Association between Pregestational Vaginal Dysbiosis and Incident Hypertensive Disorders of Pregnancy Risk: a Nested Case-Control Study

doi:10.1128/msphere.00096-23

科研成果详情

题名	Association between Pregestational Vaginal Dysbiosis and Incident Hypertensive Disorders of Pregnancy Risk: a Nested Case-Control Study
作者	Li, Xiao 1,2; Tian, Zhaomei 1,2; Cui, Ran 1,2; Lv, Jiale 1,2; Yang, Xin 1,2,3; Qin, Lang 1,2; Liu, Zheng 1,2; Zhang, Changlong 1,2; Jin, Congcong1,2,4; Xu, Yanqi 1,2,5; Chen, Zi-Jiang 1,2,6,7,8; Zhao, Han 1,2,9; Zhao, Shigang 1,2
发表日期	2023-06-22
发表期刊	mSphere 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	16S ribosomal RNA Lactobacillus crispatus hypertensive disorders of pregnancy microbiome vagina
其他关键词	DIETARY AMINO-ACIDS ; GARDNERELLA-VAGINALIS ; COMPLEMENT ACTIVATION ; PREECLAMPSIA ; BACTERIA ; POPULATION ; MICROBIOTA ; INFECTION ; ADHERENCE ; INVASION
摘要	A balanced vaginal microbiome dominated by Lactobacillus can help promote women's reproductive health, with Lactobacillus crispatus showing the most beneficial effect. However, the potential role of vaginal microbiomes in hypertensive disorders of pregnancy (HDP) development is not thoroughly explored. In this nested case-control study based on an assisted reproductive technology follow-up cohort, we prospectively assessed the association between pregestational vaginal microbiomes with HDP by collecting vaginal swabs from 75 HDP cases (HDP group) and 150 controls (NP group) and using 16S amplicon sequencing for bacterial identification. The vaginal microbial composition of the HDP group significantly differed from that of the NP group. The abundance of L. crispatus was significantly lower, and the abundances of Gardnerella vaginalis was significantly higher, in the HDP group than in the NP group. Of note, L. crispatus-dominated vaginal community state type was associated with a decreased risk for HDP (odds ratio = 0.436; 95% confidence interval, 0.229 to 0.831) compared with others. Additionally, network analysis revealed different bacterial interactions with 61 and 57 exclusive edges in the NP and HDP groups, respectively. Compared with the HDP group, the NP group showed a higher weighted degree and closeness centrality. Several taxa, including G. vaginalis, L. iners, and bacterial vaginosis-associated bacteria (Prevotella, Megasphaera, Finegoldia, and Porphyromonas), were identified as "drivers" for network rewiring. Notable alterations of predicted pathways involved in amino acid, cofactor, and vitamin metabolism; membrane transport; and bacterial toxins were observed in the HDP group. IMPORTANCE The etiology of HDP remains unclear to date. Effective methods for the individualized prediction and prevention are lacking. Pregestational vaginal dysbiosis precedes the diagnosis of HDP, providing a novel perspective on the etiology of HDP. Early pregnancy is the critical period of placental development, and abnormal placentation initiates HDP development. Thus, disease prevention should be considered before pregnancy. Vaginal microbiome characterization and probiotic interventions before pregnancy are preferred because of their safety and potential for early prevention. This study is the first to prospectively assess associations between pregestational vaginal microbiome and HDP. L. crispatus-dominated vaginal community state type is linked to a reduced risk for HDP. These findings suggest that vaginal microbiome characterization may help identify individuals at high risk for HDP and offer potential targets for the development of novel pregestational intervention methods
资助项目	National Key Research and Development Program of China [2021YFC2700701, 2021YFC2700400]; Basic Science Center Program of Natural Science Foundation of China [31988101]; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences [2020RU001]; Shandong Provincial Key Research and Development Program [2020ZLYS02]; innovative research team of high-level local universities in Shanghai [SHSMU-ZLCX20210200]; CAMS Innovation Fund for Medical Sciences [2021-I2M-5-001]; National Natural Science Foundation of China [82192874, 31871509, 82071606]; Taishan Scholars Program of Shandong Province [ts20190988]; Fundamental Research Funds of Shandong University
出版者	AMER SOC MICROBIOLOGY
ISSN	2379-5042
EISSN	2379-5042
卷号	8 期号:3
DOI	10.1128/msphere.00096-23
页数	13
WOS类目	Microbiology
WOS研究方向	Microbiology
WOS记录号	WOS:000963263000001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-04
URL	查看原文
PubMed ID	37017519
SCOPUSEID	2-s2.0-85164041232
通讯作者地址	[Zhao, Shigang]Center for Reproductive Medicine,Shandong University,Shandong,Jinan,China
Scopus学科分类	Microbiology;Molecular Biology
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/174252
专题	附属第一医院_生殖医学中心
通讯作者	Zhao, Shigang
作者单位	1.Center for Reproductive Medicine,Shandong University,Shandong,Jinan,China; 2.Key Laboratory of Reproductive Endocrinology of Ministry of Education,Shandong University,Shandong,Jinan,China; 3.Reproductive Medicine Center of Zibo Maternal and Child Health Care Hospital,Shandong,Zibo,China; 4.Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 5.Linyi People's Hospital,Shandong,Linyi,China; 6.Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics,Shanghai,China; 7.Center for Reproductive Medicine,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China; 8.Research Unit of Gametogenesis and Health of ART-Offspring,Chinese Academy of Medical Sciences,China; 9.Shandong Key Laboratory of Reproductive Medicine,Shandong First Medical University,Shandong,Jinan,China
推荐引用方式 GB/T 7714	Li, Xiao,Tian, Zhaomei,Cui, Ran,et al. Association between Pregestational Vaginal Dysbiosis and Incident Hypertensive Disorders of Pregnancy Risk: a Nested Case-Control Study[J]. mSphere,2023,8(3).
APA	Li, Xiao., Tian, Zhaomei., Cui, Ran., Lv, Jiale., Yang, Xin., ... & Zhao, Shigang. (2023). Association between Pregestational Vaginal Dysbiosis and Incident Hypertensive Disorders of Pregnancy Risk: a Nested Case-Control Study. mSphere, 8(3).
MLA	Li, Xiao,et al."Association between Pregestational Vaginal Dysbiosis and Incident Hypertensive Disorders of Pregnancy Risk: a Nested Case-Control Study".mSphere 8.3(2023).