose (NR), the precursor of NAD+, right after cecal ligation and puncture significantly increased the levels of NAD+ and SIRT1. Supplementation with NR alleviated the depletion of mononuclear cells and T lymphocytes in spleen in sepsis, and increased the levels of CD3+CD4+ and CD3+CD8+T cells. Interestingly, both Th1 and Th2 cells were expanded after NR treatment, but the balance of Th1/Th2 was partly restored. NR also inhibited the regulatory T cells expansion and PD-1 expression in CD4+T cells in sepsis. Additionally, the bacteria load, organ damage (lung, heart, liver and kidney) and the mortality of septic mice were reduced after NR supplementation. In summary, these results demonstrate the beneficial effect of NR on sepsis and T cell exhaustion, which is associated with NAD+/SIRT1 pathway.
资助项目	Key R&D Program Projects of Zhejiang Province[2021C03072];National Natural Science Foundation of China[81871583,82272201,82272202];Natural Science Foundation of Zhejiang Province[LQ22H150003];
出版者	LIPPINCOTT WILLIAMS & WILKINS
ISSN	1073-2322
EISSN	1540-0514
卷号	60 期号:2 页码:238-247
DOI	10.1097/SHK.0000000000002153
页数	10
WOS类目	Critical Care Medicine ; Hematology ; Surgery ; Peripheral Vascular Disease
WOS研究方向	General & Internal Medicine ; Hematology ; Surgery ; Cardiovascular System & Cardiology
WOS记录号	WOS:001052629100011
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37314209
SCOPUSEID	2-s2.0-85168427782
通讯作者地址	[Zhao, Guang-Ju]Emergency Department,The First Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Lu, Zhong-Qiu]Emergency Department,The First Hospital of Wenzhou Medical University,Nanbaixiang Street,Wenzhou,325000,China ; [Yao, Yong-Ming]Translational Medicine Research Center,Medical Innovation Research Division,Fourth Medical of the Chinese PLA General Hospital,Fucheng Road,Beijing,100048,China
Scopus学科分类	Emergency Medicine;Critical Care and Intensive Care Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181164
专题	附属第一医院附属第一医院_急诊科
通讯作者	Zhao, Guang-Ju; Yao, Yong-Ming; Lu, Zhong-Qiu
作者单位	1.Department of Emergency,The First Hospital of Wenzhou Medical University,Wenzhou Medical University,Wenzhou,China; 2.Wenzhou Key Laboratory of Emergency and Disaster Medicine,Wenzhou,China; 3.Department of Emergency,The First Affiliated Hospital of Ningbo University,Ningbo,China; 4.Translational Medicine Research Center,Medical Innovation Research Division,Fourth Medical of the Chinese PLA General Hospital,Beijing,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Zhao, Guang-Ju,Yang, Xi-Yu,Zhang, Chen,et al. Supplementation with Nicotinamide riboside attenuates T cell exhaustion and improves survival in sepsis[J]. Shock (Augusta, Ga.),2023,60(2):238-247.
APA	Zhao, Guang-Ju., Yang, Xi-Yu., Zhang, Chen., Dong, Wei., Dong, Fu-Bo., ... & Lu, Zhong-Qiu. (2023). Supplementation with Nicotinamide riboside attenuates T cell exhaustion and improves survival in sepsis. Shock (Augusta, Ga.), 60(2), 238-247.
MLA	Zhao, Guang-Ju,et al."Supplementation with Nicotinamide riboside attenuates T cell exhaustion and improves survival in sepsis".Shock (Augusta, Ga.) 60.2(2023):238-247.