Synthesis, anti-tumor activity, and structure-activity relationships of curcumol derivatives

doi:10.1080/10286020.2013.857660

科研成果详情

题名	Synthesis, anti-tumor activity, and structure-activity relationships of curcumol derivatives
作者	Guo, Ping1,2; Wang, Yue-Wu 2; Weng, Bi-Xia2; Li, Xiao-Kun2; Yang, Shu-Lin 1; Ye, Fa-Qing2
发表日期	2014-01-02
发表期刊	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	curcumol synthesis derivatives anti-tumor activity structure-activity relationships
其他关键词	CELLS
摘要	Using curcumol that was extracted from the volatile oil of Rhizoma Curcumae as the raw material, its derivatives were synthesized and purified. The structures of these compounds were confirmed by H-1, C-13 NMR, and mass spectral data. The test compounds were evaluated for their in vitro anti-tumor activity against gastric cancer cell lines SGC-7901 and lung carcinoma cell line H460 by methyl thiazolyl tetrazolium chromatometry. Distinct structure-activity relationships of these curcumol derivatives were also revealed for inhibiting cell proliferation. Presence of electron-withdrawing groups or amino could increase the activity significantly, whereas esterification of 8-hydroxy diminished the anti-tumor activity. Many of the tested candidates exhibited higher inhibition efficiency than curcumol, suggesting that structural modifications could enhance its activity effectively.
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	1028-6020
EISSN	1477-2213
卷号	16 期号:1 页码:53-58
DOI	10.1080/10286020.2013.857660
页数	6
WOS类目	Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS记录号	WOS:000329564300007
收录类别	SCIE ; SCOPUS ; 万方 ; IC
URL	查看原文
PubMed ID	24266515
SCOPUSEID	2-s2.0-84892533911
通讯作者地址	[Ye, Fa-Qing]School of Pharmacy,Wenzhou Medical College,China
Scopus学科分类	Analytical Chemistry;Molecular Medicine;Pharmacology;Pharmaceutical Science;Drug Discovery;Complementary and Alternative Medicine;Organic Chemistry
万方分类号	R9(药学)
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17365
专题	药学院（分析测试中心）
通讯作者	Ye, Fa-Qing
作者单位	1.Institute of Chemical Technology,Nanjing University of Science and Technology,China; 2.School of Pharmacy,Wenzhou Medical College,China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Guo, Ping,Wang, Yue-Wu,Weng, Bi-Xia,et al. Synthesis, anti-tumor activity, and structure-activity relationships of curcumol derivatives[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2014,16(1):53-58.
APA	Guo, Ping, Wang, Yue-Wu, Weng, Bi-Xia, Li, Xiao-Kun, Yang, Shu-Lin, & Ye, Fa-Qing. (2014). Synthesis, anti-tumor activity, and structure-activity relationships of curcumol derivatives. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 16(1), 53-58.
MLA	Guo, Ping,et al."Synthesis, anti-tumor activity, and structure-activity relationships of curcumol derivatives".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 16.1(2014):53-58.