科研成果详情

题名Derivation and validation of a novel score for early prediction of severe CRS after CAR-T therapy in haematological malignancy patients: A multi-centre study
作者
发表日期2023-08
发表期刊BRITISH JOURNAL OF HAEMATOLOGY   影响因子和分区
语种英语
原始文献类型Article ; Early Access
关键词CAR-T cell therapy cytokine release syndrome early prediction haematological malignancies
其他关键词CYTOKINE RELEASE SYNDROME ; CELL THERAPY ; MANAGEMENT ; BIOMARKERS ; CHILDREN ; ADULTS
摘要Chimeric antigen receptor T (CAR-T) cell therapy is highly effective in inducing complete remission in haematological malignancies. Severe cytokine release syndrome (CRS) is the most significant and life-threatening adverse effect of this therapy. This multi-centre study was conducted at six hospitals in China. The training cohort included 87 patients with multiple myeloma (MM), an external validation cohort of 59 patients with MM and another external validation cohort of 68 patients with acute lymphoblastic leukaemia (ALL) or non-Hodgkin lymphoma (NHL). The levels of 45 cytokines on days 1-2 after CAR-T cell infusion and clinical characteristics of patients were used to develop the nomogram. A nomogram was developed, including CX3CL1, GZMB, IL4, IL6 and PDGFAA. Based on the training cohort, the nomogram had a bias-corrected AUC of 0.876 (95% CI = 0.871-0.882) for predicting severe CRS. The AUC was stable in both external validation cohorts (MM, AUC = 0.907, 95% CI = 0.899-0.916; ALL/NHL, AUC = 0.908, 95% CI = 0.903-0.913). The calibration plots (apparent and bias-corrected) overlapped with the ideal line in all cohorts. We developed a nomogram that can predict which patients are likely to develop severe CRS before they become critically ill, improving our understanding of CRS biology, and may guide future cytokine-directed therapies.
资助项目Natural Science Foundation of China[81970137,82130003];Sanming Project of Medicine in Shenzhen[SZSM202111004];Zhejiang Science and Technology Department[2021C03010];
出版者WILEY
ISSN0007-1048
EISSN1365-2141
卷号202期号:3页码:517-524
DOI10.1111/bjh.18873
页数8
WOS类目Hematology
WOS研究方向Hematology
WOS记录号WOS:000989058900001
收录类别SCIE ; PUBMED ; SCOPUS
在线发表日期2023-05
URL查看原文
PubMed ID37192741
SCOPUSEID2-s2.0-85159325417
通讯作者地址[Wei, Guoqing]Bone Marrow Transplantation Center,The First Affiliated Hospital,School of Medicine,Zhejiang University,No. 79 Qingchun Road,Hangzhou,China ; [Hu, Yongxian]Bone Marrow Transplantation Center,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China ; [Huang, He]Bone Marrow Transplantation Center,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China
Scopus学科分类Hematology
TOP期刊TOP期刊
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/180018
专题其他_定理临床学院(温州市中心医院)
通讯作者Wei, Guoqing; Hu, Yongxian; Huang, He
作者单位
1.Bone Marrow Transplantation Center,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China;
2.Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou,China;
3.Institute of Hematology,Zhejiang University,Hangzhou,China;
4.Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy,Hangzhou,China;
5.Department of Hematology,Shanghai Fourth People's Hospital,School of Medicine,Tongji University,Shanghai,China;
6.Department of Hematology,The Dingli Clinical College of Wenzhou Medical University (The Second Affiliated Hospital of Shanghai University,Wenzhou Central Hospital),Zhejiang,China;
7.Blood Diseases Institute,Xuzhou Medical University,Xuzhou,China;
8.Department of Hematology,The Affiliated Hospital of Xuzhou Medical University,Xuzhou,China;
9.National Clinical Research Center for Blood Diseases,State Key Laboratory of Experimental Hematology,Blood Diseases & Institute of Hematology,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,China;
10.Department of Hematology,The Second Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China;
11.Department of Hematology,The First Affiliated Hospital of China Medical University,Shenyang,China;
12.Guangdong Second Provincial General Hospital,Guangzhou,China;
13.Shanghai YaKe Biotechnology Ltd,Shanghai,China;
14.Clinical Translational Research Center,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai,China
推荐引用方式
GB/T 7714
Zhou, Linghui,Fu, Weijun,Wu, Shenghao,et al. Derivation and validation of a novel score for early prediction of severe CRS after CAR-T therapy in haematological malignancy patients: A multi-centre study[J]. BRITISH JOURNAL OF HAEMATOLOGY,2023,202(3):517-524.
APA Zhou, Linghui., Fu, Weijun., Wu, Shenghao., Xu, Kailin., Qiu, Lugui., ... & Huang, He. (2023). Derivation and validation of a novel score for early prediction of severe CRS after CAR-T therapy in haematological malignancy patients: A multi-centre study. BRITISH JOURNAL OF HAEMATOLOGY, 202(3), 517-524.
MLA Zhou, Linghui,et al."Derivation and validation of a novel score for early prediction of severe CRS after CAR-T therapy in haematological malignancy patients: A multi-centre study".BRITISH JOURNAL OF HAEMATOLOGY 202.3(2023):517-524.

条目包含的文件

条目无相关文件。
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Zhou, Linghui]的文章
[Fu, Weijun]的文章
[Wu, Shenghao]的文章
百度学术
百度学术中相似的文章
[Zhou, Linghui]的文章
[Fu, Weijun]的文章
[Wu, Shenghao]的文章
必应学术
必应学术中相似的文章
[Zhou, Linghui]的文章
[Fu, Weijun]的文章
[Wu, Shenghao]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。