Comparison of the Early Warning Effects of Novel Inflammatory Markers SIRI, NLR, and LMR in the Inhibition of Carotid Atherosclerosis by Testosterone in Middle-Aged and Elderly Han Chinese Men in the Real World: A Small Sample Clinical Observational Study

doi:10.1177/15579883231171462

科研成果详情

题名	Comparison of the Early Warning Effects of Novel Inflammatory Markers SIRI, NLR, and LMR in the Inhibition of Carotid Atherosclerosis by Testosterone in Middle-Aged and Elderly Han Chinese Men in the Real World: A Small Sample Clinical Observational Study
作者	Chen, Qinhao 1,4; Che, Mingzhu2; Shen, Wei 3; Shao, Lijie 1; Yu, Haiyang 4; Zhou, Jian 1,5
发表日期	2023-05
发表期刊	AMERICAN JOURNAL OF MENS HEALTH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	atherosclerosis bioavailable testosterone systemic inflammation response index neutrophil-lymphocyte ratio lymphocyte-to-monocyte ratio
其他关键词	CELL-ADHESION MOLECULE-1 ; C-REACTIVE PROTEIN ; LYMPHOCYTE RATIO ; CARDIOVASCULAR-DISEASES ; ENDOTHELIAL-CELLS ; NEUTROPHIL ; RISK ; EXPRESSION ; RECEPTOR ; REPLACEMENT
摘要	The purpose of this study was to explore and compare the relationship among serum testosterone, systemic inflammatory response index (SIRI), lymphocyte-to-monocyte ratio (LMR) neutrophil-lymphocyte ratio (NLR), and carotid atherosclerosis in middle-aged and elderly men of Han nationality in the real world. With reference to the inclusion criteria, 89 middle-aged and elderly Han male patients were finally selected. Local weighted regression (LOESS) and multivariate logistic regression models were used to explore the independent correlation between serum testosterone, new inflammatory markers, and atherosclerosis. The diagnostic value of related indexes was evaluated by the receiver working curve characteristic curve (ROC), and the best critical value of testosterone and related inflammatory indexes was discussed. In the LOESS model, bioavailable testosterone (BT), free testosterone (FT), total testosterone (TT) and SIRI, NLR, LMR, and atherosclerosis were significantly correlated. After adjusting for confounding factors, BT, FT, TT, and LMR were negatively correlated with atherosclerosis (odds ratio [OR] < 1, p < .05), and SIRI and NLR were positively associated with atherosclerosis (OR > 1, p < .05). According to the ROC curve results, the area under the curve (AUG) of BT is 0.870, and the optimal threshold point is 4.875. The AUG of SIRI is 0.864, and the best threshold point is 0.769. Low testosterone and high inflammatory levels are closely related to atherosclerosis. Testosterone (TT, FT, and BT) and new inflammatory markers, SIRI, NLR, and LMR, are associated with carotid atherosclerosis in middle-aged and elderly men.
出版者	SAGE PUBLICATIONS INC
ISSN	1557-9883
EISSN	1557-9891
卷号	17 期号:3
DOI	10.1177/15579883231171462
页数	11
WOS类目	Public, Environmental & Occupational Health
WOS研究方向	Public, Environmental & Occupational Health
WOS记录号	WOS:000987163100001
收录类别	SSCI ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37183913
SCOPUSEID	2-s2.0-85159234622
社科自定义期刊分类	F类
通讯作者地址	[Zhou, Jian]Department of Geriatrics,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Anhui,Hefei,China
Scopus学科分类	Health (social science);Public Health, Environmental and Occupational Health
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180033
专题	公共卫生学院
通讯作者	Zhou, Jian
作者单位	1.Department of Geriatrics,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Anhui,Hefei,China; 2.Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Wenzhou,China; 3.Department of International Medical,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Anhui,Hefei,China; 4.Department of Oncology,Provincial Hospital,Anhui Medical University,Anhui,Hefei,China; 5.Department of Geriatrics,Wannan Medical College,Anhui,Wuhu,China
推荐引用方式 GB/T 7714	Chen, Qinhao,Che, Mingzhu,Shen, Wei,et al. Comparison of the Early Warning Effects of Novel Inflammatory Markers SIRI, NLR, and LMR in the Inhibition of Carotid Atherosclerosis by Testosterone in Middle-Aged and Elderly Han Chinese Men in the Real World: A Small Sample Clinical Observational Study[J]. AMERICAN JOURNAL OF MENS HEALTH,2023,17(3).
APA	Chen, Qinhao, Che, Mingzhu, Shen, Wei, Shao, Lijie, Yu, Haiyang, & Zhou, Jian. (2023). Comparison of the Early Warning Effects of Novel Inflammatory Markers SIRI, NLR, and LMR in the Inhibition of Carotid Atherosclerosis by Testosterone in Middle-Aged and Elderly Han Chinese Men in the Real World: A Small Sample Clinical Observational Study. AMERICAN JOURNAL OF MENS HEALTH, 17(3).
MLA	Chen, Qinhao,et al."Comparison of the Early Warning Effects of Novel Inflammatory Markers SIRI, NLR, and LMR in the Inhibition of Carotid Atherosclerosis by Testosterone in Middle-Aged and Elderly Han Chinese Men in the Real World: A Small Sample Clinical Observational Study".AMERICAN JOURNAL OF MENS HEALTH 17.3(2023).