科研成果详情

题名Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction
作者
发表日期2023-03-01
发表期刊FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY   影响因子和分区
语种英语
原始文献类型Article
关键词diabetic wound miR-132 exosomes macrophages polarization inflammation
其他关键词NF-KAPPA-B ; MICRORNA-132 ; ANGIOGENESIS
摘要

The tissue reconstruction of diabetic wounds mainly depends on the proliferation and remodelling of cutaneous cells around wounds and the transplantation of random skin flaps, however, the proliferation of cells or survival of skin flaps are difficult due to the severe inflammation and other problems caused by diabetes. The stem cell-derived exosomes loaded with miRNA can be an effective therapeutic strategy for promoting diabetic wound healing. Therefore, in this study, the engineered exosomes derived from miR-132-overexpressing adipose stem cells (miR-132-exo) was obtained for promoting the healing of diabetic wounds and skin flaps. In vitro, the miR-132-exo promoted the proliferation and migration of human umbilical vein endothelial cells (HUVECs). In vivo, streptozotocin (STZ) induced diabetic mice were used to create full-thickness skin wounds and random skin flaps to further investigate the healing effect of miR-132-exo. The results showed miR-132-exo evidently enhanced the survival of skin flaps and promote diabetic wound healing, through reducing local inflammation, promoting angiogenesis and stimulating M2-macrophages polarization mediated by NF-kappa B signaling pathway. These novel findings demonstrated that engineered miR-132-exo can be a potent therapeutic for treating diabetic wounds and inflammatory-related disease.

资助项目Zhejiang Provincial Natural Science Foundation of China [Y19H060034] ; Medical Health Science and Technology Project of Zhejiang Province [2020KY183] ; National Undergraduate Training Programs for Innovation and Entrepreneurship [202110343034]
出版者FRONTIERS MEDIA SA
ISSN2296-4185
EISSN2296-4185
卷号11
DOI10.3389/fbioe.2023.1129538
页数18
WOS类目Biotechnology & Applied Microbiology ; Multidisciplinary Sciences
WOS研究方向Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS记录号WOS:000949382900001
收录类别SCIE ; EI ; PUBMED ; SCOPUS
EI入藏号20231213751600
EI主题词Polarization ; Polarization
EI分类号461.1 Biomedical Engineering ; 461.1 Biomedical Engineering ; 461.2 Biological Materials and Tissue Engineering ; 461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 461.9 Biology ; 461.9.1 Immunology ; 461.9.1 Immunology
URL查看原文
PubMed ID36937759
SCOPUSEID2-s2.0-85150274158
ESI高被引论文2024-01 ; 2024-03 ; 2024-05 ; 2024-07
通讯作者地址[Mao, Cong]Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China ; [Feng, Yongzeng]Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类Biotechnology;Bioengineering;Histology;Biomedical Engineering
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/174620
专题第二临床医学院、附属第二医院、育英儿童医院
附属第二医院_骨科重点学科实验室
通讯作者Mao, Cong; Feng, Yongzeng
作者单位
1.Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China;
2.Zhejiang Provincial Key Laboratory of Orthopaedics,Wenzhou Medical University,Wenzhou,China
第一作者单位第二临床医学院,附属第二医院、育英儿童医院;  附属第二医院;  温州医科大学
通讯作者单位第二临床医学院,附属第二医院、育英儿童医院;  附属第二医院
第一作者的第一单位第二临床医学院,附属第二医院、育英儿童医院
推荐引用方式
GB/T 7714
Ge, Lifeng,Wang, Kangyan,Lin, Hang,et al. Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2023,11.
APA Ge, Lifeng., Wang, Kangyan., Lin, Hang., Tao, Endong., Xia, Weijie., ... & Feng, Yongzeng. (2023). Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 11.
MLA Ge, Lifeng,et al."Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 11(2023).

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