Efficacy and safety of different radiotherapy doses in neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: A retrospective study

doi:10.3389/fonc.2023.1119323

科研成果详情

题名	Efficacy and safety of different radiotherapy doses in neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: A retrospective study
作者	Xu, Yuyan 1; Zou, Haizhou 2; Shao, Zhenyong1; Zhang, Xuebang1; Ren, XiaoLin1; He, Huijuan 3; Zhang, Dahai 4; Du, Dexi 5; Zou, Changlin 1
发表日期	2023-02-21
发表期刊	FRONTIERS IN ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	locally advanced rectal cancer radiotherapy dose intensity-modulated radiation therapy neoadjuvant chemoradiotherapy adverse reactions
其他关键词	TOTAL MESORECTAL EXCISION ; PHASE-III TRIAL ; PREOPERATIVE CHEMORADIOTHERAPY ; RANDOMIZED-TRIAL ; ADJUVANT CHEMOTHERAPY ; TUMOR RESPONSE ; OPEN-LABEL ; FOLLOW-UP ; CHEMORADIATION ; OXALIPLATIN
摘要	BackgroundThis study aims to compare the efficacy and safety of neoadjuvant chemoradiotherapy (nCRT) with different radiotherapy doses (45Gy and 50.4Gy) in patients with locally advanced rectal cancer (LARC). MethodsHerein, 120 patients with LARC were retrospectively enrolled between January 2016 and June 2021. All patients underwent two courses of induction chemotherapy (XELOX), chemoradiotherapy, and total mesorectum excision (TME). A total of 72 patients received a radiotherapy dose of 50.4 Gy, while 48 patients received a dose of 45 Gy. Surgery was then performed within 5-12 weeks following nCRT. ResultsThere was no statistically significant difference between the baseline characteristics of the two groups. The rate of good pathological response in the 50.4Gy group was 59.72% (43/72), while in the 45Gy group achieved 64.58% (31/48) (P>0.05). The disease control rate (DCR) in the 50.4Gy group was 88.89% (64/72), compared to 89.58% (43/48) in the 45Gy group (P>0.05). The incidence of adverse reactions for radioactive proctitis, myelosuppression, and intestinal obstruction or perforation differed significantly between the two groups (P<0.05). The anal retention rate in the 50.4Gy group was significantly higher in contrast to the 45Gy group (P<0.05). ConclusionsPatients receiving a radiotherapy dose of 50.4Gy have a better anal retention rate but also a higher incidence of adverse events such as radioactive proctitis, myelosuppression, and intestinal obstruction or perforation, and a comparable prognosis to patients treated with a radiotherapy dose of 45Gy.
资助项目	Wenzhou Science Technology Bureau [Y20180220]; Zhejiang Medical Association [2022ZYC-Z27]
出版者	FRONTIERS MEDIA SA
ISSN	2234-943X
卷号	13
DOI	10.3389/fonc.2023.1119323
页数	13
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000943601100001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	36895482
SCOPUSEID	2-s2.0-85149694029
通讯作者地址	[Zou, Changlin]Department of Radiotherapy,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/174589
专题	附属第一医院_放化疗科
通讯作者	Zou, Changlin
作者单位	1.Department of Radiotherapy,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Oncology,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou,China; 3.Department of Radiotherapy,Quzhou People’s Hospital,Quzhou,China; 4.Department of Radiotherapy,Dongyang People’s Hospital,Jinhua,China; 5.Department of Radiotherapy Oncology,Lishui Central Hospital,Lishui,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xu, Yuyan,Zou, Haizhou,Shao, Zhenyong,et al. Efficacy and safety of different radiotherapy doses in neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: A retrospective study[J]. FRONTIERS IN ONCOLOGY,2023,13.
APA	Xu, Yuyan., Zou, Haizhou., Shao, Zhenyong., Zhang, Xuebang., Ren, XiaoLin., ... & Zou, Changlin. (2023). Efficacy and safety of different radiotherapy doses in neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: A retrospective study. FRONTIERS IN ONCOLOGY, 13.
MLA	Xu, Yuyan,et al."Efficacy and safety of different radiotherapy doses in neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: A retrospective study".FRONTIERS IN ONCOLOGY 13(2023).