Hybrid Hydrogel Loaded with Chlorhexidine⊂β-CD-MSN Composites as Wound Dressing

doi:10.2147/IJN.S401705

科研成果详情

题名	Hybrid Hydrogel Loaded with Chlorhexidine⊂β-CD-MSN Composites as Wound Dressing
作者	Lin, Jian 1; Shi, Tianpeng 2; Wang, Yi 1; He, Zhiqi1; Mu, Zhixiang 1; Cai, Xiaojun 1; Deng, Hui1; Shen, Jianliang3,4,5; Liu, Fen 6
发表日期	2023
发表期刊	International journal of nanomedicine 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	antibacterial property cyclodextrin mesoporous silica pH-responsive wound healing
其他关键词	MESOPOROUS SILICA NANOPARTICLES ; CONTROLLED-RELEASE ; BETA-CYCLODEXTRIN ; ANTIBACTERIAL ; DELIVERY ; NANOCONTAINERS ; ADHESIVE ; DEVICE
摘要	Much attention has been paid to sustained drug release and anti-infection in wound management. Hydrogels, which are biocompatible materials, are promising tools for controlled drug release and infective protection during wound healing. However, hydrogels also demonstrate limitations in the highly efficient treatment of wounds because of the diffusion rate. In this work, we explored pH-sensitive hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties., We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA). The release mechanism of CHX was explored using UV-vis spectra after intermittent diffusion of CHX. The hybrid hydrogels were characterized, and the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments were investigated., Except for dual protection from both hydrogels, MSN in the HA improved the drug loading efficiency to promote the local drug concentration. It showed that complicated CHX-loaded MSN releases CHX more gradually and over a longer duration than CHX-loaded MSNs. This demonstrated a 12-day CHX release time and antibacterial activity, primarily attributable to the capacity of β-CD to form an inclusion complex with CHX. Meanwhile, in vivo experiments revealed that the hydrogels safely promote skin wound healing and enhance therapeutic efficacy., We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties. The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
资助项目	Zhejiang Provincial Science and Technology Project for Public Welfare [LGF20H140003, LGF21H140006, LTGY23H140008]; Public Welfare Science and Technology Plan of Wenzhou [Y20190101, Y20170242, Y20210115]; Zhejiang Provincial Medical and Health Science and Technology Plan [2019KY444]
出版者	DOVE MEDICAL PRESS LTD
ISSN	1176-9114
EISSN	1178-2013
卷号	18 页码:1725-1740
DOI	10.2147/IJN.S401705
页数	16
WOS类目	Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS研究方向	Science & Technology - Other Topics ; Pharmacology & Pharmacy
WOS记录号	WOS:000964047700001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	37025923
SCOPUSEID	2-s2.0-85151827242
通讯作者地址	[Deng, Hui]School & Hospital of Stomatology,Wenzhou Medical University,Wenzhou,China ; [Liu, Fen]Department of Histology and Embryology,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Biophysics;Bioengineering;Biomaterials;Pharmaceutical Science;Drug Discovery;Organic Chemistry
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/174277
专题	口腔医学院、附属口腔医院眼视光学院（生物医学工程学院）、附属眼视光医院基础医学院（机能实验教学中心）_形态学系_组织胚胎学
通讯作者	Deng, Hui; Liu, Fen
作者单位	1.School & Hospital of Stomatology,Wenzhou Medical University,Wenzhou,China; 2.Department of Stomatology,PLA Strategic Support Force Medical Center,Beijing,China; 3.State Key Laboratory of Ophthalmology,Optometry and Vision Science,School of Ophthalmology & Optometry,School of Biomedical Engineering,Wenzhou Medical University,Wenzhou,China; 4.Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,China; 5.Department of Regenerative Medicine,Vision,and Brain Health,Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision,and Brain Health),Wenzhou,China; 6.Department of Histology and Embryology,Wenzhou Medical University,Wenzhou,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学; 组织胚胎学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Lin, Jian,Shi, Tianpeng,Wang, Yi,et al. Hybrid Hydrogel Loaded with Chlorhexidine⊂β-CD-MSN Composites as Wound Dressing[J]. International journal of nanomedicine,2023,18:1725-1740.
APA	Lin, Jian., Shi, Tianpeng., Wang, Yi., He, Zhiqi., Mu, Zhixiang., ... & Liu, Fen. (2023). Hybrid Hydrogel Loaded with Chlorhexidine⊂β-CD-MSN Composites as Wound Dressing. International journal of nanomedicine, 18, 1725-1740.
MLA	Lin, Jian,et al."Hybrid Hydrogel Loaded with Chlorhexidine⊂β-CD-MSN Composites as Wound Dressing".International journal of nanomedicine 18(2023):1725-1740.