Association between serum progesterone levels on the day of frozen-thawed embryo transfer and pregnancy outcomes after artificial endometrial preparation

doi:10.1186/s12884-023-05596-4

科研成果详情

题名	Association between serum progesterone levels on the day of frozen-thawed embryo transfer and pregnancy outcomes after artificial endometrial preparation
作者	Zhu, Qianqian 1; Huang, Jialyu 2; Lin, Yue3; Jiang, Liyao 4; Huang, Xuefeng3; Zhu, Jing 3
发表日期	2023-05-30
发表期刊	BMC pregnancy and childbirth 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Artificial cycle Dydrogesterone Frozen embryo transfer Live birth rate Progesterone
其他关键词	LUTEAL-PHASE SUPPORT ; RANDOMIZED CONTROLLED-TRIAL ; VAGINAL PROGESTERONE ; ORAL DYDROGESTERONE ; TRANSFER CYCLES ; LIVE BIRTH ; IVF ; FRESH ; SUPPLEMENTATION ; REPLACEMENT
摘要	Previous studies have examined that a range of optimal serum P level during the implantation period was associated with optimal live birth rates. However, those results obtained with vaginal or intramuscular route of progesterone administration for luteal phase support (LPS) alone. Is there a relationship between the serum progesterone (P) on the day of frozen-thawed embryo transfer (FET) with the likelihood of a live birth (LB) in artificial cycles (AC) when using a combination of oral dydrogesterone and vaginal progesterone for LPS?, {AbstractText=This was a retrospective study of 3659 FET cycles with artificial endometrial preparation in a Chinese tertiary-care academic medical centre from January 2015 to February 2017. Endometrial preparation was performed using estradiol (E2) valerate (Fematon-red tablets) 8 mg/d beginning on day 3 of the cycle, followed by administration of P both orally (8 mg/d Fematon-yellow tablets) and vaginally (400 mg/d; Utrogestan). The primary endpoint was live birth rate (LBR). The association between the serum P level on the embryo transfer day and pregnancy outcomes was evaluated by univariable and multivariable logistic regression analysis.}, The LBRs according to the serum P quartiles were as follows: Q1: 35.7%; Q2: 37.4%; Q3: 39.1% and Q4: 38.9%. Logistic regression analysis showed that the odds of a LB were not significantly different between the low (P < 7.9 ng/mL) and high (P ≥ 7.9 ng/mL) progesterone groups before or after adjustment (crude OR = 0.89, 95% CI: 0.76-1.04; adjusted OR = 0.89, 95% CI: 0.75-1.04)., The present study suggests that the serum P levels on the day of embryo transfer (ET) do not correlate with the likelihood of a LB in artificial cycles when using a combination of oral dydrogesterone and vaginal progesterone for luteal phase support.
资助项目	National Nature Science Foundation of China[81903324];
出版者	BMC
ISSN	1471-2393
EISSN	1471-2393
卷号	23 期号:1
DOI	10.1186/s12884-023-05596-4
页数	9
WOS类目	Obstetrics & Gynecology
WOS研究方向	Obstetrics & Gynecology
WOS记录号	WOS:000998578100004
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37254095
SCOPUSEID	2-s2.0-85160602140
通讯作者地址	[Huang, Xuefeng]Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Zhu, Jing]Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Obstetrics and Gynecology
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180609
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心附属第一医院附属第一医院_生殖医学中心
通讯作者	Huang, Xuefeng; Zhu, Jing
作者单位	1.Department of Assisted Reproduction,Shanghai Ninth People’s Hospital,Shanghai Jiaotong University School of Medicine,Shanghai,China; 2.Center for Reproductive Medicine,Jiangxi Maternal and Child Health Hospital,Nanchang University School of Medicine,Nanchang,China; 3.Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Department of Obstetrics and Gynecology,Wenzhou Lucheng People’s Hospital,Wenzhou,China
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 生殖医学中心
推荐引用方式 GB/T 7714	Zhu, Qianqian,Huang, Jialyu,Lin, Yue,et al. Association between serum progesterone levels on the day of frozen-thawed embryo transfer and pregnancy outcomes after artificial endometrial preparation[J]. BMC pregnancy and childbirth,2023,23(1).
APA	Zhu, Qianqian, Huang, Jialyu, Lin, Yue, Jiang, Liyao, Huang, Xuefeng, & Zhu, Jing. (2023). Association between serum progesterone levels on the day of frozen-thawed embryo transfer and pregnancy outcomes after artificial endometrial preparation. BMC pregnancy and childbirth, 23(1).
MLA	Zhu, Qianqian,et al."Association between serum progesterone levels on the day of frozen-thawed embryo transfer and pregnancy outcomes after artificial endometrial preparation".BMC pregnancy and childbirth 23.1(2023).