Icariin-Mediated miR-875-5p Inhibits Autophagy and Epithelial-Mesenchymal Transition by Regulation of MDM4 in Cervical Cancer

doi:10.1166/jbn.2022.3472

科研成果详情

题名	Icariin-Mediated miR-875-5p Inhibits Autophagy and Epithelial-Mesenchymal Transition by Regulation of MDM4 in Cervical Cancer
作者	Duan, Ping 1,2; Cheng, Jing2,3; Mao, Ruotong 2,3; Wang, Ruina 2,3; Jin, Yueqi 2,3; Li, Chunyang4
发表日期	2022-12
发表期刊	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Cervical Cancer Icariin Autophagy MiR-875-5p MDM4
其他关键词	NEOADJUVANT CHEMOTHERAPY ; INVASION ; CELLS
摘要	MicroRNAs, one type of non-coding RNA, and Icariin have attracted tremendous attention concerning various diseases, especially cancers. Also, the function of Icariin on malignant behaviors by targeting miR-875-5p/MDM4 axis in cervical cancer remains unknown. MiR-875-5p analogs combined with MDM4 or Icariin were used to explore autophagy and epithelial-mesenchymal transition in cancer cells. Xenograft mice were highlighted to elucidate the influences of Icariin and miR-875-5p in vivo. As a result, miR-875-5p was cut down in cervical cancer cells, which promoted malignant phenotype, autophagy, and limited apoptosis in cervical cancer cells. Contrarily, miR-87-5p overexpression had a contrary IP: 2038 10920 On: Thu 30 Mar 2023 124955 performance in cervical cancer cells. miR-875-5p was validated as a sponge of MDM4. Enhanced expression of MDM4 Copyright: American Scientific Publshers weakened the performance of miR-875-5p mimic on autophagand epithelial-mesenchymal transition. Moreover, Icariin Delivered by Ingenta reversed the stimulative action of the inhibitor on autophagy and xenograft tumor growth. Generally, These findings imply that Icariin could be identified as a curative avenue for cervical cancer via miR-875-5p/MDM4 axis.
资助项目	Basic public welfare research plan of Zhejiang Province [LGF22H160053]; Health Commission of Zhejiang Province [2022KY897]
出版者	AMER SCIENTIFIC PUBLISHERS
ISSN	1550-7033
EISSN	1550-7041
卷号	18 期号:12 页码:2708-2720
DOI	10.1166/jbn.2022.3472
页数	13
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:000965314700001
收录类别	SCIE
通讯作者地址	[Li, Chunyang]Wenzhou Med Univ, Sch Basic Sci, Dept Biochem, Wenzhou 325000, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/174882
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院检验医学院（生命科学学院、生物学实验教学中心）_生物化学与分子生物学系
通讯作者	Li, Chunyang
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325027, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 2, Reprod Hlth Ctr, Dept Obstet & Gynecol, Wenzhou 325027, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Sch Basic Sci, Dept Biochem, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	温州医科大学
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Duan, Ping,Cheng, Jing,Mao, Ruotong,et al. Icariin-Mediated miR-875-5p Inhibits Autophagy and Epithelial-Mesenchymal Transition by Regulation of MDM4 in Cervical Cancer[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2022,18(12):2708-2720.
APA	Duan, Ping, Cheng, Jing, Mao, Ruotong, Wang, Ruina, Jin, Yueqi, & Li, Chunyang. (2022). Icariin-Mediated miR-875-5p Inhibits Autophagy and Epithelial-Mesenchymal Transition by Regulation of MDM4 in Cervical Cancer. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 18(12), 2708-2720.
MLA	Duan, Ping,et al."Icariin-Mediated miR-875-5p Inhibits Autophagy and Epithelial-Mesenchymal Transition by Regulation of MDM4 in Cervical Cancer".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 18.12(2022):2708-2720.