FAK inhibitor PF-562271 inhibits the migration and proliferation of high-grade serous ovarian cancer cells through FAK and FAK mediated cell cycle arrest

doi:10.1007/s12032-023-02092-9

科研成果详情

题名	FAK inhibitor PF-562271 inhibits the migration and proliferation of high-grade serous ovarian cancer cells through FAK and FAK mediated cell cycle arrest
作者	Pan, Qionghui 1; Wang, Qingyu 2; Zhao, Tianshu 2; Zhao, Xinyu 2; Liang, Yixin 2; Shi, Mengyun2; Chen, Cong 1; Lin, Feng 2
发表日期	2023-06-29
发表期刊	MEDICAL ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	PF-562271 Ovarian cancer Proliferation Migration Cell cycle arrest
其他关键词	FOCAL ADHESION KINASE ; PHASE-I ; DIAGNOSIS ; MDM2
摘要	Focal adhesion kinase (FAK) is a promising therapeutic target for various cancers and its inhibitor development is in full swing. PF-562271 is a classic FAK inhibitor that has shown promising preclinical data and has been found to exhibit an anti-migration effect on some cancer cells. However, its anticancer effect on high-grade serous ovarian cancer (HGSOC) has not been reported. In this study, we evaluated the anti-migration and anti-proliferation effects of PF-562271 against HGSOC SKOV3 and A2780 cells, as well as the underlying mechanism. The results demonstrated that FAK was overexpressed in clinical HGSOC tissues and was positively correlated with the pathological progression of HGSOC. Moreover, HGSOC patients with high FAK expression levels exhibited low survival rates. PF-562271 treatment significantly inhibited the cell adhesion and migration of SKOV3 and A2780 cells by inhibiting p-FAK expression and decreasing the FA surface area. Additionally, PF-562271 treatment inhibited colony formation and induced cell senescence through G1 phase cell cycle arrest mediated DNA replication inhibition. Taken together, the findings demonstrated that FAK inhibitor PF-562271 significantly inhibits HGSOC cell adhesion, migration, and proliferation process through FAK and/or FAK mediated cell cycle arrest, and suggested that PF-562271 could serve as a potential oncotherapeutic agent for HGSOC targeting treatment.
资助项目	Wenzhou Basic Medical and Health Technology Project[Y20210325];Wenzhou Basic Medical and Health Technology Project[Y20210024]
出版者	HUMANA PRESS INC
ISSN	1357-0560
EISSN	1559-131X
卷号	40 期号:8
DOI	10.1007/s12032-023-02092-9
页数	12
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001018530900001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37382687
SCOPUSEID	2-s2.0-85163749316
通讯作者地址	[Lin, Feng]Department of Gynecology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
Scopus学科分类	Hematology;Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181087
专题	其他_附属第三医院（瑞安市人民医院）附属第一医院
通讯作者	Lin, Feng
作者单位	1.Third Affiliated Hospital of Shanghai University,Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University,Wenzhou People’s Hospital,Wenzhou,China; 2.Department of Gynecology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
第一作者单位	其他_附属第三医院（瑞安市人民医院）
通讯作者单位	附属第一医院
第一作者的第一单位	其他_附属第三医院（瑞安市人民医院）
推荐引用方式 GB/T 7714	Pan, Qionghui,Wang, Qingyu,Zhao, Tianshu,et al. FAK inhibitor PF-562271 inhibits the migration and proliferation of high-grade serous ovarian cancer cells through FAK and FAK mediated cell cycle arrest[J]. MEDICAL ONCOLOGY,2023,40(8).
APA	Pan, Qionghui., Wang, Qingyu., Zhao, Tianshu., Zhao, Xinyu., Liang, Yixin., ... & Lin, Feng. (2023). FAK inhibitor PF-562271 inhibits the migration and proliferation of high-grade serous ovarian cancer cells through FAK and FAK mediated cell cycle arrest. MEDICAL ONCOLOGY, 40(8).
MLA	Pan, Qionghui,et al."FAK inhibitor PF-562271 inhibits the migration and proliferation of high-grade serous ovarian cancer cells through FAK and FAK mediated cell cycle arrest".MEDICAL ONCOLOGY 40.8(2023).