Predation Efficacy of Bdellovibrio bacteriovorus on Multidrug-Resistant Clinical Pathogens and Their Corresponding Biofilms

doi:10.7883/yoken.JJID.2016.405

科研成果详情

题名	Predation Efficacy of Bdellovibrio bacteriovorus on Multidrug-Resistant Clinical Pathogens and Their Corresponding Biofilms
作者	Sun, Yao 1; Ye, Jianzhong 2,3; Hou, Yuanbo 4; Chen, Huale 1; Cao, Jianming4; Zhou, Tieli1
发表日期	2017-09
发表期刊	JAPANESE JOURNAL OF INFECTIOUS DISEASES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Bdellovibrio bacteriovorus antimicrobials biofilms resistance.
其他关键词	ESCHERICHIA-COLI ; INFECTIONS ; STRAINS ; FISH ; 109J
摘要	The aim of the present study was to evaluate the predation efficacy of Bdellovibrio bacteriovorus on multidrug-resistant (MDR) or extensive drug resistant (XDR) gram-negative pathogens and their corresponding biofilms. In this study, we examined the ability of B. bacteriovorus to prey on MDR and XDR gram-negative clinical bacteria, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Results showed that B. bacteriovorus was able to prey on all planktonic cultures, among which the most efficient predation was observed for drug resistant E. coli, with a 3.11 log10 reduction in viability. Furthermore, B. bacteriovorus demonstrated promising efficacy in preventing biofilm formation and dispersing the established biofilm Reductions in biofilm formation of E. coli, K. pneumoniae, P. aeruginosa, and A. baumannii co-cultured with B. bacteriovorus were 65.2%, 37.1%, 44.7%, and 36.8%, respectively. Meanwhile, the established biofilms of E. coli, K. pneumoniae, P. aeruginosa, and A. baumannii were significantly reduced by 83.4%, 81.8%, 83.1%, and 79.9%, respectively. A visual analysis supported by scanning electron microscopy demonstrated the role of B. bacteriovorus in removing the established biofilms This study highlights the potential use of B. bacteriovorus as a biological control agent with the capability to prey on MDR/XDR gram-negative pathogens and eradicate biofilms
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81171614]; Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents [[2012]241]; Planned Science and Technology Project of Wenzhou [Y20140722]; Undergraduate Student Science & Technology Innovation Research Program of Zhejiang Province (Xinmiao Talent Project) [2015R413063]
出版者	NATL INST INFECTIOUS DISEASES
出版地	TOKYO
ISSN	1344-6304
EISSN	1884-2836
卷号	70 期号:5 页码:485-489
DOI	10.7883/yoken.JJID.2016.405
页数	5
WOS类目	Infectious Diseases
WOS研究方向	Infectious Diseases
WOS记录号	WOS:000412715600003
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28367880
SCOPUSEID	2-s2.0-85030101647
通讯作者地址	[Zhou, Tieli]Department of Clinical Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Microbiology (medical);Infectious Diseases
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17688
专题	附属第一医院检验医学院（生命科学学院、生物学实验教学中心）
通讯作者	Zhou, Tieli
作者单位	1.Department of Clinical Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.State Key Laboratory for Diagnosis and Treatment of Infectious Disease,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China; 3.Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,Zhejiang University,Hangzhou,China; 4.School of Laboratory Medicine and Life Science,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院_临床检验诊断学; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院_临床检验诊断学; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Sun, Yao,Ye, Jianzhong,Hou, Yuanbo,et al. Predation Efficacy of Bdellovibrio bacteriovorus on Multidrug-Resistant Clinical Pathogens and Their Corresponding Biofilms[J]. JAPANESE JOURNAL OF INFECTIOUS DISEASES,2017,70(5):485-489.
APA	Sun, Yao, Ye, Jianzhong, Hou, Yuanbo, Chen, Huale, Cao, Jianming, & Zhou, Tieli. (2017). Predation Efficacy of Bdellovibrio bacteriovorus on Multidrug-Resistant Clinical Pathogens and Their Corresponding Biofilms. JAPANESE JOURNAL OF INFECTIOUS DISEASES, 70(5), 485-489.
MLA	Sun, Yao,et al."Predation Efficacy of Bdellovibrio bacteriovorus on Multidrug-Resistant Clinical Pathogens and Their Corresponding Biofilms".JAPANESE JOURNAL OF INFECTIOUS DISEASES 70.5(2017):485-489.