Engineering Bioactive M2 Macrophage-Polarized Anti-Inflammatory, Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair

doi:10.1002/adfm.202100924

科研成果详情

题名	Engineering Bioactive M2 Macrophage-Polarized Anti-Inflammatory, Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair
作者	Tu, Zhuolong 1,2; Chen, Mi 3; Wang, Min 3; Shao, Zhenxuan 1; Jiang, Xiaoqi 1,2; Wang, Kangyan1; Yao, Zhe1,2; Yang, Shiwei 1; Zhang, Xingxing 2; Gao, Weiyang1; Lin, Cai2; Lei, Bo 3,4; Mao, Cong1
发表日期	2021-07
发表期刊	ADVANCED FUNCTIONAL MATERIALS 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	angiogenesis anti-inflammation activity diabetic wound repair macrophages polarization multifunctional bioactive scaffolds
其他关键词	GRAPHENE OXIDE SCAFFOLDS ; ACTIVATION ; RESPONSES
摘要	Diabetic wound healing still faces great challenges due to the excessive inflammation, easy infection, and impaired angiogenesis in wound beds. The immunoregulation of macrophages polarization toward M2 phenotype that facilitates the transition from inflammation to proliferation phase has been proved to be an effective way to improve diabetic wound healing. Herein, an M2 phenotype-enabled anti-inflammatory, antioxidant, and antibacterial conductive hydrogel scaffolds (GDFE) for producing rapid angiogenesis and diabetic wound repair are reported. The GDFE scaffolds are fabricated facilely through the dynamic crosslinking between polypeptide and polydopamine and graphene oxide. The GDFE scaffolds possess thermosensitivity, self-healing behavior, injectability, broad-spectrum antibacterial activity, antioxidant and anti-inflammatory ability, and electronic conductivity. GDFE effectively activates the polarization of macrophages toward M2 phenotype and significantly promotes the proliferation of dermal fibroblasts, the migration, and in vitro angiogenesis of endothelial cells through paracrine mechanisms. The in vivo results from a full-thickness diabetic wound model demonstrate that GDFE can rapidly promote the diabetic wound repair and skin regeneration, through fast anti-inflammation and angiogenesis and M2 macrophage polarization. This study provides highly efficient strategy for treating diabetic wound repair through designing the M2 polarization-enabled anti-inflammatory, antioxidant, and antibacterial bioactive materials.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51802227, 51872224]; Zhejiang Provincial Basic Public Welfare Research program [LGF18H150008]; Medical Health Science and Technology Project of Zhejiang Province [2019KY464]; Wenzhou Science and Technology Bureau Project [ZY2019003, Y20190123, Y2020236]; Special Support Program for High Level Talents of Shaanxi Province [7122200063]
出版者	WILEY-V C H VERLAG GMBH
出版地	WEINHEIM
ISSN	1616-301X
EISSN	1616-3028
卷号	31 期号:30
DOI	10.1002/adfm.202100924
页数	18
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS记录号	WOS:000654870800001
收录类别	SCIE ; EI ; SCOPUS
EI入藏号	20212210418599
EI主题词	Macrophages
URL	查看原文
SCOPUSEID	2-s2.0-85106535769
ESI热点论文	2023-01
ESI高被引论文	2023-05 ; 2023-01 ; 2023-03 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09
自科自定义期刊分类	T3(A)类
通讯作者地址	[Mao, Cong]Key Laboratory of Orthopedics of Zhejiang Province,Department of Orthopedics,the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325027,China ; [Lin, Cai]Department of Burn,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Lei, Bo]Frontier Institute of Science and Technology,Xi'an Jiaotong University,Xi'an,710000,China
Scopus学科分类	Electronic, Optical and Magnetic Materials;Chemistry (all);Biomaterials;Materials Science (all);Condensed Matter Physics;Electrochemistry
引用统计	被引频次：63[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17406
专题	第二临床医学院、附属第二医院、育英儿童医院附属第一医院_烧伤科
通讯作者	Lin, Cai; Lei, Bo; Mao, Cong
作者单位	1.Key Laboratory of Orthopedics of Zhejiang Province,Department of Orthopedics,the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325027,China; 2.Department of Burn,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Frontier Institute of Science and Technology,Xi'an Jiaotong University,Xi'an,710000,China; 4.National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710000,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Tu, Zhuolong,Chen, Mi,Wang, Min,et al. Engineering Bioactive M2 Macrophage-Polarized Anti-Inflammatory, Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair[J]. ADVANCED FUNCTIONAL MATERIALS,2021,31(30).
APA	Tu, Zhuolong., Chen, Mi., Wang, Min., Shao, Zhenxuan., Jiang, Xiaoqi., ... & Mao, Cong. (2021). Engineering Bioactive M2 Macrophage-Polarized Anti-Inflammatory, Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair. ADVANCED FUNCTIONAL MATERIALS, 31(30).
MLA	Tu, Zhuolong,et al."Engineering Bioactive M2 Macrophage-Polarized Anti-Inflammatory, Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair".ADVANCED FUNCTIONAL MATERIALS 31.30(2021).