Predictive role of serum cholesterol and triglycerides in cervical cancer survival

doi:10.1136/ijgc-2020-001333

科研成果详情

题名	Predictive role of serum cholesterol and triglycerides in cervical cancer survival
作者	Lin, Feng 1,2; Zheng, Ruru2; Yu, Chen 3; Su, Ying2; Yan, Xiaojian2; Qu, Fan 1
发表日期	2021-02
发表期刊	INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 影响因子和分区
语种	英语
原始文献类型	Article
关键词	cervical cancer
摘要	Objective Lipids have been evaluated for their possible role in cancer survival prediction. The aim of the current study was to investigate the prognostic value of lipids on overall survival for stage IB1-IIA2 cervical cancer patients. Methods A retrospective study including cervical cancer patients with early-stage (FIGO 2009 stage IB1-IIA2) disease was conducted from January 2012 to February 2017. Patients with any history of liver disease or other cancers, and patients who took any medications known to influence lipid metabolism, were excluded. We measured various factors in patients' lipid profiles including total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein, and assessed these four parameters together with clinicopathological features to identify the significant prognostic factors for overall survival. Results A total of 583 patients with median age 53 (range 25-82) years were included. Among them, 283 (48.5%) patients were in FIGO stage IB1, 44 patients (7.6%) in stage IB2, 189 (32.4%) patients in stage IIA1, and the remaining 67 (11.5%) patients were in stage IIA2. Using univariable Cox proportional hazard analysis and subsequent multivariable analysis, total cholesterol, triglycerides, and pelvic lymph node status were shown to be independent prognostic factors for overall survival (p<0.05 for all). Furthermore, the results of the Kaplan-Meier survival curves showed that both the high total cholesterol group and the high triglycerides group were associated with worse overall survival (p=0.002 and p=0.001, respectively) Conclusions Our study showed that total triglycerides and total cholesterol may serve as potential predictors for overall survival in patients with cervical cancer. Cervical cancer patients may benefit from treatments after adjusting their triglycerides and total cholesterol levels.
资助项目	Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81803781]; Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [LQ18H280007]
出版者	BMJ PUBLISHING GROUP
出版地	LONDON
ISSN	1048-891X
EISSN	1525-1438
卷号	31 期号:2 页码:171-176
DOI	10.1136/ijgc-2020-001333
页数	6
WOS类目	Oncology ; Obstetrics & Gynecology
WOS研究方向	Oncology ; Obstetrics & Gynecology
WOS记录号	WOS:000616726100003
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	33051246
Scopus记录号	2-s2.0-85093528491
通讯作者地址	[Qu, Fan]Department of Chinese Integrative Medicine,Women's Hospital,Zhejiang University School of Medicine,Hangzhou,China
scopus学科分类	Oncology;Obstetrics and Gynecology
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17518
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_妇科附属第一医院_产科
通讯作者	Qu, Fan
作者单位	1.Department of Chinese Integrative Medicine,Women's Hospital,Zhejiang University School of Medicine,Hangzhou,China; 2.Department of Gynecology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Obstetrics,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院
推荐引用方式 GB/T 7714	Lin, Feng,Zheng, Ruru,Yu, Chen,et al. Predictive role of serum cholesterol and triglycerides in cervical cancer survival[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2021,31(2):171-176.
APA	Lin, Feng, Zheng, Ruru, Yu, Chen, Su, Ying, Yan, Xiaojian, & Qu, Fan. (2021). Predictive role of serum cholesterol and triglycerides in cervical cancer survival. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 31(2), 171-176.
MLA	Lin, Feng,et al."Predictive role of serum cholesterol and triglycerides in cervical cancer survival".INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 31.2(2021):171-176.