TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC

doi:10.1186/s12575-023-00199-x

科研成果详情

题名	TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC
作者	Tang, Bufu 1,2; Wang, Yajie 1,3; Zhu, Jinyu 1,4; Song, Jingjing 1,3; Fang, Shiji1,3; Weng, Qiaoyou 1,3; Yang, Yang 1,3; Tu, Jianfei1,3; Zhao, Zhongwei1,3; Chen, Minjiang1,3; Xu, Min1,3; Chen, Weiqian1,3; Ji, Jiansong 1,3
发表日期	2023-05-19
发表期刊	BIOLOGICAL PROCEDURES ONLINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Hepatocellular carcinoma (HCC) Transarterial chemoembolization (TACE) NDRG1 Prognosis Immunotherapy
其他关键词	HEPATOCELLULAR-CARCINOMA ; CANCER ; SURVIVAL ; THERAPY ; SYSTEM ; GENES ; CELL
摘要	BackgroundThe treatment efficacy of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) varies widely between individuals. The aim of this study was to identify subtype landscapes and responser related to TACE, and further clarify the regulatory effect and corresponding mechanism of NDRG1 on HCC tumorgenesis and metastasis.MethodsThe principal component analysis (PCA) algorithm was used to construct a TACE response scoring (TRscore) system. The random forest algorithm was applied to identify the TACE response-related core gene NDRG1 of HCC, and its role in the prognosis of HCC was explored. The role of NDRG1 in the progression and metastasis of HCC and functional mechanism were confirmed using several experimental methods.ResultsBased on the GSE14520 and GSE104580 cohorts, we identified 2 TACE response-related molecular subtypes for HCC with significant differences in clinical features, and the TACE prognosis of Cluster A was significantly better than that of Cluster B (p < 0.0001). We then established the TRscore system and found that the low TRscore group showed a higher probability of survival and a lower rate of recurrence than the high TRscore group (p < 0.05) in both the HCC and TACE-treated HCC cohorts within the GSE14520 cohort. NDRG1 was determined to be the the hub gene associated with the TACE response of HCC and its high expression suggested a poor prognosis. Furthermore, The suppression of NDRG1 konckdown in tumorgenesis and metastasis of HCC was clarified in both vivo and vitro, which was importantly achieved through inducing ferroptosis in HCC cells, especially contributing to RLS3-induced ferroptosis.ConclusionThe constructed TACE response-related molecular subtypes and TRscores can specifically and accurately predict TACE prognosis for HCC. In addition, the TACE response-related hub gene NDRG1 may act as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC, which laid a new foundation for the development of new potential targeted therapy strategies to improve disease prognosis in HCC patients.
资助项目	Key R&D program of Zhejiang Province[2020ZJZC03];Medical health Project of Zhejiang Province[2020KY380];National Key Research and Development projects intergovernmental cooperation in science and technology of China[2018YFE0126900];National Natural Science Foundation of China[81901848,82072025];Natural Science Foundation of Zhejiang Province[LY21H160010];
出版者	BMC
ISSN	1480-9222
EISSN	1480-9222
卷号	25 期号:1
DOI	10.1186/s12575-023-00199-x
页数	22
WOS类目	Biochemical Research Methods
WOS研究方向	Biochemistry & Molecular Biology
WOS记录号	WOS:000991013000001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37208604
SCOPUSEID	2-s2.0-85160050622
通讯作者地址	[Chen, Weiqian]Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research,Lishui Hospital,School of Medicine,Zhejiang University,Lishui,323000,China ; [Ji, Jiansong]Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research,Lishui Hospital,School of Medicine,Zhejiang University,Lishui,323000,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180150
专题	其他_附属第五医院（丽水市中心医院）
通讯作者	Chen, Weiqian; Ji, Jiansong
作者单位	1.Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research,Lishui Hospital,School of Medicine,Zhejiang University,Lishui,323000,China; 2.Department of Radiation Oncology,Key Laboratory of Cancer Prevention and Intervention,The Second Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,310058,China; 3.Department of Radiology,the Fifth Affiliated Hospital of Wenzhou Medical University,Lishui,323000,China; 4.Department of Radiology,Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China
推荐引用方式 GB/T 7714	Tang, Bufu,Wang, Yajie,Zhu, Jinyu,et al. TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC[J]. BIOLOGICAL PROCEDURES ONLINE,2023,25(1).
APA	Tang, Bufu., Wang, Yajie., Zhu, Jinyu., Song, Jingjing., Fang, Shiji., ... & Ji, Jiansong. (2023). TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC. BIOLOGICAL PROCEDURES ONLINE, 25(1).
MLA	Tang, Bufu,et al."TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC".BIOLOGICAL PROCEDURES ONLINE 25.1(2023).