科研成果详情

题名Changes in serum uric acid, serum uric acid/serum creatinine ratio, and gamma-glutamyltransferase might predict the efficacy of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer
作者
发表日期2023-06-07
发表期刊Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]   影响因子和分区
语种英语
原始文献类型Journal Article
关键词Biomarkers Changes Efficacy Neoadjuvant radiotherapy Treatment
其他关键词PREOPERATIVE RADIOTHERAPY ; POSTOPERATIVE CHEMORADIOTHERAPY ; LYMPHOVASCULAR INVASION ; CLINICAL MANAGEMENT ; PROGNOSTIC-FACTORS ; EUROPEAN-SOCIETY ; TUMOR RESPONSE ; RISK ; CHEMOTHERAPY ; MORTALITY
摘要The purpose of this study was to investigate the predictive value of changes in serum uric acid (SUA), the ratio of serum uric acid to serum creatinine (SUA/SCr), and serum gamma-glutamyltransferase (GGT) from before to after therapy in patients with locally advanced rectal cancer (LARC)., Data from 114 LARC patients from January 2016 to December 2021 were included in this retrospective study. All patients received neoadjuvant chemoradiotherapy (nCRT) and total mesorectal excision (TME). The change in SUA was calculated as a ratio: (SUA level after nCRT-SUA level before nCRT)/SUA level before nCRT. The change ratios of SUA/SCr and GGT were calculated in the same way. The efficacy of nCRT was evaluated by magnetic resonance (MR) and postoperative pathological response. A nonlinear model was used to evaluate whether the change ratios of SUA, SUA/SCr, and GGT were associated with the efficacy of nCRT. The predictive power of the change ratios of SUA, SUA/SCr, and GGT was assessed by receiver operating characteristic (ROC) curves. Univariate and multivariate Cox regression analyses were employed to measure the associations between disease-free survival (DFS) and other predictive indicators. The Kaplan-Meier method was used to further compare DFS between groups., The nonlinear model indicated that the change ratios of SUA, SUA/SCr, and GGT were associated with the efficacy of nCRT. The change ratios of SUA, SUA/SCr, and GGT were used to predict the area under the ROC curve of efficacy for nCRT (0.95, 0.91-0.99), which was better than the prediction by the change ratio of SUA (0.94, 0.89-0.99), SUA/SCr (0.90, 0.84-0.96), or GGT alone (0.86, 0.79-0.93; p < 0.05). The optimal cut-off values of SUA, SUA/SCr, and GGT change were 0.02, 0.01, and 0.04, respectively. The Kaplan-Meier method indicated that patients with SUA, SUA/SCr, or GGT changes greater than the cut-off values had shorter DFS (p < 0.05)., Change ratios of SUA, SUA/SCr, or GGT greater than the cut-off values implied a risk of poor pathological response after nCRT and shorter DFS in LARC patients.
资助项目Basic Scientific Research Operating Expenses of Wenzhou Medical University [KYYW201923]
出版者SPRINGER HEIDELBERG
ISSN0179-7158
EISSN1439-099X
卷号200期号:6页码:523-534
DOI10.1007/s00066-023-02096-4
页数12
WOS类目Oncology ; Radiology, Nuclear Medicine & Medical Imaging
WOS研究方向Oncology ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:001002907800003
收录类别PUBMED ; SCIE ; SCOPUS
在线发表日期2023-06
URL查看原文
PubMed ID37286741
SCOPUSEID2-s2.0-85161266633
通讯作者地址[Zou, Changlin]Department of Radiotherapy,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Xie, Raoying]Department of Radiotherapy,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类Radiology, Nuclear Medicine and Imaging;Oncology
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/180677
专题附属第一医院_放化疗科
通讯作者Zou, Changlin; Xie, Raoying
作者单位
Department of Radiotherapy,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
通讯作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
第一作者的第一单位附属第一医院
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Shao, Zhenyong,Xu, Yuyan,Zhang, Xuebang,et al. Changes in serum uric acid, serum uric acid/serum creatinine ratio, and gamma-glutamyltransferase might predict the efficacy of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer[J]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al],2023,200(6):523-534.
APA Shao, Zhenyong, Xu, Yuyan, Zhang, Xuebang, Zou, Changlin, & Xie, Raoying. (2023). Changes in serum uric acid, serum uric acid/serum creatinine ratio, and gamma-glutamyltransferase might predict the efficacy of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 200(6), 523-534.
MLA Shao, Zhenyong,et al."Changes in serum uric acid, serum uric acid/serum creatinine ratio, and gamma-glutamyltransferase might predict the efficacy of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer".Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 200.6(2023):523-534.

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