Triptolide attenuates irritable bowel syndrome via inhibiting ODC1

doi:10.1186/s12876-023-02847-8

科研成果详情

题名	Triptolide attenuates irritable bowel syndrome via inhibiting ODC1
作者	Zhu, Ning1; Zhu, Liuyan2; Zhang, Xueliang 2; Huang, Chengbin 3; Xiang, Wenjun 4; Huang, Bingwu5
发表日期	2023-06-12
发表期刊	BMC GASTROENTEROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Triptolide Irritable bowel syndrome Inflammation Ornithine decarboxylase 1
其他关键词	RAT MODEL ; INFLAMMATION ; STRESS ; METABOLISM ; MANAGEMENT ; CANCER ; AXIS
摘要	BackgroundIrritable bowel syndrome (IBS) is a chronic disorder of the gut-brain axis with significant morbidity. Triptolide, an active compound extracted from Tripterygium wilfordii Hook F (TwHF), has been widely used as a major medicinal herb in the treatment of inflammatory disease.MethodsThe chronic-acute combined stress (CAS) stimulation was used to establish IBS rat model. The model rats were then gavaged with triptolide. Forced swimming, marble-burying, fecal weight and abdominal withdrawal reflex (AWR) score were recorded. Pathologic changes in the ileal and colonic tissues were validated by hematoxylin and eosin staining. The inflammatory cytokines and Ornithine Decarboxylase-1 (ODC1) in the ileal and colonic tissues were performed by ELISA and WB.ResultsTriptolide didn't have antidepressant- and antianxiety- effects in rats caused by CAS, but decreased fecal weight and AWR score. In addition, Triptolide reduced the release of IL-1, IL-6, and TNF-alpha and the expression of ODC1 in the ileum and colon.ConclusionThe therapeutic efficacy of triptolide for IBS induced by CAS was revealed in this study, which may be related to the reduction of ODC1.
出版者	BMC
ISSN	1471-230X
EISSN	1471-230X
卷号	23 期号:1
DOI	10.1186/s12876-023-02847-8
页数	8
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:001003637400001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37308808
SCOPUSEID	2-s2.0-85161892974
通讯作者地址	[Zhu, Ning]Department of Cardiology,The Third Affiliated Hospital of Shanghai University (Wenzhou People’s Hospital),The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University,No. 299 Guan Road, Zhejiang Province,Wenzhou,325000,China ; [Huang, Bingwu]Department of Anesthesiology and Perioperative Medicine,The Second Affiliated Hospital,Yuying Children’s Hospital of Wenzhou Medical University,109 Xueyuan West Road, Zhejiang Province,Wenzhou,325000,China
Scopus学科分类	Gastroenterology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181090
专题	其他_温州市第三临床学院（温州市人民医院）附属第二医院附属第一医院_麻醉科
通讯作者	Zhu, Ning; Huang, Bingwu
作者单位	1.Department of Cardiology,The Third Affiliated Hospital of Shanghai University (Wenzhou People’s Hospital),The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University,No. 299 Guan Road, Zhejiang Province,Wenzhou,325000,China; 2.Department of General Practice,The Third Affiliated Hospital of Shanghai University (Wenzhou People’s Hospital),The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University,No. 299 Guan Road, Zhejiang Province,Wenzhou,325000,China; 3.Department of Orthopedic Surgery,The Second Affiliated Hospital,Yuying Children’s Hospital of Wenzhou Medical University,109 Xueyuan West Road, Zhejiang Province,Wenzhou,325000,China; 4.Department of Pathology,The Third Affiliated Hospital of Shanghai University (Wenzhou People’s Hospital),The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University,No. 299 Guan Road, Zhejiang Province,Wenzhou,325000,China; 5.Department of Anesthesiology and Perioperative Medicine,The Second Affiliated Hospital,Yuying Children’s Hospital of Wenzhou Medical University,109 Xueyuan West Road, Zhejiang Province,Wenzhou,325000,China
第一作者单位	其他_温州市第三临床学院（温州市人民医院）
通讯作者单位	其他_温州市第三临床学院（温州市人民医院）; 附属第一医院_麻醉科
第一作者的第一单位	其他_温州市第三临床学院（温州市人民医院）
推荐引用方式 GB/T 7714	Zhu, Ning,Zhu, Liuyan,Zhang, Xueliang,et al. Triptolide attenuates irritable bowel syndrome via inhibiting ODC1[J]. BMC GASTROENTEROLOGY,2023,23(1).
APA	Zhu, Ning, Zhu, Liuyan, Zhang, Xueliang, Huang, Chengbin, Xiang, Wenjun, & Huang, Bingwu. (2023). Triptolide attenuates irritable bowel syndrome via inhibiting ODC1. BMC GASTROENTEROLOGY, 23(1).
MLA	Zhu, Ning,et al."Triptolide attenuates irritable bowel syndrome via inhibiting ODC1".BMC GASTROENTEROLOGY 23.1(2023).