题名 | Derivation and validation of a novel score for early prediction of severe CRS after CAR-T therapy in haematological malignancy patients: A multi-centre study |
作者 | Zhou, Linghui1,2,3,4; Fu, Weijun5; Wu, Shenghao1,6; Xu, Kailin7,8; Qiu, Lugui9; Xu, Yang10; Yan, Xiaojing11; Zhang, Qing12; Zhang, Mingming1,2,3,4; Wang, Linqin1,2,3,4; Hong, Ruimin1,2,3,4; Chang, Alex H.13,14; Yu, Jian1,2,3,4; Fu, Shan1,2,3,4; Kong, Delin1,2,3,4; Li, Lu5; Wang, Ying7,8; Li, Zhenyu7,8; Jiang, Huawei10; Huang, Jing12; Liu, Zhi12; Su, Na11; Wei, Guoqing1,2,3,4; Hu, Yongxian1,2,3,4; Huang, He1,2,3,4
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发表日期 | 2023-08 |
发表期刊 | BRITISH JOURNAL OF HAEMATOLOGY 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article ; Early Access |
关键词 | CAR-T cell therapy cytokine release syndrome early prediction haematological malignancies |
其他关键词 | CYTOKINE RELEASE SYNDROME ; CELL THERAPY ; MANAGEMENT ; BIOMARKERS ; CHILDREN ; ADULTS |
摘要 | Chimeric antigen receptor T (CAR-T) cell therapy is highly effective in inducing complete remission in haematological malignancies. Severe cytokine release syndrome (CRS) is the most significant and life-threatening adverse effect of this therapy. This multi-centre study was conducted at six hospitals in China. The training cohort included 87 patients with multiple myeloma (MM), an external validation cohort of 59 patients with MM and another external validation cohort of 68 patients with acute lymphoblastic leukaemia (ALL) or non-Hodgkin lymphoma (NHL). The levels of 45 cytokines on days 1-2 after CAR-T cell infusion and clinical characteristics of patients were used to develop the nomogram. A nomogram was developed, including CX3CL1, GZMB, IL4, IL6 and PDGFAA. Based on the training cohort, the nomogram had a bias-corrected AUC of 0.876 (95% CI = 0.871-0.882) for predicting severe CRS. The AUC was stable in both external validation cohorts (MM, AUC = 0.907, 95% CI = 0.899-0.916; ALL/NHL, AUC = 0.908, 95% CI = 0.903-0.913). The calibration plots (apparent and bias-corrected) overlapped with the ideal line in all cohorts. We developed a nomogram that can predict which patients are likely to develop severe CRS before they become critically ill, improving our understanding of CRS biology, and may guide future cytokine-directed therapies. |
资助项目 | Natural Science Foundation of China[81970137,82130003];Sanming Project of Medicine in Shenzhen[SZSM202111004];Zhejiang Science and Technology Department[2021C03010]; |
出版者 | WILEY |
ISSN | 0007-1048 |
EISSN | 1365-2141 |
卷号 | 202期号:3页码:517-524 |
DOI | 10.1111/bjh.18873 |
页数 | 8 |
WOS类目 | Hematology |
WOS研究方向 | Hematology |
WOS记录号 | WOS:000989058900001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
在线发表日期 | 2023-05 |
URL | 查看原文 |
PubMed ID | 37192741 |
SCOPUSEID | 2-s2.0-85159325417 |
通讯作者地址 | [Wei, Guoqing]Bone Marrow Transplantation Center,The First Affiliated Hospital,School of Medicine,Zhejiang University,No. 79 Qingchun Road,Hangzhou,China ; [Hu, Yongxian]Bone Marrow Transplantation Center,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China ; [Huang, He]Bone Marrow Transplantation Center,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China |
Scopus学科分类 | Hematology |
TOP期刊 | TOP期刊 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/180018 |
专题 | 其他_定理临床学院(温州市中心医院) |
通讯作者 | Wei, Guoqing; Hu, Yongxian; Huang, He |
作者单位 | 1.Bone Marrow Transplantation Center,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China; 2.Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou,China; 3.Institute of Hematology,Zhejiang University,Hangzhou,China; 4.Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy,Hangzhou,China; 5.Department of Hematology,Shanghai Fourth People's Hospital,School of Medicine,Tongji University,Shanghai,China; 6.Department of Hematology,The Dingli Clinical College of Wenzhou Medical University (The Second Affiliated Hospital of Shanghai University,Wenzhou Central Hospital),Zhejiang,China; 7.Blood Diseases Institute,Xuzhou Medical University,Xuzhou,China; 8.Department of Hematology,The Affiliated Hospital of Xuzhou Medical University,Xuzhou,China; 9.National Clinical Research Center for Blood Diseases,State Key Laboratory of Experimental Hematology,Blood Diseases & Institute of Hematology,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,China; 10.Department of Hematology,The Second Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China; 11.Department of Hematology,The First Affiliated Hospital of China Medical University,Shenyang,China; 12.Guangdong Second Provincial General Hospital,Guangzhou,China; 13.Shanghai YaKe Biotechnology Ltd,Shanghai,China; 14.Clinical Translational Research Center,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai,China |
推荐引用方式 GB/T 7714 | Zhou, Linghui,Fu, Weijun,Wu, Shenghao,et al. Derivation and validation of a novel score for early prediction of severe CRS after CAR-T therapy in haematological malignancy patients: A multi-centre study[J]. BRITISH JOURNAL OF HAEMATOLOGY,2023,202(3):517-524. |
APA | Zhou, Linghui., Fu, Weijun., Wu, Shenghao., Xu, Kailin., Qiu, Lugui., ... & Huang, He. (2023). Derivation and validation of a novel score for early prediction of severe CRS after CAR-T therapy in haematological malignancy patients: A multi-centre study. BRITISH JOURNAL OF HAEMATOLOGY, 202(3), 517-524. |
MLA | Zhou, Linghui,et al."Derivation and validation of a novel score for early prediction of severe CRS after CAR-T therapy in haematological malignancy patients: A multi-centre study".BRITISH JOURNAL OF HAEMATOLOGY 202.3(2023):517-524. |
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