Computational markers of risky decision-making predict for relapse to alcohol

doi:10.1007/s00406-023-01602-0

科研成果详情

题名	Computational markers of risky decision-making predict for relapse to alcohol
作者	Yuan, Wei 1; Chen, Meng 2; Wang, Duan-Wei 1; Li, Qian-Hui 3; Yin, Yuan-Yuan4; Li, Bin 1; Wang, Hai-Rong 1; Hu, Ji 5; Gong, Yuan-Dong 1; Yuan, Ti-Fei 6,7; Yu, Tian-Gui 1
发表日期	2023-05-06
发表期刊	EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Alcohol relapse Risk-taking Balloon analog risk task Computational modeling
其他关键词	PSYCHOMETRIC PROPERTIES ; RESPONSE-INHIBITION ; BEHAVIORAL MEASURES ; TAKING PROPENSITY ; BIPOLAR DISORDER ; UNITED-STATES ; IMPULSIVITY ; INDIVIDUALS ; PREVALENCE ; DEPENDENCE
摘要	BackgroundRelapse remains the major challenge in treatment of alcohol use disorder (AUD). Aberrant decision-making has been found as important cognitive mechanism underlying relapse, but factors associated with relapse vulnerability are unclear. Here, we aim to identify potential computational markers of relapse vulnerability by investigating risky decision-making in individuals with AUD.MethodsForty-six healthy controls and fifty-two individuals with AUD were recruited for this study. The risk-taking propensity of these subjects was investigated using the balloon analog risk task (BART). After completion of clinical treatment, all individuals with AUD were followed up and divided into a non-relapse AUD group and a relapse AUD group according to their drinking status.ResultsThe risk-taking propensity differed significantly among healthy controls, the non-relapse AUD group, and the relapse AUD group, and was negatively associated with the duration of abstinence in individuals with AUD. Logistic regression models showed that risk-taking propensity, as measured by the computational model, was a valid predictor of alcohol relapse, and higher risk-taking propensity was associated with greater risk of relapse to drink.ConclusionOur study presents new insights into risk-taking measurement and identifies computational markers that provide prospective information for relapse to drink in individuals with AUD.
资助项目	Shandong Mental Health Center grant
出版者	SPRINGER HEIDELBERG
ISSN	0940-1334
EISSN	1433-8491
卷号	274 期号:2 页码:353-362
DOI	10.1007/s00406-023-01602-0
页数	10
WOS类目	Clinical Neurology ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS记录号	WOS:000982772800001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	37148307
SCOPUSEID	2-s2.0-85158081160
通讯作者地址	[Gong, Yuan-Dong]Department of Addiction Medicine,Shandong Mental Health Center,Jinan,250014,China ; [Yu, Tian-Gui]Department of Addiction Medicine,Shandong Mental Health Center,Jinan,250014,China ; [Yuan, Ti-Fei]Shanghai Key Laboratory of Psychotic Disorders,Brain Health Institute,National Center for Mental Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China
Scopus学科分类	Psychiatry and Mental Health;Biological Psychiatry;Pharmacology (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/180020
专题	精神医学学院
通讯作者	Gong, Yuan-Dong; Yuan, Ti-Fei; Yu, Tian-Gui
作者单位	1.Department of Addiction Medicine,Shandong Mental Health Center,Jinan,250014,China; 2.Brain and Cognitive Neuroscience Research Center,Liaoning Normal University,Dalian,116029,China; 3.Division of Gastroenterology,Seventh Affiliated Hospital of Sun Yat-Sen University,Shenzhen,518107,China; 4.School of Mental Health,Wenzhou Medical University,Wenzhou,325035,China; 5.School of Life Science and Technology,ShanghaiTech University,Shanghai,201210,China; 6.Shanghai Key Laboratory of Psychotic Disorders,Brain Health Institute,National Center for Mental Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China; 7.Co-Innovation Center of Neuroregeneration,Nantong University,Jiangsu,Nantong,China
推荐引用方式 GB/T 7714	Yuan, Wei,Chen, Meng,Wang, Duan-Wei,et al. Computational markers of risky decision-making predict for relapse to alcohol[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2023,274(2):353-362.
APA	Yuan, Wei., Chen, Meng., Wang, Duan-Wei., Li, Qian-Hui., Yin, Yuan-Yuan., ... & Yu, Tian-Gui. (2023). Computational markers of risky decision-making predict for relapse to alcohol. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 274(2), 353-362.
MLA	Yuan, Wei,et al."Computational markers of risky decision-making predict for relapse to alcohol".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 274.2(2023):353-362.