Bifidobacterium longum R0175 Protects Rats against D-Galactosamine-Induced Acute Liver Failure

doi:10.1128/mSphere.00791-19

科研成果详情

题名	Bifidobacterium longum R0175 Protects Rats against D-Galactosamine-Induced Acute Liver Failure
作者	Wang, Kaicen 1,2,3; Lv, Longxian 1,2,3; Yan, Ren 1,2,3; Wang, Qiangqiang 1,2,3; Jiang, Huiyong 1,2,3; Wu, Wenrui 1,2,3; Li, Yating 1,2,3; Ye, Jianzhong1,2,3,4; Wu, Jingjing 1,2,3; Yang, Liya 1,2,3; Bian, Xiaoyuan 1,2,3; Jiang, Xianwan 1,2,3; Lu, Yanmeng 1,2,3; Xie, Jiaojiao 1,2,3; Wang, Qing 1,2,3; Shen, Jian 1,2,3; Li, Lanjuan 1,2,3
发表日期	2020
发表期刊	MSPHERE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Bifidobacterium longum R0175 acute liver failure metabolome microbiome probiotic
其他关键词	BUTYRICIMONAS-VIROSA BACTEREMIA ; LACTOBACILLUS-HELVETICUS R0052 ; IMMUNE-RESPONSE ; GUT FLORA ; FORMULATION ; METHIONINE ; HEALTH ; METABOLISM ; MICROBIOTA ; CELLS
摘要	Acute liver failure is a severe liver disorder that poses considerable global challenges. Previous studies on Bifidobacterium longum R0175 have mainly focused on its psychotropic functions. The current research focused on the protective efficacy of B. longum R0175 against acute liver failure caused by D-galactosamine (D-GalN) in rats and further tested the hypothesis that B. longum R0175 exerted liver-protective effects by affecting the intestinal microbiota and fecal metabolites and by inhibiting inflammation. We found that oral gavage of B. longum R0175 markedly reduced the severity of liver injury in D-GalN-treated rats, as evidenced by decreased serum levels of aspartate aminotransferase (AST) and total bile acids (TBAs) (P < 0.05). Moreover, the plasma concentrations of proinflammatory cytokines (interleukin 1 beta [IL-1 beta] and tumor necrosis factor-alpha [TNF-alpha]) and chemokines (granulocyte-macrophage colony-stimulating factor [GM-CSF], macrophage chemoattractant protein 1 [MCP-1], chemokine [C-X-C motif] ligand 1 [CXCL1], chemokine [C-C motif] ligand 5 [CCL5], and macrophage inflammatory protein-1 alpha [MIP-1 alpha]) were also markedly reduced (P < 0.05). Pretreatment with B. longum R0175 partially reversed the gut microbiota dysbiosis in rats with liver injury by increasing the relative abundances of potentially beneficial bacteria, such as Alloprevotella spp., and decreasing the relative abundances of potentially harmful bacteria, such as Acetatifactor muris, Butyricimonas spp., and Oscillibacter spp. Furthermore, B. longum R0175 administration partially improved the metabolic function of the intestinal microbes, as indicated by the decreased level of lithocholic acid found in the feces. IMPORTANCE Our research investigated the protective and preventive roles of B. longum R0175 in a rat model of acute liver failure. The results illustrated that this probiotic strain exhibited protective effects in rats with acute liver failure. Thus, B. longum R0175 showed clinical application prospects that required further exploration.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81790631, 81570512]; National Key Research and Development Program of China [2018YFC2000500]; Natural Science Foundation of Zhejiang Province, ChinaNatural Science Foundation of Zhejiang Province [LQ19H030007]
出版者	AMER SOC MICROBIOLOGY
出版地	WASHINGTON
ISSN	2379-5042
EISSN	2379-5042
卷号	5 期号:1
DOI	10.1128/mSphere.00791-19
页数	14
WOS类目	Microbiology
WOS研究方向	Microbiology
WOS记录号	WOS:000510849900024
收录类别	SCIE ; SCOPUS
URL	查看原文
Pubmed记录号	31996423
Scopus记录号	2-s2.0-85078690450
通讯作者地址	[Li, Lanjuan]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China
scopus学科分类	Microbiology;Molecular Biology
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17768
专题	附属第一医院_检验科
通讯作者	Li, Lanjuan
作者单位	1.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China; 2.National Clinical Research Center for Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China; 3.Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China; 4.Department of Laboratory,The First Affiliated Hospital of Wenzhou Medical College,Wenzhou,China
推荐引用方式 GB/T 7714	Wang, Kaicen,Lv, Longxian,Yan, Ren,et al. Bifidobacterium longum R0175 Protects Rats against D-Galactosamine-Induced Acute Liver Failure[J]. MSPHERE,2020,5(1).
APA	Wang, Kaicen., Lv, Longxian., Yan, Ren., Wang, Qiangqiang., Jiang, Huiyong., ... & Li, Lanjuan. (2020). Bifidobacterium longum R0175 Protects Rats against D-Galactosamine-Induced Acute Liver Failure. MSPHERE, 5(1).
MLA	Wang, Kaicen,et al."Bifidobacterium longum R0175 Protects Rats against D-Galactosamine-Induced Acute Liver Failure".MSPHERE 5.1(2020).