mTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo

doi:10.1016/j.canlet.2013.08.004

科研成果详情

题名	mTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo
作者	Yang, Chunguang 1; Peng, Jianhua1; Jiang, WenJing 1; Zhang, Yue1; Chen, Xiaoyun 1; Wu, Xianmin1; Zhu, Yi 1; Zhang, Huxiang2; Chen, Jianfu1; Wang, Jixian 4; Cho, William C.S.3; Jin, Kunlin1,4
发表日期	2013-12-01
发表期刊	CANCER LETTERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Cancer stem cells Nasopharyngeal carcinoma mTOR signaling Rapamycin
其他关键词	GROWTH-FACTOR RECEPTOR ; BREAST-CANCER ; RIBOSOMAL-PROTEIN ; SIGNALING PATHWAY ; STEM-CELLS ; EXPRESSION ; IDENTIFICATION ; MARKER ; PHOSPHORYLATION ; RESISTANCE
摘要	The mammalian target of rapamycin (mTOR) signaling is a key pathway in the progression of different cancers and in the homeostasis of stem cells. Here, we investigated the link between mTOR signaling and cancer stem cells (CSCs) in nasopharyngeal carcinoma (NPC). We found that human primary NPC expressed embryonic stem cell (ESC) markers: CD133, SOX2 and OCT4 as well as pmTOR and pS6. Primary ESC-positive NPC cells could form secondary NPC in BALB/c nude mice. Rapamycin, an mTOR inhibitor, significantly suppressed ESC-positive NPC cell growth in vitro and tumor formation in vivo. Our findings suggest that mTOR signaling is activated in CSC-like cells and plays an important role in NPC growth. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
资助项目	Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [Y12H160047]; Wenzhou Science and Technology Bureau [H20080025]; Wenzhou Medical College
出版者	ELSEVIER IRELAND LTD
出版地	CLARE
ISSN	0304-3835
EISSN	1872-7980
卷号	341 期号:2 页码:186-194
DOI	10.1016/j.canlet.2013.08.004
页数	9
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000328096300009
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	23933173
SCOPUSEID	2-s2.0-84887178635
通讯作者地址	[Zhang, Yue]Department of Otolaryngology, The First Affiliated Hospital,Wenzhou Medical College,China
Scopus学科分类	Oncology;Cancer Research
TOP期刊	TOP期刊
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17604
专题	附属第一医院
通讯作者	Zhang, Yue
作者单位	1.Department of Otolaryngology,First Affiliated Hospital,Wenzhou Medical University,China; 2.Department of Pathology,First Affiliated Hospital,Wenzhou Medical University,China; 3.Department of Clinical Oncology,Queen Elizabeth Hospital,Hong Kong; 4.Department of Pharmacology and Neuroscience,University of North Texas Health Science Center at Fort Worth,United States
第一作者单位	附属第一医院
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院; 附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yang, Chunguang,Peng, Jianhua,Jiang, WenJing,et al. mTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo[J]. CANCER LETTERS,2013,341(2):186-194.
APA	Yang, Chunguang., Peng, Jianhua., Jiang, WenJing., Zhang, Yue., Chen, Xiaoyun., ... & Jin, Kunlin. (2013). mTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo. CANCER LETTERS, 341(2), 186-194.
MLA	Yang, Chunguang,et al."mTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo".CANCER LETTERS 341.2(2013):186-194.