科研成果详情

题名Reversing inflammatory microenvironment by a single intra-articular injection of multi-stimulus responsive lipogel to relieve rheumatoid arthritis and promote joint repair
作者
发表日期2023-06
发表期刊Materials Today Bio   影响因子和分区
语种英语
原始文献类型Journal article (JA) ; Article
关键词Cartilage Controlled drug delivery Diseases Enzymatic hydrolysis Infrared devices Joints (anatomy) Macrophages Oxygen Sols Targeted drug delivery Anti-inflammatories Lipogels Macrophage polarization matrix Metalloproteinases Methotrexate Microenvironments Reactive oxygen species Rheumatoid arthritis Stimuli-responsive Drug delivery Lipogel
其他关键词PATHOGENESIS ; AGENT
摘要Rheumatoid arthritis (RA) is a common chronic disease dominated by inflammatory synovitis, which is characterized with hyperplastic synovium, up-regulated matrix metalloproteinase (MMP) expression, hypoxic joint cavity and excessive reactive oxygen species (ROS) accumulation. Such local adverse microenvironment in RA joints further exacerbates the infiltration of synovial inflammatory cells, especially M1-type macrophages. Regulating intra-articular pathological conditions, eliminating excess M1 macrophages or converting them to an anti-inflammatory M2 phenotype may break the vicious progression circle. Herein, we develop a multi-stimulus responsive lipogel as effective platform to relieve RA symptoms and promote articular cartilage recovery via reversing its inflammatory microenvironment. The injectable lipogel is fabricated by loading polydopamine nanoparticles and methotrexate into a thermosensitive gel, and intra-articularly injected to form the therapeutic depot (PDA/MTX@TSG) in situ. The gel degrades slowly under esterase hydrolysis, and maintains sustained drug release in physiological conditions. Meanwhile, it can 1) induce a reversible gel-sol phase transition upon mild photothermal treatment (external NIR light control), and 2) specifically respond to MMP-rich RA microenvironment (internal enzymatic hydrolysis effect). Such stimulus-responsive system can deliver therapeutic components in a controllable manner, and significantly reverse adverse inflammatory microenvironment of RA joints through ROS eliminating, hypoxia alleviating, and M1-M2 macrophage polarization effects. Animal experiments indicate that observable RA relief and joint repair are realized after a single lipogel injection combined with NIR irradiation. Our study highlights the importance of altering local RA microenvironment via anti-inflammatory macrophage polarization, and therefore presents a potent therapeutic strategy for RA treatment in clinical intervention. © 2023 The Authors
资助项目Jiangxi Province Applied Research Cultivation Program[20212BAG70009];National Natural Science Foundation of China[31960207];Jiangxi Provincial Health and Family Planning Commission[20208033];Jiangxi Provincial Department of Science and Technology[S2021YYYJPYG0164];Science Fund for Distinguished Young Scholars of Jiangxi Province[20224ACB214005,82260426];
出版者Elsevier B.V.
ISSN2590-0064
EISSN2590-0064
卷号20
DOI10.1016/j.mtbio.2023.100622
页数11
WOS类目Engineering, Biomedical ; Materials Science, Biomaterials
WOS研究方向Engineering ; Materials Science
WOS记录号WOS:000975530700001
收录类别EI ; PUBMED ; SCIE ; SCOPUS
在线发表日期2023-04
EI入藏号20231413854255
EI主题词Polarization
EI分类号461.2 Biological Materials and Tissue Engineering ; 461.3 Biomechanics, Bionics and Biomimetics ; 461.9.1 Immunology ; 801.2 Biochemistry ; 802.2 Chemical Reactions ; 804 Chemical Products Generally ; 804.1 Organic Compounds
URL查看原文
PubMed ID37056918
SCOPUSEID2-s2.0-85151495067
通讯作者地址[Ai, Fanrong]School of Advanced Manufacturing,Nanchang University,Jiangxi,Nanchang,330031,China ; [Li, Zhenglin]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,325035,China ; [Ning, Yunxuan]The Second Affiliated Hospital of Nanchang University,Jiangxi,Nanchang,330000,China
Scopus学科分类Biotechnology;Bioengineering;Biomaterials;Biomedical Engineering;Molecular Biology;Cell Biology
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/174992
专题药学院(分析测试中心)
其他_附属平阳医院(平阳县人民医院)
通讯作者Ning, Yunxuan; Li, Zhenglin; Ai, Fanrong
作者单位
1.The Second Affiliated Hospital of Nanchang University,Jiangxi,Nanchang,330000,China;
2.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,325035,China;
3.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health,Wenzhou,Zhejiang,325000,China;
4.Pingyang Hospital Affiliated to Wenzhou Medical University,Wenzhou,Zhejiang,325400,China;
5.Department of Orthopaedics,The Second People's Hospital of Jingdezhen,Jiangxi,Jingdezhen,333099,China;
6.School of Advanced Manufacturing,Nanchang University,Jiangxi,Nanchang,330031,China
通讯作者单位药学院(分析测试中心)
推荐引用方式
GB/T 7714
Tao, Jun,Yang, Peng,Gao, Mingying,et al. Reversing inflammatory microenvironment by a single intra-articular injection of multi-stimulus responsive lipogel to relieve rheumatoid arthritis and promote joint repair[J]. Materials Today Bio,2023,20.
APA Tao, Jun., Yang, Peng., Gao, Mingying., Zhang, Fan., Wu, Yongzhong., ... & Ai, Fanrong. (2023). Reversing inflammatory microenvironment by a single intra-articular injection of multi-stimulus responsive lipogel to relieve rheumatoid arthritis and promote joint repair. Materials Today Bio, 20.
MLA Tao, Jun,et al."Reversing inflammatory microenvironment by a single intra-articular injection of multi-stimulus responsive lipogel to relieve rheumatoid arthritis and promote joint repair".Materials Today Bio 20(2023).

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