Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey

doi:10.3389/fcvm.2023.945468

科研成果详情

题名	Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey
作者	Li, Li 1; Wang, Yuge 2; Yang, Chunlei 3; Huang, Chenhui 4; Duan, Lanzhi 2; Zhou, Jianghua5; Lu, Yanyu 3; Zhao, Guojun 3
发表日期	2023-04-25
发表期刊	FRONTIERS IN CARDIOVASCULAR MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	frailty pre-frailty mortality hypertension NHANES
其他关键词	HIGH BLOOD-PRESSURE ; ADULTS ; RISK
摘要	ObjectivesThis study aimed to investigate the relationship between frailty and all-cause mortality in hypertensive population.MethodsWe used data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002 and mortality data from the National Death Index. Frailty was assessed using the revised version of the Fried frailty criteria (weakness, exhaustion, low physical activity, shrinking, and slowness). This study aimed to evaluate the association between frailty and all-cause mortality. Cox proportional hazard models were used to evaluate the association between frailty category and all-cause mortality, adjusted for age, sex, race, education, poverty-income ratio, smoking, alcohol, diabetes, arthritis, congestive heart failure, coronary heart disease, stroke, overweight, cancer or malignancy, chronic obstructive pulmonary disease, chronic kidney disease, and taking medicine for hypertension.ResultsWe gathered data of 2,117 participants with hypertension; 17.81%, 28.77%, and 53.42% were classified as frail, pre-frail, and robust, respectively. We found that frail [hazard ratio (HR) = 2.76, 95% confidence interval (CI) = 2.33-3.27] and pre-frail (HR = 1.38, 95% CI = 1.19-1.59] were significantly associated with all-cause mortality after controlling for variables. We found that frail (HR = 3.02, 95% CI = 2.50-3.65) and pre-frail (HR = 1.35, 95% CI = 1.15-1.58) were associated with all-cause mortality in the age group >= 65 years. For the frailty components, weakness (HR = 1.77, 95% CI = 1.55-2.03), exhaustion (HR = 2.25, 95% CI = 1.92-2.65), low physical activity (HR = 2.25, 95% CI = 1.95-2.61), shrinking (HR = 1.48, 95% CI = 1.13-1.92), and slowness (HR = 1.44, 95% CI = 1.22-1.69) were associated with all-cause mortality.ConclusionThis study demonstrated that frailty and pre-frailty were associated with an increased risk of all-cause mortality in patients with hypertension. More attention should be paid to frailty in hypertensive patients, and interventions to reduce the burden of frailty may improve outcomes in these patients.
出版者	FRONTIERS MEDIA SA
ISSN	2297-055X
卷号	10
DOI	10.3389/fcvm.2023.945468
页数	8
WOS类目	Cardiac & Cardiovascular Systems
WOS研究方向	Cardiovascular System & Cardiology
WOS记录号	WOS:000983900600001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37180794
SCOPUSEID	2-s2.0-85158845038
通讯作者地址	[Zhao, Guojun]Department of Cardiology,The First Affliated Hospital of Zhengzhou University,Zhengzhou,China
Scopus学科分类	Cardiology and Cardiovascular Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180069
专题	护理学院温州医科大学
通讯作者	Zhao, Guojun
作者单位	1.Department of Cardiovascular Surgery,The First Affliated Hospital of Zhengzhou University,Zhengzhou,China; 2.Department of Medicine,Jinggangshan University,Ji'an,China; 3.Department of Cardiology,The First Affliated Hospital of Zhengzhou University,Zhengzhou,China; 4.College of Nursing,Wenzhou Medical University,Wenzhou,China; 5.Department of Cardiology,The First Affliated Hospital of Wenzhou Medical University,Wenzhou,China
推荐引用方式 GB/T 7714	Li, Li,Wang, Yuge,Yang, Chunlei,et al. Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey[J]. FRONTIERS IN CARDIOVASCULAR MEDICINE,2023,10.
APA	Li, Li., Wang, Yuge., Yang, Chunlei., Huang, Chenhui., Duan, Lanzhi., ... & Zhao, Guojun. (2023). Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey. FRONTIERS IN CARDIOVASCULAR MEDICINE, 10.
MLA	Li, Li,et al."Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey".FRONTIERS IN CARDIOVASCULAR MEDICINE 10(2023).