Effect of Lipoxin A(4) on Lipopolysaccharide-Induced Endothelial Hyperpermeability

doi:10.1100/tsw.2011.98

科研成果详情

题名	Effect of Lipoxin A(4) on Lipopolysaccharide-Induced Endothelial Hyperpermeability
作者	Pang, Huayan 1; Yi, Pan 2; Wu, Ping 2; Liu, Zhuoya 2; Liu, Zhongjie 1; Gong, Jianming1; Hao, Hua 2; Cai, Lei 2; Ye, Duyun 2; Huang, Yinping1
发表日期	2011-12-31
发表期刊	THESCIENTIFICWORLDJOURNAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	lipoxin endothelial permeability pre-eclampsia VE-cadherin Nrf2 oxidative stress
其他关键词	TRIGGERED 15-EPI-LIPOXIN A(4) ; NEUTROPHIL-MEDIATED CHANGES ; OXYGEN SPECIES PRODUCTION ; B-4 STABLE ANALOGS ; VASCULAR-PERMEABILITY ; OXIDATIVE STRESS ; INDUCED PROLIFERATION ; ADHESION MOLECULES ; JUNCTION PROTEINS ; LEUKOTRIENE D-4
摘要	Excessive oxidative stress, decreased antioxidant capacity, and enhanced cellular calcium levels are initial factors that cause endothelial cell (EC) hyperpermeability, which represents a crucial event in the pathogenesis of pre-eclampsia. Lipoxin A4 (LXA(4)) strongly attenuated lipopolysaccharide (LPS)-induced hyperpermeability through maintaining the normal expression of VE-cadherin and beta-catenin. This effect was mainly mediated by a specific LXA(4) receptor. LXA(4) could also obviously inhibit LPS-induced elevation of the cellular calcium level and up-regulation of the transient receptor potential protein family C 1, an important calcium channel in ECs. At the same time, LXA(4) strongly blocked LPS-triggered reactive oxidative species production, while it promoted the expression of the NF-E2 related factor 2 (Nrf2) protein. Our findings demonstrate that LXA(4) could prevent the EC hyperpermeability induced by LPS in human umbilical vein endothelial cells (HUVECs), under which the possible mechanism is through Nrf2 as well as Ca2+-sensitive pathways.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070510]; Natural Science Foundation of Wenzhou City, China [Y20090129]; Doctoral Fund of the Ministry of Education of ChinaMinistry of Education, China [200803430002]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	1537-744X
卷号	11 页码:1056-1067
DOI	10.1100/tsw.2011.98
页数	12
WOS类目	Environmental Sciences ; Multidisciplinary Sciences
WOS研究方向	Environmental Sciences & Ecology ; Science & Technology - Other Topics
WOS记录号	WOS:000310229700019
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	21552771
PMC记录号	PMC5719997
SCOPUSEID	2-s2.0-79958176472
通讯作者地址	[Huang, Yinping]Department of Obstetrics and Gynecology,Wenzhou Medical College,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all);Environmental Science (all)
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/18009
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_妇产科学
通讯作者	Huang, Yinping
作者单位	1.Department of Obstetrics and Gynecology,Wenzhou Medical College,China; 2.Department of Pathophysiology,Tongji Medical College,Huazhong University of Science and Technology,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Pang, Huayan,Yi, Pan,Wu, Ping,et al. Effect of Lipoxin A(4) on Lipopolysaccharide-Induced Endothelial Hyperpermeability[J]. THESCIENTIFICWORLDJOURNAL,2011,11:1056-1067.
APA	Pang, Huayan., Yi, Pan., Wu, Ping., Liu, Zhuoya., Liu, Zhongjie., ... & Huang, Yinping. (2011). Effect of Lipoxin A(4) on Lipopolysaccharide-Induced Endothelial Hyperpermeability. THESCIENTIFICWORLDJOURNAL, 11, 1056-1067.
MLA	Pang, Huayan,et al."Effect of Lipoxin A(4) on Lipopolysaccharide-Induced Endothelial Hyperpermeability".THESCIENTIFICWORLDJOURNAL 11(2011):1056-1067.