Discovery of therapeutic targets of quercetin for endometrial carcinoma patients infected with COVID-19 through network pharmacology

doi:10.3389/fonc.2023.1151434

科研成果详情

题名	Discovery of therapeutic targets of quercetin for endometrial carcinoma patients infected with COVID-19 through network pharmacology
作者	Li, Kehan1; Liu, Hejing1; Lin, Yibin1; Gu, Liang2; Xiang, Xinli 1; Zhu, Xueqiong1,2
发表日期	2023-03-08
发表期刊	Frontiers in oncology 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Article
关键词	COVID-19 network pharmacology (NP) quercetin ubiquitination uterine corpus endometrial carcinoma (UCEC)
其他关键词	CANCER-RISK ; EXPRESSION ; CELLS
摘要	Aimed to identify the anti-uterine corpus endometrial carcinoma (UCEC) function and characterize the mechanism of quercetin in the treatment of patients infected with COVID-19 via integrated in silico analysis.}, {AbstractText=The Cancer Genome Atlas and Genotype Tissue Expression databases were applied to obtain differentially expressed genes of UCEC and non-tumor tissue. Several in silico methods such as network pharmacology, functional enrichment analysis, Cox regression analyses, somatic mutation analysis, immune infiltration and molecular docking were used to investigate and analysis the biological targets, functions and mechanisms of anti-UCEC/COVID-19 of quercetin. Multiple methods such as CCK8 assay, Transwell assay and western blotting were performed to test proliferation, migration, and protein level of UCEC (HEC-1 and Ishikawa) cells.}, {AbstractText=Functional analysis disclosed that quercetin against UCEC/COVID-19 mainly by 'biological regulation', 'response to stimulus', and 'regulation of cellular process'. Then, regression analyses indicated that 9 prognostic genes (including ANPEP, OAS1, SCGB1A1, HLA-A, NPPB, FGB, CCL2, TLR4, and SERPINE1) might play important roles in quercetin for treating UCEC/COVID-19. Molecular docking analysis revealed that the protein products of 9 prognostic genes were the important anti-UCEC/COVID-19 biological targets of quercetin. Meanwhile, the proliferation and migration of UCEC cells were inhibited by quercetin. Moreover, after treatment with quercetin, the protein level of ubiquitination-related gene ISG15 was decreased in UCEC cells in vitro.}, {AbstractText=Taken together, this study provides new treatment option for UCEC patients infected with COVID-19. Quercetin may work by reducing the expression of ISG15 and participating in ubiquitination-related pathways
资助项目	Zhejiang Key Laboratory of Traditional Chinese Medicine for Diagnosis and Treatment of Gynecological Cancers [2022-11]
出版者	FRONTIERS MEDIA SA
ISSN	2234-943X
卷号	13
DOI	10.3389/fonc.2023.1151434
页数	15
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000954384900001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	36969077
SCOPUSEID	2-s2.0-85150503882
通讯作者地址	[Zhu, Xueqiong]Center of Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province,Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/174157
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院第一临床医学院（信息与工程学院）、附属第一医院_妇产科学
通讯作者	Zhu, Xueqiong
作者单位	1.Center of Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province,Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of Obstetrics and Gynecology,Taizhou Women and Children’s Hospital of Wenzhou Medical University,Zhejiang,Taizhou,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 妇产科
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 妇产科
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Li, Kehan,Liu, Hejing,Lin, Yibin,et al. Discovery of therapeutic targets of quercetin for endometrial carcinoma patients infected with COVID-19 through network pharmacology[J]. Frontiers in oncology,2023,13.
APA	Li, Kehan, Liu, Hejing, Lin, Yibin, Gu, Liang, Xiang, Xinli, & Zhu, Xueqiong. (2023). Discovery of therapeutic targets of quercetin for endometrial carcinoma patients infected with COVID-19 through network pharmacology. Frontiers in oncology, 13.
MLA	Li, Kehan,et al."Discovery of therapeutic targets of quercetin for endometrial carcinoma patients infected with COVID-19 through network pharmacology".Frontiers in oncology 13(2023).