USP25 contributes to defective neurogenesis and cognitive impairments

doi:10.1096/fj.202300057R

科研成果详情

题名	USP25 contributes to defective neurogenesis and cognitive impairments
作者	Cai, Fang 1,2; Song, Beibei 2; Yang, Yi 1; Liao, Haikang1; Li, Ran 1; Wang, Zhao1; Cao, Ruixue1; Chen, Huaqiu 3; Wang, Juelu 2; Wu, Yili1; Zhang, Yun 3; Song, Weihong1,2,3
发表日期	2023-06
发表期刊	FASEB JOURNAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	cell cycle cognitive impairments Down's syndrome neurogenesis transgenic USP25
其他关键词	UBIQUITIN-SPECIFIC PROTEASE ; NEURAL STEM-CELLS ; ALZHEIMERS-DISEASE ; DEUBIQUITINATING ENZYME ; CYCLIN D1 ; PATHOGENESIS ; OVEREXPRESSION ; DEGRADATION ; EXPANSION ; NUMBER
摘要	Both Down syndrome (DS) individuals and animal models exhibit hypo-cellularity in hippocampus and neocortex indicated by enhanced neuronal death and compromised neurogenesis. Ubiquitin-specific peptidase 25 (USP25), a human chromosome 21 (HSA21) gene, encodes for a deubiquitinating enzyme overexpressed in DS patients. Dysregulation of USP25 has been associated with Alzheimer's phenotypes in DS, but its role in defective neurogenesis in DS has not been defined. In this study, we found that USP25 upregulation impaired cell cycle regulation during embryonic neurogenesis and cortical development. Overexpression of USP25 in hippocampus promoted the neural stem cells to glial cell fates and suppressed neuronal cell fate by altering the balance between cyclin D1 and cyclin D2, thus reducing neurogenesis in the hippocampus. USP25-Tg mice showed increased anxiety/depression-like behaviors and learning and memory deficits. These results suggested that USP25 overexpression resulted in defective neurogenesis and cognitive impairments, which could contribute to the pathogenesis of DS. USP25 may be a potential pharmaceutical target for DS.
资助项目	NSFC[82150710557,82293642];
出版者	WILEY
ISSN	0892-6638
EISSN	1530-6860
卷号	37 期号:6
DOI	10.1096/fj.202300057R
页数	14
WOS类目	Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS记录号	WOS:000986869900001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37171286
SCOPUSEID	2-s2.0-85159740432
通讯作者地址	[Cai, Fang]Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Key Laboratory of Alzheimer's Disease of Zhejiang Province,Zhejiang Provincial Clinical Research Center for Mental Disorders,Institute of Aging,School of Mental Health,the Affiliated Kangning Hospital,the Second Affiliated Hospital,Yuying Children's Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China ; [Song, Weihong]Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Key Laboratory of Alzheimer's Disease of Zhejiang Province,Zhejiang Provincial Clinical Research Center for Mental Disorders,Institute of Aging,School of Mental Health,Affiliated Kangning Hospital,The Second Affiliated Hospital,Yuying Children's Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Zhang, Yun]National Clinical Research Center for Geriatric Disorders,Xuanwu Hospital,Capital Medical University,Beijing,China
Scopus学科分类	Biotechnology;Biochemistry;Molecular Biology;Genetics
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180081
专题	卓越中心_老年研究院
通讯作者	Cai, Fang; Zhang, Yun; Song, Weihong
作者单位	1.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Key Laboratory of Alzheimer's Disease of Zhejiang Province,Zhejiang Provincial Clinical Research Center for Mental Disorders,Institute of Aging,School of Mental Health,Affiliated Kangning Hospital,The Second Affiliated Hospital,Yuying Children's Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Townsend Family Laboratories,Department of Psychiatry,Graduate Program in Neuroscience,Djavad Mowafaghian Centre for Brain Health,The University of British Columbia,Vancouver,Canada; 3.National Clinical Research Center for Geriatric Disorders,Xuanwu Hospital,Capital Medical University,Beijing,China
第一作者单位	卓越中心_老年研究院
通讯作者单位	卓越中心_老年研究院
第一作者的第一单位	卓越中心_老年研究院
推荐引用方式 GB/T 7714	Cai, Fang,Song, Beibei,Yang, Yi,et al. USP25 contributes to defective neurogenesis and cognitive impairments[J]. FASEB JOURNAL,2023,37(6).
APA	Cai, Fang., Song, Beibei., Yang, Yi., Liao, Haikang., Li, Ran., ... & Song, Weihong. (2023). USP25 contributes to defective neurogenesis and cognitive impairments. FASEB JOURNAL, 37(6).
MLA	Cai, Fang,et al."USP25 contributes to defective neurogenesis and cognitive impairments".FASEB JOURNAL 37.6(2023).