Upregulation of FAM50A promotes cancer development

doi:10.1007/s12032-023-02072-z

科研成果详情

题名	Upregulation of FAM50A promotes cancer development
作者	Hu, Mei-Zhen 1; Dai, Zhi-Zheng 1; Ji, Hong-Yu 1; Zheng, An-Qi 2; Liang, Hang 3; Shen, Mei-Mei 4; Liu, Jun-Nan 3; Tang, Kai-Fu 1; Zhu, Shu-Juan 3; Wang, Ke-Jian 3
发表日期	2023-07-01
发表期刊	MEDICAL ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	FAM50A Prognosis Immune cell infiltration DNA damage Cell proliferation Cell migration and invasion
其他关键词	DNA-DAMAGE ; GENOME ; CELLS ; EXPRESSION ; REPAIR
摘要	FAM50A encodes a nuclear protein involved in mRNA processing; however, its role in cancer development remains unclear. Herein, we conducted an integrative pan-cancer analysis using The Cancer Genome Atlas, Genotype-Tissue Expression, and the Clinical Proteomic Tumor Analysis Consortium databases. Based on the gene expression data from TCGA and GTEx databases, we compared FAM50A mRNA levels in 33 types of human cancer tissues to those in corresponding normal tissues and found that FAM50A mRNA level was upregulated in 20 of the 33 types of common cancer tissues. Then, we compared the DNA methylation status of the FAM50A promoter in tumor tissues to that in corresponding normal tissues. FAM50A upregulation was accompanied by promoter hypomethylation in 8 of the 20 types of tumor tissues, suggesting that promoter hypomethylation contributes to the upregulation of FAM50A in these cancer tissues. Elevated FAM50A expression in 10 types of cancer tissues was associated with poor prognosis in patients with cancer. FAM50A expression was positively correlated with CD4+ T-lymphocyte and dendritic cell infiltration in cancer tissues but was negatively correlated with CD8+ T-cell infiltration in cancer tissues. FAM50A knockdown caused DNA damage, induced interferon beta and interleukin-6 expression, and repressed the proliferation, invasion, and migration of cancer cells. Our findings indicate that FAM50A might be useful in cancer detection, reveal insights into its role in cancer development, and may contribute to the development of cancer diagnostics and treatments.
资助项目	National Natural Science Foundation of China[81972648];National Natural Science Foundation of China[82172915];National Natural Science Foundation of China[81773011];Chongqing Medical University Program for Youth Innovation in Future Medicine[W0084]
出版者	HUMANA PRESS INC
ISSN	1357-0560
EISSN	1559-131X
卷号	40 期号:8
DOI	10.1007/s12032-023-02072-z
页数	15
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001018495300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37393403
SCOPUSEID	2-s2.0-85164128557
通讯作者地址	[Zhu, Shu-Juan]School of Basic Medicine,Chongqing Medical University,Chongqing,400016,China ; [Wang, Ke-Jian]School of Basic Medicine,Chongqing Medical University,Chongqing,400016,China
Scopus学科分类	Hematology;Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181068
专题	附属第一医院
通讯作者	Zhu, Shu-Juan; Wang, Ke-Jian
作者单位	1.Key Laboratory of Molecular Biology for Infectious Diseases,Ministry of Education,Chongqing Medical University,Chongqing,400016,China; 2.The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,325015,China; 3.School of Basic Medicine,Chongqing Medical University,Chongqing,400016,China; 4.Department of Gastroenterology,The Second Affiliated Hospital of Chongqing Medical University,Choqing,400016,China
推荐引用方式 GB/T 7714	Hu, Mei-Zhen,Dai, Zhi-Zheng,Ji, Hong-Yu,et al. Upregulation of FAM50A promotes cancer development[J]. MEDICAL ONCOLOGY,2023,40(8).
APA	Hu, Mei-Zhen., Dai, Zhi-Zheng., Ji, Hong-Yu., Zheng, An-Qi., Liang, Hang., ... & Wang, Ke-Jian. (2023). Upregulation of FAM50A promotes cancer development. MEDICAL ONCOLOGY, 40(8).
MLA	Hu, Mei-Zhen,et al."Upregulation of FAM50A promotes cancer development".MEDICAL ONCOLOGY 40.8(2023).