From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases

doi:10.1007/s00011-023-01742-y

科研成果详情

题名	From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases
作者	Zhou, Xueyin 1; Gu, Yiming 1; Wang, Huihong 1; Zhou, Wei 1; Zou, Lei 1; Li, Shuting 1; Hua, Chunyan2; Gao, Sheng 3
发表日期	2023-06-14
发表期刊	INFLAMMATION RESEARCH 影响因子和分区
语种	英语
原始文献类型	Review ; Early Access
关键词	LAG3 Autoimmune disease Immune regulation Immune checkpoint Therapy
其他关键词	REGULATORY T-CELLS ; INFLAMMATORY-BOWEL-DISEASE ; LAG-3 CD223 ; MULTIPLE-SCLEROSIS ; DENDRITIC CELLS ; B-CELLS ; EXPRESSION ; PROTEIN ; TRANSCRIPTION ; ENGAGEMENT
摘要	BackgroundImmune checkpoints negatively regulate immune response, thereby playing an important role in maintaining immune homeostasis. Substantial studies have confirmed that blockade or deficiency of immune checkpoint pathways contributes to the deterioration of autoimmune diseases. In this context, focusing on immune checkpoints might provide alternative strategies for the treatment of autoimmunity. Lymphocyte activation gene 3 (LAG3), as a member of immune checkpoint, is critical in regulating immune responses as manifested in multiple preclinical studies and clinical trials. Recent success of dual-blockade of LAG3 and programmed death-1 in melanoma also supports the notion that LAG3 is a crucial regulator in immune tolerance.MethodsWe wrote this review article by searching the PubMed, Web of Science and Google Scholar databases.ConclusionIn this review, we summarize the molecular structure and the action mechanisms of LAG3. Additionally, we highlight its roles in diverse autoimmune diseases and discuss how the manipulation of the LAG3 pathway can serve as a promising therapeutic strategy as well as its specific mechanism with the aim of filling the gaps from bench to bedside.
资助项目	National Natural Science Foundation of China[81901660];China Scholarship Council[201808330646]
出版者	SPRINGER BASEL AG
ISSN	1023-3830
EISSN	1420-908X
卷号	72 期号:6 页码:1215-1235
DOI	10.1007/s00011-023-01742-y
页数	21
WOS类目	Cell Biology ; Immunology
WOS研究方向	Cell Biology ; Immunology
WOS记录号	WOS:001007623000001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-06
URL	查看原文
PubMed ID	37314518
SCOPUSEID	2-s2.0-85161831558
通讯作者地址	[Hua, Chunyan]School of Basic Medical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China ; [Gao, Sheng]Laboratory Animal Center,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
Scopus学科分类	Immunology;Pharmacology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181121
专题	温州医科大学基础医学院（机能实验教学中心）实验动物中心
通讯作者	Hua, Chunyan; Gao, Sheng
作者单位	1.School of the 2nd Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China; 2.School of Basic Medical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 3.Laboratory Animal Center,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
第一作者单位	温州医科大学
通讯作者单位	基础医学院（机能实验教学中心）; 实验动物中心
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Zhou, Xueyin,Gu, Yiming,Wang, Huihong,et al. From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases[J]. INFLAMMATION RESEARCH,2023,72(6):1215-1235.
APA	Zhou, Xueyin., Gu, Yiming., Wang, Huihong., Zhou, Wei., Zou, Lei., ... & Gao, Sheng. (2023). From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases. INFLAMMATION RESEARCH, 72(6), 1215-1235.
MLA	Zhou, Xueyin,et al."From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases".INFLAMMATION RESEARCH 72.6(2023):1215-1235.