Type IV collagen-derived angiogenesis inhibitor: canstatin low expressing in brain-invasive meningiomas using liquid chromatography-mass spectrometry (LC-MS/MS)

doi:10.1007/s11060-023-04256-z

科研成果详情

题名	Type IV collagen-derived angiogenesis inhibitor: canstatin low expressing in brain-invasive meningiomas using liquid chromatography-mass spectrometry (LC-MS/MS)
作者	Pei, Jian 1; Li, Pei 2; Gao, Yun H.1; Tian, Bao G.1; Wang, Da Y.1; Zheng, Yu 1; Liu, Li Y.3; Zhang, Zhi Y.3; Huang, Si S.4; Wen, Min 5; Xu, Xiang 1; Xia, Lei6
发表日期	2023-01
发表期刊	JOURNAL OF NEURO-ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Meningioma Brain invasion Angiogenesis inhibitor Canstatin LC-MS MS
其他关键词	CENTRAL-NERVOUS-SYSTEM ; HEALTH-ORGANIZATION CLASSIFICATION ; ATYPICAL CRANIAL MENINGIOMAS ; ADJUVANT RADIATION ; MANAGEMENT ; PREDICTORS ; TUMORS
摘要	PurposeBrain invasion in meningiomas is considered an indicator of more aggressive behavior and worse prognosis. But the precise definition and the prognostic role of brain invasion remains unsolved duo to lacking a standardized workflow of surgical sampling and the histopathological detection. Searching for molecular biomarker expression correlating with brain invasion, could contribute to establish a molecular pathological diagnosis without problems of subjective interobserver variation and deeply understand the mechanism of brain invasion and develop innovative therapeutic strategies.MethodsWe utilized liquid chromatography tandem mass spectrometry to quantify protein abundances between non-invasive meningiomas (n = 21) and brain-invasive meningiomas (n = 21) spanning World Health Organization grades I and III. After proteomic discrepancies were analyzed, the 14 most up-regulated or down-regulated proteins were recorded. Immunohistochemical staining for glial fibrillary acidic protein and most likely brain invasion-related proteins was performed in both groups.ResultsA total of 6498 unique proteins were identified in non-invasive and brain-invasive meningiomas. Canstatin expression in the non-invasive group was 2.1-fold that of the brain-invasive group. The immunohistochemical staining showed canstatin expressed in both groups, and the non-invasive group showed stronger staining for canstatin in the tumor mass (p = 0.0132) than the brain-invasive group, which showed moderate intensity.ConclusionThis study demonstrated the low expression of canstatin in meningiomas with brain invasion, a finding that provide a basis for understanding the mechanism of brain invasion of meningiomas and may contribute to establish molecular pathological diagnosis and identify novel therapeutic targets for personalized care.
资助项目	Hebei Provincial Department of Science and Technology [16397747D]; Medicine and Health Science and Technology Plan Projects in Zhejiang Province [2022KY201]
出版者	SPRINGER
ISSN	0167-594X
EISSN	1573-7373
卷号	161 期号:2 页码:415-423
DOI	10.1007/s11060-023-04256-z
页数	9
WOS类目	Oncology ; Clinical Neurology
WOS研究方向	Oncology ; Neurosciences & Neurology
WOS记录号	WOS:000936932700001
收录类别	SCIE ; SCOPUS ; PUBMED
在线发表日期	2023-02
URL	查看原文
Pubmed记录号	36811765
Scopus记录号	2-s2.0-85148512795
通讯作者地址	[Xu, Xiang]Department of Neurosurgery,Tangshan Gongren Hospital,Tangshan,063000,China ; [Xia, Lei]Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
scopus学科分类	Oncology;Neurology;Neurology (clinical);Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/174595
专题	基础医学院（机能实验教学中心）_病理学与病理生理学系附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_老化与神经疾病重点实验室
通讯作者	Xu, Xiang; Xia, Lei
作者单位	1.Department of Neurosurgery,Tangshan Gongren Hospital,Tangshan,063000,China; 2.Department of Neurology,Tangshan Gongren Hospital,Tangshan,063000,China; 3.Department of pathology,Tangshan Gongren Hospital,Tangshan,063000,China; 4.Department of pathology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 5.Department of Neurosurgery,School of Medicine,Guangzhou First People’s Hospital,South China University of Technology,Guangzhou,510000,China; 6.Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Pei, Jian,Li, Pei,Gao, Yun H.,et al. Type IV collagen-derived angiogenesis inhibitor: canstatin low expressing in brain-invasive meningiomas using liquid chromatography-mass spectrometry (LC-MS/MS)[J]. JOURNAL OF NEURO-ONCOLOGY,2023,161(2):415-423.
APA	Pei, Jian., Li, Pei., Gao, Yun H.., Tian, Bao G.., Wang, Da Y.., ... & Xia, Lei. (2023). Type IV collagen-derived angiogenesis inhibitor: canstatin low expressing in brain-invasive meningiomas using liquid chromatography-mass spectrometry (LC-MS/MS). JOURNAL OF NEURO-ONCOLOGY, 161(2), 415-423.
MLA	Pei, Jian,et al."Type IV collagen-derived angiogenesis inhibitor: canstatin low expressing in brain-invasive meningiomas using liquid chromatography-mass spectrometry (LC-MS/MS)".JOURNAL OF NEURO-ONCOLOGY 161.2(2023):415-423.