The distribution pattern of pelvic lymph nodal metastases in cervical cancer

doi:10.1007/s00432-023-04810-2

科研成果详情

题名	The distribution pattern of pelvic lymph nodal metastases in cervical cancer
作者	Xie, Shangdan 1; Zhao, Jing 1,2; Wang, Xintao 1; Hu, Yan2; Feng, Guannan 3; Zhu, Haiyan 1,2; Wang, Chao 1
发表日期	2023-09
发表期刊	JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Cervical cancer Pelvic lymph nodal Metastases Distribution
其他关键词	LYMPHADENECTOMY ; CARCINOMA
摘要	PurposeDepiction of pelvic lymph node metastasis (LNM) sites among patients with cervical cancer facilitates accurate determination of the extent of dissection and radiotherapy regimens.MethodsA retrospective study of 1182 cervical cancer patients who underwent radical hysterectomy and pelvic lymph node dissection between 2008 and 2018 was performed. The number of removed pelvic lymph nodes and metastasis status in different anatomical regions was analyzed. The prognostic difference of patients with lymph node involvement stratified by various factors was analyzed by Kaplan-Meier method.Results The median number of pelvic lymph nodes detected was 22, mainly from obturator (29.54%) and inguinal (21.14%) sites. Metastatic pelvic lymph nodes were found in 192 patients, with obturator accounting for the highest percentage (42.86%). The patients with lymph node involvement in single site had better prognosis that those in multiple sites. The overall- (P = 0.021) (OS) and progression-free (P < 0.001) survival (PFS) curves of patients with inguinal lymph node metastases were worse compared to those with obturator site. There was no difference in the OS and PFS among patients with 2 and more than 2 lymph nodes involvement.ConclusionAn explicit map of LNM in patients with cervical cancer was presented in this study. Obturator lymph nodes tended to be involved. The prognosis of patients with inguinal lymph node involvement was poor in contrast to that with obturator LNM. In patients with inguinal lymph node metastases, clinical staging needs to be reconsidered and extended radiotherapy to the inguinal region needs to be strengthened.
资助项目	Suzhou Science and Technology Development Project[SYS2020175];Suzhou Special Project of Diagnosis and Treatment for key Clinical Disease[LCZX202013];the Research Project of Gusu School of Nanjing Medical University[GSKY20210203];National Natural Science Foundation of China[82272778]
出版者	SPRINGER
ISSN	0171-5216
EISSN	1432-1335
卷号	149 期号:12 页码:9671-9677
DOI	10.1007/s00432-023-04810-2
页数	7
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000995856400001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-05
URL	查看原文
Pubmed记录号	37237167
Scopus记录号	2-s2.0-85160311239
通讯作者地址	[Zhu, Haiyan]Department of Gynecology,Shanghai First Maternity and Infant Hospital,School of Medicine,Tongji University,2699 Gaoke West Road,Shanghai,200092,China ; [Wang, Chao]Department of Gynecology,Shanghai First Maternity and Infant Hospital,School of Medicine,Tongji University,2699 Gaoke West Road,Shanghai,200092,China
scopus学科分类	Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180070
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_妇科附属第一医院
通讯作者	Zhu, Haiyan; Wang, Chao
作者单位	1.Department of Gynecology,Shanghai First Maternity and Infant Hospital,School of Medicine,Tongji University,2699 Gaoke West Road,Shanghai,200092,China; 2.Department of Gynecology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China; 3.Department of Gynecology,Gusu School,The Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Nanjing Medical University,Suzhou,211166,China
推荐引用方式 GB/T 7714	Xie, Shangdan,Zhao, Jing,Wang, Xintao,et al. The distribution pattern of pelvic lymph nodal metastases in cervical cancer[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2023,149(12):9671-9677.
APA	Xie, Shangdan., Zhao, Jing., Wang, Xintao., Hu, Yan., Feng, Guannan., ... & Wang, Chao. (2023). The distribution pattern of pelvic lymph nodal metastases in cervical cancer. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 149(12), 9671-9677.
MLA	Xie, Shangdan,et al."The distribution pattern of pelvic lymph nodal metastases in cervical cancer".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 149.12(2023):9671-9677.