Establishment of mus skin photo-damage model by 8-MOP plus UVA irradiation

doi:10.1007/s11596-007-0633-9

科研成果详情

题名	Establishment of mus skin photo-damage model by 8-MOP plus UVA irradiation
作者	Liang Hong 1; Li Hawen 1; Zhang Li 2
发表日期	2007-12
发表期刊	JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	skin photodamage 8-MOP/UVA animal model
摘要	To establish a simple and reliable animal model of skin photo-damage, 20 mice were treated with 8-MOP and exposed to UVA (UVA 320-400 nm) for 24 h. After irradiation, the structure of the epidermis and dermis, collagen fibers, elastic fibers were observed by using HE staining and Weigert technique and compared with the normal controls. The acanthosis and epidermis proliferation with accompanying hyperkeratosis and parakeratosis were observed. Inflammatory infiltration was noted in the dermis. The elastic fibers became coarse, irregularly arranged and clustered, with their number increased. The collagen fibers showed obvious degeneration and some amorphous materials could also be observed. The blood vessels were irregularly dilated and vascular walls were thickened, with infiltration of inflammatory cells. It is concluded that murine photodamage model can be quickly, conveniently and reliably established by means of 8-MOP/UVA.
资助项目	Natural Science Foundation of Hubei Province[302131041];
出版者	SPRINGER
出版地	NEW YORK
ISSN	1672-0733
卷号	27 期号:6 页码:742-744
DOI	10.1007/s11596-007-0633-9
页数	3
WOS类目	Biochemistry & Molecular Biology
WOS研究方向	Biochemistry & Molecular Biology
WOS记录号	WOS:000255543000033
收录类别	SCIE ; SCOPUS
URL	查看原文
Pubmed记录号	18231759
Scopus记录号	2-s2.0-38849203255
通讯作者地址	[Li Hawen]Huazhong Univ Sci & Technol, Dept Dermatol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China.
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17740
专题	附属第一医院_皮肤科
通讯作者	Li Hawen
作者单位	1.Huazhong Univ Sci & Technol, Dept Dermatol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China; 2.Wenzhou Med Coll, Dept Dermatol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
推荐引用方式 GB/T 7714	Liang Hong,Li Hawen,Zhang Li. Establishment of mus skin photo-damage model by 8-MOP plus UVA irradiation[J]. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES,2007,27(6):742-744.
APA	Liang Hong, Li Hawen, & Zhang Li. (2007). Establishment of mus skin photo-damage model by 8-MOP plus UVA irradiation. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 27(6), 742-744.
MLA	Liang Hong,et al."Establishment of mus skin photo-damage model by 8-MOP plus UVA irradiation".JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 27.6(2007):742-744.