Association of retinal microvascular abnormalities and neuromyelitis optica spectrum disorders with optical coherence tomography angiography

doi:10.3389/fnins.2023.1194661

科研成果详情

题名	Association of retinal microvascular abnormalities and neuromyelitis optica spectrum disorders with optical coherence tomography angiography
作者	Guo, Jiaqi 1,2; Zhang, Dan 3; Gong, Yan 4; Liu, Jiang 5; Zhang, Jiong1,4; Zhao, Yitian 1,4
发表日期	2023-06-09
发表期刊	FRONTIERS IN NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	OCTA retinal microvascular neuromyelitis optica spectrum disorders deep learning segmentation
其他关键词	NERVE-FIBER LAYER ; MULTIPLE-SCLEROSIS ; NMO-IGG ; AQUAPORIN-4 ; THICKNESS ; ASTROCYTE
摘要	IntroductionNeuromyelitis optica spectrum disorders (NMOSD) are autoimmune central nervous system diseases characterized by the immune system's abnormal attack on glial cells and neurons. Optic neuritis (ON) is one of the indicators of NMOSD, often starting unilaterally and potentially affecting both eyes later in the disease progression, leading to visual impairment. Optical coherence tomography angiography (OCTA) has the potential to aid in the early diagnosis of NMOSD by examining ophthalmic imaging and may offer a window for disease prevention. MethodsIn this study, we collected OCTA images from 22 NMOSD patients (44 images) and 25 healthy individuals (50 images) to investigate retinal microvascular changes in NMOSD. We employed effective retinal microvascular segmentation and foveal avascular zone (FAZ) segmentation techniques to extract key OCTA structures for biomarker analysis. A total of 12 microvascular features were extracted using specifically designed methods based on the segmentation results. The OCTA images of NMOSD patients were classified into two groups: optic neuritis (ON) and non-optic neuritis (non-ON). Each group was compared separately with a healthy control (HC) group. ResultsStatistical analysis revealed that the non-ON group displayed shape changes in the deep layer of the retina, specifically in the FAZ. However, there were no significant microvascular differences between the non-ON group and the HC group. In contrast, the ON group exhibited microvascular degeneration in both superficial and deep retinal layers. Sub-regional analysis revealed that pathological variations predominantly occurred on the side affected by ON, particularly within the internal ring near the FAZ. DiscussionThe findings of this study highlight the potential of OCTA in evaluating retinal microvascular changes associated with NMOSD. The shape alterations observed in the FAZ of the non-ON group suggest localized vascular abnormalities. In the ON group, microvascular degeneration in both superficial and deep retinal layers indicates more extensive vascular damage. Sub-regional analysis further emphasizes the impact of optic neuritis on pathological variations, particularly near the FAZ's internal ring. ConclusionThis study provides insights into the retinal microvascular changes associated with NMOSD using OCTA imaging. The identified biomarkers and observed alterations may contribute to the early diagnosis and monitoring of NMOSD, potentially offering a time window for intervention and prevention of disease progression.
资助项目	Ningbo Natural Science Foundation[20221JCGY010608,2022J143];Zhejiang Provincial Natural Science Foundation[LQ23F010002,LR22F020008,LZ19F010001];Youth Innovation Promotion Association CAS[2021298];Zhejiang Provincial Department of Education[Y202250360];Ningbo University of Technology[2019B10033,2019B10061,2021Z054,2022KQ29];
出版者	FRONTIERS MEDIA SA
ISSN	1662-453X
EISSN	1662-453X
卷号	17
DOI	10.3389/fnins.2023.1194661
页数	13
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:001016196300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37360155
SCOPUSEID	2-s2.0-85163615540
通讯作者地址	[Zhang, Jiong]Cixi Institute of Biomedical Engineering,Ningbo Institute of Materials Technology and Engineering,Chinese Academy of Sciences,Ningbo,China ; [Zhao, Yitian]Cixi Institute of Biomedical Engineering,Ningbo Institute of Materials Technology and Engineering,Chinese Academy of Sciences,Ningbo,China
Scopus学科分类	Neuroscience (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/181024
专题	其他_附属宁波市眼科医院
通讯作者	Zhang, Jiong; Zhao, Yitian
作者单位	1.Cixi Institute of Biomedical Engineering,Ningbo Institute of Materials Technology and Engineering,Chinese Academy of Sciences,Ningbo,China; 2.University of Chinese Academy of Sciences,Beijing,China; 3.School of Cyber Science and Engineering,Ningbo University of Technology,Ningbo,China; 4.The Affiliated Ningbo Eye Hospital of Wenzhou Medical University,Ningbo,China; 5.Department of Computer Science and Engineering,Southern University of Science and Technology,Shenzhen,China
推荐引用方式 GB/T 7714	Guo, Jiaqi,Zhang, Dan,Gong, Yan,et al. Association of retinal microvascular abnormalities and neuromyelitis optica spectrum disorders with optical coherence tomography angiography[J]. FRONTIERS IN NEUROSCIENCE,2023,17.
APA	Guo, Jiaqi, Zhang, Dan, Gong, Yan, Liu, Jiang, Zhang, Jiong, & Zhao, Yitian. (2023). Association of retinal microvascular abnormalities and neuromyelitis optica spectrum disorders with optical coherence tomography angiography. FRONTIERS IN NEUROSCIENCE, 17.
MLA	Guo, Jiaqi,et al."Association of retinal microvascular abnormalities and neuromyelitis optica spectrum disorders with optical coherence tomography angiography".FRONTIERS IN NEUROSCIENCE 17(2023).