Elevated serum uric acid level is associated with adverse reproductive outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization or intracytoplasmic sperm injection embryo transfer cycles: a retrospective cohort study

doi:10.1016/j.ajog.2022.11.1287

科研成果详情

题名	Elevated serum uric acid level is associated with adverse reproductive outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization or intracytoplasmic sperm injection embryo transfer cycles: a retrospective cohort study
作者	Yang, Haiyan1; Wang, Guiquan 2; Liu, Chang 1; Ding, Lin 3; Li, Yan1; Chen, Yi 4; Teng, Yili1; Xu, Zhihui1; Ye, Zhenhong 5,6,7,8; Zhao, Yue 5,6,7,8; Mu, Liangshan 9
发表日期	2023-03
发表期刊	American journal of obstetrics and gynecology 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Research Support, Non-U.S. Gov't
关键词	live birth low birthweight polycystic ovary syndrome reproductive outcomes uric acid
其他关键词	PREGNANCY COMPLICATIONS ; RISK ; METAANALYSIS ; DYSFUNCTION ; CRITERIA ; LINK
摘要	Serum uric acid levels are elevated in polycystic ovary syndrome, however, the relationship between serum uric acid level and reproductive outcomes in women with polycystic ovary syndrome remains unclear., This study aimed to investigate the association between serum uric acid level and the reproductive outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization or intracytoplasmic sperm injection embryo transfer cycles., This was a retrospective cohort study performed at a university-affiliated reproductive medicine center. A total of 1903 women with polycystic ovary syndrome undergoing their first in vitro fertilization or intracytoplasmic sperm injection embryo transfer cycles between January 2010 and January 2021 were initially included. The trends for reproductive outcomes in polycystic ovary syndrome across quartiles of serum uric acid levels were assessed. A logistic regression analysis was performed to obtain the odds ratios for in vitro fertilization outcomes based on the quartiles of serum uric acid with or without adjusting for potential confounding variables. Using generalized additive models, serum uric acid was further treated as its original continuous property to visualize its nonlinear relationship with in vitro fertilization outcomes. The live birth rate was the main outcome., {AbstractText=After exclusions, a total of 883 women with polycystic ovary syndrome with their first fresh-embryo transfer cycles were included. In quartiles of serum uric acid levels, there was a significant decreasing trend in the live birth rate from the lowest quartile (Q1: 61.8%) to the highest (Q4: 45.9%) (Ptrend=.002). The percentage of low birthweight increased from Q1 (22.3%) to Q4 (31.7%) (Ptrend=.049). Compared with those in Q1, women in Q4 showed a significant lower probability of live birth and clinical pregnancy and a higher risk for low birthweight (all P<.05). Both the unadjusted and adjusted generalized additive models indicated that as the serum uric acid level increased, the probability of clinical pregnancy and the live birth rate exhibited an overall decreasing profile, and the risk for low birthweight showed an increasing profile.}, An elevated serum uric acid level is associated with decreased probabilities of live birth and clinical pregnancy and an increased risk for low birthweight in women with polycystic ovary syndrome. However, these associations may be confounded by other factors and more well-designed studies are needed to confirm these findings in the future.
资助项目	National Natural Science Foundation of China [82001503]; Wenzhou Municipal Science and Technology Bureau Foundation of Wenzhou, Zhejiang, China [Y20220055]; Health Department of Zhejiang province [2021KY785]
出版者	MOSBY-ELSEVIER
ISSN	0002-9378
EISSN	1097-6868
卷号	228 期号:3 页码:324.e1-324.e10
DOI	10.1016/j.ajog.2022.11.1287
页数	10
WOS类目	Obstetrics & Gynecology
WOS研究方向	Obstetrics & Gynecology
WOS记录号	WOS:000943284500001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-02
URL	查看原文
PubMed ID	36403859
SCOPUSEID	2-s2.0-85145313437
通讯作者地址	[Mu, Liangshan]Reproductive Medicine Center,Zhongshan Hospital,Fudan University,Shanghai,China
Scopus学科分类	Obstetrics and Gynecology
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172933
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院附属第一医院_生殖医学中心
通讯作者	Mu, Liangshan
作者单位	1.Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Center for Reproductive Medicine,Women and Children's Hospital,School of Medicine,Xiamen University,Xiamen,China; 3.Department of Endocrinology and Metabology,The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital,Jinan,China; 4.The First School of Medicine,Wenzhou Medical University,Wenzhou,China; 5.Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing,China; 6.National Clinical Research Center for Obstetrics and Gynecology,Peking University Third Hospital,Beijing,China; 7.Key Laboratory of Assisted Reproduction,Ministry of Education,Beijing,China; 8.Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology,Beijing,China; 9.Reproductive Medicine Center,Zhongshan Hospital,Fudan University,Shanghai,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 生殖医学中心
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yang, Haiyan,Wang, Guiquan,Liu, Chang,et al. Elevated serum uric acid level is associated with adverse reproductive outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization or intracytoplasmic sperm injection embryo transfer cycles: a retrospective cohort study[J]. American journal of obstetrics and gynecology,2023,228(3):324.e1-324.e10.
APA	Yang, Haiyan., Wang, Guiquan., Liu, Chang., Ding, Lin., Li, Yan., ... & Mu, Liangshan. (2023). Elevated serum uric acid level is associated with adverse reproductive outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization or intracytoplasmic sperm injection embryo transfer cycles: a retrospective cohort study. American journal of obstetrics and gynecology, 228(3), 324.e1-324.e10.
MLA	Yang, Haiyan,et al."Elevated serum uric acid level is associated with adverse reproductive outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization or intracytoplasmic sperm injection embryo transfer cycles: a retrospective cohort study".American journal of obstetrics and gynecology 228.3(2023):324.e1-324.e10.