Maternal high fat diet multigenerationally programs HPA function and behaviors in male rat offspring

doi:10.1210/endocr/bqad090

科研成果详情

题名	Maternal high fat diet multigenerationally programs HPA function and behaviors in male rat offspring
作者	Lin, Cheng Cheng 1; Lei, Qiang2; Yu, Meng Na 2; Lin, Yu Hang 2; Lu, Hui Zhen 2; Huang, Yang Ping 2; Wang, Hong2; Xu, HuiQin2; Lin, YuanShao2
发表日期	2023-06-06
发表期刊	Endocrinology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	HPA axis behavior calcitonin gene-related peptide generation high fat diet maternal
其他关键词	GENE-RELATED PEPTIDE ; PITUITARY-ADRENAL AXIS ; GESTATIONAL ENVIRONMENT ; PRENATAL STRESS ; MILD STRESS ; FOOD-INTAKE ; DEPRESSION ; RESPONSES ; NEUROENDOCRINE ; HYPERTENSION
摘要	Maternal environmental factors have been demonstrated to exert significant influences on the health of offspring. The hypothalamic-pituitary-adrenal (HPA) axis is an important neuroendocrine stress system that can be influenced by early-life challenges. Our previous research has revealed that the consumption of a high-fat diet (HFD) by pregnant and lactating rats leads to the programming of HPA axis activity in male offspring of the first generation (referred to as F1HFD/C). The present study aimed to investigate whether the observed remodeling of the HPA axis could be inherited by second-generation male offspring (referred to as F2HFD/C), following maternal HFD exposure. The results showed that F2HFD/C rats exhibited enhanced basal HPA axis activity, similar to their F1HFD/C ancestors. Moreover, F2HFD/C rats displayed exacerbated corticosterone responses to restraint and lipopolysaccharide-induced stress, but not to insulin-induced hypoglycemia stress. Furthermore, maternal HFD exposure significantly aggravated depression-like behavior in the F2 generation subjected to chronic unpredictable mild stress. To investigate the role of central CGRP signaling in maternal diet-induced programming of the HPA axis across generations, we conducted central infusion of αCGRP8-37, a CGRP receptor antagonist, in F2HFD/C rats. The results demonstrated that αCGRP8-37, attenuated depression-like behaviors and reduced the hyperresponsiveness of the HPA axis to restraint stress in these rats. Therefore, central CGRP signaling may contribute to maternal diet-induced programming of HPA axis across generations. In conclusion, our study provides evidence that maternal HFD consumption can lead to multigenerational programming of the HPA axis and behaviors in adult male descendants.
资助项目	Foundation of Wenzhou Science and Technology Bureau[Y2020243];National Natural Science Foundation of China[32271071,81673144];
出版者	ENDOCRINE SOC
ISSN	0013-7227
EISSN	1945-7170
卷号	164 期号:7
DOI	10.1210/endocr/bqad090
页数	14
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001016338400003
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37289029
SCOPUSEID	2-s2.0-85163921666
通讯作者地址	[Lin, YuanShao]Department of Neurology,First Affiliated Hospital of Wenzhou Medical University,OuHai District,Wenzhou,325000,China
Scopus学科分类	Endocrinology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180685
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	Lin, YuanShao
作者单位	1.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Neurology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Lin, Cheng Cheng,Lei, Qiang,Yu, Meng Na,et al. Maternal high fat diet multigenerationally programs HPA function and behaviors in male rat offspring[J]. Endocrinology,2023,164(7).
APA	Lin, Cheng Cheng., Lei, Qiang., Yu, Meng Na., Lin, Yu Hang., Lu, Hui Zhen., ... & Lin, YuanShao. (2023). Maternal high fat diet multigenerationally programs HPA function and behaviors in male rat offspring. Endocrinology, 164(7).
MLA	Lin, Cheng Cheng,et al."Maternal high fat diet multigenerationally programs HPA function and behaviors in male rat offspring".Endocrinology 164.7(2023).