Pharmacokinetic profile of 2,3,5,4 '-tetrahydroxystilbene-2-O-beta-D-glucoside in mice after oral administration of Polygonum multiflorum extract

doi:10.3109/03639045.2011.597763

科研成果详情

题名	Pharmacokinetic profile of 2,3,5,4 '-tetrahydroxystilbene-2-O-beta-D-glucoside in mice after oral administration of Polygonum multiflorum extract
作者	Lv, Guiyuan 1,2; Gu, Hui 1; Chen, Suhong2; Lou, Zhaohuan 1; Shan, Letian 1
发表日期	2012-02
发表期刊	DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Pharmacokinetics stilbene glycoside traditional Chinese medicine RP-HPLC compartmental model
其他关键词	LIGHT-SCATTERING DETECTION ; LIQUID-CHROMATOGRAPHY ; ANTIOXIDANT ACTIVITIES ; IN-VITRO ; THUNB ; STILBENE ; CONSTITUENTS ; COMPONENTS ; ROOTS ; VIVO
摘要	Context: Stilbene glycoside (2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside) is a main bioactive component of Polygonum multiflorum, a traditional Chinese medicine (TCM) commonly used in clinic for anti-aging treatment. Its medicinal activities, such as anti-oxidation, anti-inflammation and endothelial protection, have been extensively studied, but its pharmacokinetic property is still unclear. Objective: A pharmacokinetic study was undertaken to quantitatively determine P. multiflorum stilbene glycoside (PM-SG) in mouse plasma after oral administration of 100 mg/kg P. multiflorum extract. Materials and methods: A sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) coupled with liquid-liquid phase extraction method was employed for this study. Pharmacokinetic parameters of PM-SG were determined in mice applying both compartmental and non-compartmental analyses. Results and discussion: The calibration curve for PM-SG in the plasma was linear (r(2) > 0.99) over the range of 0.66 to 56.40 mu g/ml, and the concentration-time curve was plotted with the maximum concentration (C-max) and time to reach maximum concentration (T-max) of 29.62 mu g/ml and 60 min, respectively. The intra-and inter-day variations were less than 3% for relative standard deviation (RSD) and relative error (RE), with a good recovery of more than 97% (RSD <3%). All pharmacokinetic parameters estimated by compartmental and non-compartmental models reached a same conclusion that PM-SG was rapidly absorbed and widely distributed throughout the body with a great efficiency of utility, followed by quick elimination and clearance. Conclusions: This was the first report on determination of the pharmacokinetic profile of PM-SG in mice after oral administration. The result may provide a meaningful basis for evaluating the clinical applications of such a bioactive compound from herbal medicines.
资助项目	Science and Technology Department of Zhejiang Province of China [2002C23030]
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	0363-9045
EISSN	1520-5762
卷号	38 期号:2 页码:248-255
DOI	10.3109/03639045.2011.597763
页数	8
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000298356600010
收录类别	SCIE ; SCOPUS
URL	查看原文
Pubmed记录号	21892876
Scopus记录号	2-s2.0-84255182794
自科自定义期刊分类	T3(B)类
通讯作者地址	[Chen, Suhong]Academy of Traditional Chinese Medicine,Wenzhou Medical College,China
scopus学科分类	Pharmacology;Pharmaceutical Science;Drug Discovery;Organic Chemistry
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17730
专题	第一临床医学院（信息与工程学院）、附属第一医院_中医学
通讯作者	Chen, Suhong
作者单位	1.Zhejiang Chinese Medical University,China; 2.Academy of Traditional Chinese Medicine,Wenzhou Medical College,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
推荐引用方式 GB/T 7714	Lv, Guiyuan,Gu, Hui,Chen, Suhong,et al. Pharmacokinetic profile of 2,3,5,4 '-tetrahydroxystilbene-2-O-beta-D-glucoside in mice after oral administration of Polygonum multiflorum extract[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2012,38(2):248-255.
APA	Lv, Guiyuan, Gu, Hui, Chen, Suhong, Lou, Zhaohuan, & Shan, Letian. (2012). Pharmacokinetic profile of 2,3,5,4 '-tetrahydroxystilbene-2-O-beta-D-glucoside in mice after oral administration of Polygonum multiflorum extract. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 38(2), 248-255.
MLA	Lv, Guiyuan,et al."Pharmacokinetic profile of 2,3,5,4 '-tetrahydroxystilbene-2-O-beta-D-glucoside in mice after oral administration of Polygonum multiflorum extract".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 38.2(2012):248-255.