Preparation and evaluation of aldehyde starch hemostatic microspheres crosslinked with L-cystine dimethyl ester for ultrarapid rapid hemostasis

doi:10.1002/pat.5995

科研成果详情

题名	Preparation and evaluation of aldehyde starch hemostatic microspheres crosslinked with L-cystine dimethyl ester for ultrarapid rapid hemostasis
作者	Li, Xujian 1,2,3; Chen, Xumin 4; Ji, Zhixiao 1; Pan, Luqi 1; Liu, Yi1,4; Yang, Xiao 1; Shi, Changcan 1,2,3
发表日期	2023-05
发表期刊	POLYMERS FOR ADVANCED TECHNOLOGIES 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	aldehyde starch biocompatibility hemostatic L-cystine dimethyl ester
其他关键词	L-CYSTEINE METABOLISM ; CHITOSAN ; ANTIBACTERIAL ; SCAFFOLDS ; EFFICACY ; CALCIUM ; WOUNDS
摘要	Rapid hemostasis, biosafety, and adaptability to different bleeding sites are the focus of research on hemostatic materials. In this work, an efficient and simple preparation of aldehyde starch hemostatic microspheres (ASHMs) crosslinked with L-cystine dimethyl ester was developed. Through a series of physicochemical parameters and in vitro and in vivo hemostatic properties measurements, the results showed that under the optimal crosslinking degree, ASHMs had a regular and uniform spherical shape, and it had a liquid suction capacity of up to 880%. At the same time, the aldehyde groups on its surface can increase the adhesion and aggregation of blood cells, thereby enhancing the hemostatic effect, which can be considered as a synergistic effect. More importantly, ASHMs have good biocompatibility and minimal intradermal irritation. Taken together?ASHMs could be used as potential novel hemostatic materials for surgical treatment.
资助项目	Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province [WIUCASK19007]; Wenzhou Science and Technology Public Project [ZY2019018]; Wenzhou Institute, University of Chinese Academy of Sciences [ZY2019018]
出版者	WILEY
ISSN	1042-7147
EISSN	1099-1581
卷号	34 期号:5 页码:1608-1621
DOI	10.1002/pat.5995
页数	14
WOS类目	Polymer Science
WOS研究方向	Polymer Science
WOS记录号	WOS:000924253700001
收录类别	SCIE ; EI ; SCOPUS
在线发表日期	2023-01
EI入藏号	20230613555716
EI主题词	Starch
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.9.1 Immunology ; 801.4 Physical Chemistry ; 804.1 Organic Compounds ; 815.1.1 Organic Polymers
URL	查看原文
SCOPUSEID	2-s2.0-85147349262
通讯作者地址	[Liu, Yi]Department of Nephrology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China ; [Yang, Xiao]Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,China ; [Shi, Changcan]Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,China
Scopus学科分类	Polymers and Plastics
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/173039
专题	附属第一医院附属第一医院_肾内科
通讯作者	Liu, Yi; Yang, Xiao; Shi, Changcan
作者单位	1.Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,China; 2.Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province,Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,China; 3.Zhejiang Engineering Research Center for Tissue Repair Materials,Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,China; 4.Department of Nephrology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 肾内科
推荐引用方式 GB/T 7714	Li, Xujian,Chen, Xumin,Ji, Zhixiao,et al. Preparation and evaluation of aldehyde starch hemostatic microspheres crosslinked with L-cystine dimethyl ester for ultrarapid rapid hemostasis[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2023,34(5):1608-1621.
APA	Li, Xujian., Chen, Xumin., Ji, Zhixiao., Pan, Luqi., Liu, Yi., ... & Shi, Changcan. (2023). Preparation and evaluation of aldehyde starch hemostatic microspheres crosslinked with L-cystine dimethyl ester for ultrarapid rapid hemostasis. POLYMERS FOR ADVANCED TECHNOLOGIES, 34(5), 1608-1621.
MLA	Li, Xujian,et al."Preparation and evaluation of aldehyde starch hemostatic microspheres crosslinked with L-cystine dimethyl ester for ultrarapid rapid hemostasis".POLYMERS FOR ADVANCED TECHNOLOGIES 34.5(2023):1608-1621.