Altered Variability and Concordance of Dynamic Resting-State fMRI Indices in Patients With Attention Deficit Hyperactivity Disorder

doi:10.3389/fnins.2021.731596

科研成果详情

题名	Altered Variability and Concordance of Dynamic Resting-State fMRI Indices in Patients With Attention Deficit Hyperactivity Disorder
作者	Lou, Feiling 1; Tao, Jiejie1; Zhou, Ronghui 1; Chen, Shuangli 1; Qian, Andan1; Yang, Chuang2; Zheng, Xiangwu1; Chen, Bicheng 3; Hu, Zhishan 4; Wang, Meihao1
发表日期	2021-09-16
发表期刊	FRONTIERS IN NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	ADHD resting-state fMRI temporal dynamics concordance variability
其他关键词	SPONTANEOUS BRAIN ACTIVITY ; FUNCTIONAL CONNECTIVITY ; DEFICIT/HYPERACTIVITY DISORDER ; NETWORK CENTRALITY ; AMPLITUDE ; CHILDREN ; FLUCTUATIONS
摘要	Objective: Attention deficit hyperactivity disorder (ADHD) is a commonly diagnosed neuropsychiatric disorder in children, which is characterized by inattention, hyperactivity and impulsivity. Using resting-state functional magnetic resonance imaging (R-fMRI), the alterations of static and dynamic characteristics of intrinsic brain activity have been identified in patients with ADHD. Yet, it remains unclear whether the concordance among indices of dynamic R-fMRI is altered in ADHD. Methods: R-fMRI scans obtained from 50 patients with ADHD and 28 healthy controls (HC) were used for the current study. We calculated the regional dynamic changes in brain activity indices using the sliding-window method and compared the differences in variability of these indices between ADHD patients and HCs. Further, the concordance among these dynamic indices was calculated and compared. Finally, the relationship between variability/concordance of these indices and ADHD-relevant clinical test scores was investigated. Results: Patients with ADHD showed decreased variability of dynamic amplitude of low-frequency fluctuation (dALFF) in the left middle frontal gyrus and increased one in right middle occipital gyrus, as compared with the HCs. Besides, ADHD patients showed decreased voxel-wise concordance in the left middle frontal gyrus. Further, lower voxel-wise concordance in ADHD's left middle frontal gyrus was associated with more non-perseverative errors in Wisconsin Card Sorting Test, which reflects worse cognitive control. Conclusion: Our findings suggest that variability and concordance in dynamic brain activity may serve as biomarkers for the diagnosis of ADHD. Further, the decreased voxel-wise concordance is associated with deficit in cognitive control in ADHD patients.
资助项目	Wenzhou Municipal Science and Technology Bureau [Y20180185)]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1662-4548
EISSN	1662-453X
卷号	15 页码:731596
DOI	10.3389/fnins.2021.731596
页数	9
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000702015200001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	34602972
PMC记录号	PMC8481633
SCOPUSEID	2-s2.0-85116250206
通讯作者地址	[Wang, Meihao]Department of Radiology,Hospital of Wenzhou Medical University,Wenzhou,China ; [Hu, Zhishan]State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,Beijing,China
Scopus学科分类	Neuroscience (all)
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17402
专题	第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_放射科附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Hu, Zhishan; Wang, Meihao
作者单位	1.Department of Radiology,Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Psychiatry,Hospital of Wenzhou Medical University,Wenzhou,China; 3.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,Zhejiang Provincial Top Key Discipline in Surgery,Hospital of Wenzhou Medical University,Wenzhou,China; 4.State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,Beijing,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Lou, Feiling,Tao, Jiejie,Zhou, Ronghui,et al. Altered Variability and Concordance of Dynamic Resting-State fMRI Indices in Patients With Attention Deficit Hyperactivity Disorder[J]. FRONTIERS IN NEUROSCIENCE,2021,15:731596.
APA	Lou, Feiling., Tao, Jiejie., Zhou, Ronghui., Chen, Shuangli., Qian, Andan., ... & Wang, Meihao. (2021). Altered Variability and Concordance of Dynamic Resting-State fMRI Indices in Patients With Attention Deficit Hyperactivity Disorder. FRONTIERS IN NEUROSCIENCE, 15, 731596.
MLA	Lou, Feiling,et al."Altered Variability and Concordance of Dynamic Resting-State fMRI Indices in Patients With Attention Deficit Hyperactivity Disorder".FRONTIERS IN NEUROSCIENCE 15(2021):731596.