Panax quinquefolium saponin inhibits endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and attenuates the progression of osteoarthritis in rat

doi:10.1016/j.biopha.2017.10.068

科研成果详情

题名	Panax quinquefolium saponin inhibits endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and attenuates the progression of osteoarthritis in rat
作者	Xie, Jun-Jun 1; Chen, Jian2; Guo, Shi-Kun3; Gu, Yun-Tao 2; Yan, Ying-Zhao 2; Guo, Wei-Jun2; Yao, Cheng-lun 2; Jin, Meng-Yun 1; Xie, Cheng-Long2; Wang, Xiang 4; Wang, Xiang-Yang2; Chen, Long 2
发表日期	2018-01
发表期刊	BIOMEDICINE & PHARMACOTHERAPY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Endoplasmic reticulum stress Apoptosis NF-kappa B Panax quinquefolium saponin Osteoarthritis
其他关键词	NECROSIS FACTOR-ALPHA ; FACTOR-KAPPA-B ; CARDIOMYOCYTE APOPTOSIS ; NITRIC-OXIDE ; DEGENERATION ; MODEL ; MODULATION ; ACTIVATION ; EXPRESSION ; CYTOKINES
摘要	Treatments for osteoarthritis (OA) seek to restore chondrocyte function and inhibit cell apoptosis. Panax quinquefolium saponin (PQS) is the major active ingredient of Radix panacis quinquefolii (American ginseng), and has been demonstrated to exert anti-inflammatory and anti-apoptotic effects in various diseases. However, any potential effect of PQS on the pathological process of OA remains unclear. This work aimed to explore the role of PQS in chondrocytes and to clarify its potential mechanisms. We showed that PQS treatment could protect chondrocytes against endoplasmic reticulum (ER) stress and associated apoptosis induced by interleukin (IL)-1 beta. Also, PQS further attenuated triglyceride (TG)-induced ER stress and associated apoptosis. Moreover, PQS may inhibit the ER stress-activated NF-kappa B pathway and associated inflammatory response in chondrocytes. Finally, PQS abolished rat cartilage degeneration in an in-vivo OA model of the knee joint. Our results indicate that PQS may be a potential novel treatment for OA.
资助项目	Zhejiang province science and technology hall [2017C37125]; Zhejiang Provincial Health Department Foundation of China [2016KYB196, LY15H060008]; Zhejiang Traditional Chinese Medicine Bureau Foundation of China [2016ZA140]; National Nature Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371988]
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
出版地	ISSY-LES-MOULINEAUX
ISSN	0753-3322
EISSN	1950-6007
卷号	97 页码:886-894
DOI	10.1016/j.biopha.2017.10.068
页数	9
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS记录号	WOS:000419041300107
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29136765
SCOPUSEID	2-s2.0-85032792600
通讯作者地址	[Wang, Xiang-Yang]Department of Orthopaedic Surgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类	Pharmacology
TOP期刊	TOP期刊
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17561
专题	药学院（分析测试中心）附属第二医院第二临床医学院、附属第二医院、育英儿童医院眼视光学院（生物医学工程学院）、附属眼视光医院_研究生教学办公室
通讯作者	Wang, Xiang-Yang
作者单位	1.School of Pharmaceutical Sciences,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical University,Wenzhou,325027,China; 2.Department of Orthopaedic Surgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325027,China; 3.Department of Postgraduate Education,Wenzhou Medical University,Wenzhou,325027,China; 4.North Sichuan Medical College,Nanchong,637000,China
第一作者单位	药学院（分析测试中心）
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Xie, Jun-Jun,Chen, Jian,Guo, Shi-Kun,et al. Panax quinquefolium saponin inhibits endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and attenuates the progression of osteoarthritis in rat[J]. BIOMEDICINE & PHARMACOTHERAPY,2018,97:886-894.
APA	Xie, Jun-Jun., Chen, Jian., Guo, Shi-Kun., Gu, Yun-Tao., Yan, Ying-Zhao., ... & Chen, Long. (2018). Panax quinquefolium saponin inhibits endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and attenuates the progression of osteoarthritis in rat. BIOMEDICINE & PHARMACOTHERAPY, 97, 886-894.
MLA	Xie, Jun-Jun,et al."Panax quinquefolium saponin inhibits endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and attenuates the progression of osteoarthritis in rat".BIOMEDICINE & PHARMACOTHERAPY 97(2018):886-894.