A strontium/vancomycin composite coating on titanium implants for preventing bacterial infection and improving osseointegration

doi:10.1016/j.matdes.2023.112032

科研成果详情

题名	A strontium/vancomycin composite coating on titanium implants for preventing bacterial infection and improving osseointegration
作者	Shen, Yiguo 1; Wang, Kun 2; Wu, Weiliang 1; Feng, Wei 3; Chen, Jiansong 1; Gao, Qiang4
发表日期	2023-07
发表期刊	Materials and Design 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Bacteria Bioactivity Body fluids Composite coatings Deposition Hydrothermal synthesis Morphology Phosphate minerals Strontium Titanium dioxide Anti-infection Bacterial infections Bone tissue Clinical application Composites coating Implant failures Osseointegration Titania Titanium implants Vancomycin
其他关键词	ARTHROPLASTY ; OSTEOGENESIS ; SCAFFOLDS ; SURFACE
摘要	Postoperative bacterial infection and poor osseointegration with surrounding bone tissue are not only the critical causes of implant failure but also the major challenges in clinical application. Hereby, Titania (TiO2) microporous/nanofiber coating was firstly prepared on the surface of titanium (Ti) material by alkali-heat treatment process, and strontium (Sr)-doped coating (TS) was then prepared by hydrothermal synthesis. Finally, polydopamine-assisted co-deposition technology was utilized to deposit vancomycin (Van) onto TS surface (TSV), thus obtaining a medical composite coating with antibacterial property and improved osseointegration ability. According to antibacterial test, TSV has not only a 99.99% killing effect on methicillin-resistant Staphylococcus aureus (MRSA), but also a good anti-biofilm ability. The cell experiments showed that TSV could enhance the adhesion and proliferation of osteoblasts. Compared with pure Ti and TS, TSV induces the formation of bone apatite in simulated body fluid (SBF) test quickly, indicating that the coating has good biological activity. According to histopathological observation and bone morphology analysis, TSV showed highly effective infection prevention and excellent osteointegration in vivo. These test results suggested that it is feasible to prevent implant-associated infection and promote osseointegration by functionalization of the implant, so as to provide a fresh direction for clinical research. © 2023 The Author(s)
出版者	Elsevier Ltd
ISSN	0264-1275
EISSN	1873-4197
卷号	231
DOI	10.1016/j.matdes.2023.112032
页数	12
WOS类目	Materials Science, Multidisciplinary
WOS研究方向	Materials Science
WOS记录号	WOS:001060758200001
收录类别	EI ; SCIE ; SCOPUS
在线发表日期	2023-05
EI入藏号	20232214174281
EI主题词	Clinical research
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 482.2 Minerals ; 549.2 Alkaline Earth Metals ; 802.2 Chemical Reactions ; 802.3 Chemical Operations ; 804.2 Inorganic Compounds ; 813.2 Coating Materials ; 931.2 Physical Properties of Gases, Liquids and Solids ; 951 Materials Science
URL	查看原文
SCOPUSEID	2-s2.0-85160542742
通讯作者地址	[Chen, Jiansong]Department of Orthopedics,Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou,310052,China
Scopus学科分类	Materials Science (all);Mechanics of Materials;Mechanical Engineering
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181146
专题	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Chen, Jiansong
作者单位	1.Department of Orthopedics,Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou,310052,China; 2.Frontiers Science Center for Flexible Electronics (FSCFE),Xi'an Institute of Flexible Electronics (IFE) & Xi'an Institute of Biomedical Materials and Engineering (IBME),Northwestern Polytechnical University (NPU),Xi'an,710072,China; 3.Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM),Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM),Nanjing Tech University,Nanjing,211816,China; 4.School of Ophthalmology & Optometry,Eye Hospital,Wenzhou Medical University,Wenzhou,325027,China
推荐引用方式 GB/T 7714	Shen, Yiguo,Wang, Kun,Wu, Weiliang,et al. A strontium/vancomycin composite coating on titanium implants for preventing bacterial infection and improving osseointegration[J]. Materials and Design,2023,231.
APA	Shen, Yiguo, Wang, Kun, Wu, Weiliang, Feng, Wei, Chen, Jiansong, & Gao, Qiang. (2023). A strontium/vancomycin composite coating on titanium implants for preventing bacterial infection and improving osseointegration. Materials and Design, 231.
MLA	Shen, Yiguo,et al."A strontium/vancomycin composite coating on titanium implants for preventing bacterial infection and improving osseointegration".Materials and Design 231(2023).