circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia

doi:10.1515/med-2023-0645

科研成果详情

题名	circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia
作者	Ren, Jinlian1; Cai, Jing 2
发表日期	2023-03-01
发表期刊	Open medicine (Warsaw, Poland) 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Article
关键词	GPR4 circ_0014736 miR-942-5p preeclampsia
其他关键词	BIOGENESIS ; EXPRESSION ; MIGRATION ; RECEPTOR
摘要	Previous studies have indicated that the development of preeclampsia (PE) involves the regulation of circular RNA (circRNA). However, the role of hsa_circ_0014736 (circ_0014736) in PE remains unknown. Thus, the study proposes to reveal the function of circ_0014736 in the pathogenesis of PE and the underlying mechanism. The results showed that circ_0014736 and GPR4 expression were significantly upregulated, while miR-942-5p expression was downregulated in PE placenta tissues when compared with normal placenta tissues. circ_0014736 knockdown promoted the proliferation, migration, and invasion of placenta trophoblast cells (HTR-8/SVneo) and inhibited apoptosis; however, circ_0014736 overexpression had the opposite effects. circ_0014736 functioned as a sponge for miR-942-5p and regulated HTR-8/SVneo cell processes by interacting with miR-942-5p. Additionally, GPR4, a target gene of miR-942-5p, was involved in miR-942-5p-mediated actions in HTR-8/SVneo cells. Moreover, circ_0014736 stimulated GPR4 production through miR-942-5p. Collectively, circ_0014736 inhibited HTR-8/SVneo cell proliferation, migration, and invasion and induced cell apoptosis through the miR-942-5p/GPR4 axis, providing a possible target for the treatment of PE.
出版者	DE GRUYTER POLAND SP Z O O
ISSN	2391-5463
卷号	18 期号:1
DOI	10.1515/med-2023-0645
页数	14
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:000941533800001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	36874362
SCOPUSEID	2-s2.0-85149288859
通讯作者地址	[Cai, Jing]Department of Pathology,Shanghai Jiading District Anting Hospital,No. 1060 Hejing Road, Anting Town, Jiading District,Shanghai,China
Scopus学科分类	Medicine (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172922
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学
通讯作者	Cai, Jing
作者单位	1.Department of Obstetrics,Zhuji Affiliated Hospital of Wenzhou Medical University,Shaoxing,Zhejiang,China; 2.Department of Pathology,Shanghai Jiading District Anting Hospital,No. 1060 Hejing Road, Anting Town, Jiading District,Shanghai,China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学
推荐引用方式 GB/T 7714	Ren, Jinlian,Cai, Jing. circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia[J]. Open medicine (Warsaw, Poland),2023,18(1).
APA	Ren, Jinlian, & Cai, Jing. (2023). circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia. Open medicine (Warsaw, Poland), 18(1).
MLA	Ren, Jinlian,et al."circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia".Open medicine (Warsaw, Poland) 18.1(2023).