Drug substitution and adjuvant therapy in patients with genetics related infertility: A review

doi:10.5582/ddt.2022.01096

科研成果详情

题名	Drug substitution and adjuvant therapy in patients with genetics related infertility: A review
作者	Zhu, Jun 1; Jin, Jiaxi 1; Qi, Qing 2,3,4; Zhou, Qi 5; Zhou, Jing 2,3,4,6; Wang, Ling 2,3,4,6
发表日期	2023-03-30
发表期刊	Drug discoveries & therapeutics 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Genetics adjuvant therapy drug substitution infertility targeted drugs
其他关键词	CONGENITAL ADRENAL-HYPERPLASIA ; VITAMIN-D ; FOLIC-ACID ; ENDOMETRIAL RECEPTIVITY ; PARKINSONS-DISEASE ; SPERM PARAMETERS ; ASSOCIATION ; MTHFR ; POLYMORPHISMS ; WOMEN
摘要	With the in-depth study of the human genome and the increasing popularity of gene sequencing, it has been gradually confirmed that genetics can play a crucial role in infertility. To provide references for clinical treatment, we have focused on genes and drug therapy for genetic infertility. This review recommends adjuvant therapy and drug substitution. Examples of these therapies include antioxidants (such as folic acid, vitamin D, vitamin E, inositol, coenzyme Q10 etc.), metformin, anticoagulants, levothyroxine, dehydroepiandrosterone, glucocorticoids, and gonadotropins etc. Based on the pathogenesis, we provide an overview of the current knowledge, including randomized controlled trials and systematic reviews, and predict potential target genes and signaling pathways, proposing possible future strategies for the use of targeted drugs to treat infertility. Non-coding RNAs are anticipated to become a novel target for the treatment of reproductive illnesses since they have a significant role in controlling the occurrence and development of reproductive diseases.
资助项目	Taizhou Science and Technology Foundation [1902ky154]; Scientific and Technological Innovation Action Plan of the Shanghai Natural Science Fund [20ZR1409100]; Chinese Association of Integration of Traditional and Western Medicine special foundation for Obstetrics and Gynecology-PuZheng Pharmaceutical Foundation [FCK-PZ-08]; project for hospital management of the Shanghai Hospital Association [X2021046]; clinical trial project of the Special Foundation for Healthcare Research of the Shanghai Municipal Health Commission [202150042]; State Administration of Traditional Chinese Medicine for Traditional Chinese Medicine Studio of Huang Suying; project of Shanghai Municipal Health Commission for Traditional Chinese Medicine Studio of Huang Suying [SHGZS-2022247]
出版者	INT RESEARCH & COOPERATION ASSOC BIO & SOCIO-SCIENCES ADVANCEMENT
ISSN	1881-7831
EISSN	1881-784X
卷号	17 期号:2 页码:73-86
DOI	10.5582/ddt.2022.01096
页数	14
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000962859900001
收录类别	PUBMED ; ESCI
在线发表日期	2023-03
URL	查看原文
Pubmed记录号	36990765
通讯作者地址	[Zhou, Jing;Wang, Ling]Fudan Univ, Lab Reprod Immunol, Obstet & Gynecol Hosp, 419 Fangxie Rd, Shanghai 200011, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/174182
专题	其他_附属温岭医院（温岭市第一人民医院）
通讯作者	Zhou, Jing; Wang, Ling
作者单位	1.Wenzhou Med Univ, Affiliated Wenling Hosp, Wenzhou, Zhejiang, Peoples R China; 2.Fudan Univ, Lab Reprod Immunol, Obstet & Gynecol Hosp, Shanghai, Peoples R China; 3.Fudan Univ, Acad Integrat Med, Shanghai, Peoples R China; 4.Shanghai Key Lab Female Reprod Endocrine Related D, Shanghai, Peoples R China; 5.Tradit Chinese Med Hosp Yangpu Dist, Dept Gynecol, Shanghai, Peoples R China; 6.Fudan Univ, Lab Reprod Immunol, Obstet & Gynecol Hosp, 419 Fangxie Rd, Shanghai 200011, Peoples R China
第一作者单位	附属温岭医院（温岭市第一人民医院）
第一作者的第一单位	附属温岭医院（温岭市第一人民医院）
推荐引用方式 GB/T 7714	Zhu, Jun,Jin, Jiaxi,Qi, Qing,et al. Drug substitution and adjuvant therapy in patients with genetics related infertility: A review[J]. Drug discoveries & therapeutics,2023,17(2):73-86.
APA	Zhu, Jun, Jin, Jiaxi, Qi, Qing, Zhou, Qi, Zhou, Jing, & Wang, Ling. (2023). Drug substitution and adjuvant therapy in patients with genetics related infertility: A review. Drug discoveries & therapeutics, 17(2), 73-86.
MLA	Zhu, Jun,et al."Drug substitution and adjuvant therapy in patients with genetics related infertility: A review".Drug discoveries & therapeutics 17.2(2023):73-86.