Long non-coding RNAs in breast cancer stem cells

doi:10.1007/s12032-023-02046-1

科研成果详情

题名	Long non-coding RNAs in breast cancer stem cells
作者	Huang, Yuting1,2; Mo, Wenju 2; Ding, Xiaowen 2; Ding, Yuqin 2
发表日期	2023-05-13
发表期刊	MEDICAL ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Long non-coding RNAs Breast cancer stem cells Self-renewal Tumor metastasis Tumor recurrence Therapy
其他关键词	EPITHELIAL-MESENCHYMAL TRANSITION ; TUMOR MICROENVIRONMENT ; EMBRYONIC STEM ; LINCRNA HOTAIR ; GENERATION ; HEDGEHOG ; MARKER ; MAINTENANCE ; ACTIVATION ; TRAITS
摘要	Breast cancer, one of the most commonly diagnosed cancers worldwide, is a heterogeneous disease with high rates of recurrence and metastasis that contribute to its high mortality rate. Breast cancer stem cells (BCSCs) are a small but significant subset of heterogeneous breast cancer cells that possess stem cell characteristics such as self-renewal and differentiation abilities that may drive metastasis and recurrence. Long non-coding RNAs (lncRNAs) are a class of RNAs that are longer than 200 nucleotides in length and do not possess protein-coding properties. An increasing number of studies have shown that some lncRNAs are abnormally expressed in BCSCs, and have great biological significance in the occurrence, progression, invasion, and metastasis of various cancers. However, the importance of lncRNAs, as well as the molecular mechanisms that regulate and promote the stemness of BCSCs, are still poorly understood. In the current review, we aim to summarize recent studies that highlight the role of lncRNAs in tumor occurrence and progression through BCSCs. In addition, the utility of lncRNAs as biomarkers of breast cancer progression, and their potential use as therapeutic targets for treatment of breast cancer, will be discussed.
资助项目	Natural Science Foundation of Zhejiang Province[LTGY23H160012,LTGY23H160015];Health Science and Technology Program of Zhejiang Province[2021KY566,2021RC041,2022RC014];
出版者	HUMANA PRESS INC
ISSN	1357-0560
EISSN	1559-131X
卷号	40 期号:6
DOI	10.1007/s12032-023-02046-1
页数	14
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000986405200002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37178429
SCOPUSEID	2-s2.0-85159740126
通讯作者地址	[Ding, Xiaowen]Department of Breast Surgery,Zhejiang Cancer Hospital,Hangzhou Institute of Medicine (HIM),Chinese Academy of Sciences,Zhejiang,Hangzhou,310022,China ; [Ding, Yuqin]Department of Breast Surgery,Zhejiang Cancer Hospital,Hangzhou Institute of Medicine (HIM),Chinese Academy of Sciences,Zhejiang,Hangzhou,310022,China
Scopus学科分类	Hematology;Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180096
专题	温州医科大学
通讯作者	Ding, Xiaowen; Ding, Yuqin
作者单位	1.Department of Oncology,Wenzhou Medical University,Wenzhou,325035,China; 2.Department of Breast Surgery,Zhejiang Cancer Hospital,Hangzhou Institute of Medicine (HIM),Chinese Academy of Sciences,Zhejiang,Hangzhou,310022,China
第一作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Huang, Yuting,Mo, Wenju,Ding, Xiaowen,et al. Long non-coding RNAs in breast cancer stem cells[J]. MEDICAL ONCOLOGY,2023,40(6).
APA	Huang, Yuting, Mo, Wenju, Ding, Xiaowen, & Ding, Yuqin. (2023). Long non-coding RNAs in breast cancer stem cells. MEDICAL ONCOLOGY, 40(6).
MLA	Huang, Yuting,et al."Long non-coding RNAs in breast cancer stem cells".MEDICAL ONCOLOGY 40.6(2023).