Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity

doi:10.3390/jcm12041471

科研成果详情

题名	Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity
作者	Chen, Jiahao 1; Chen, Yiting2; Lin, Yisi1; Long, Jingfang1; Chen, Yufeng 3; He, Jincai1; Huang, Guiqian1
发表日期	2023-02
发表期刊	Journal of clinical medicine 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	acute ischemic stroke bilirubin hemorrhagic transformation mechanical thrombectomy predictor
其他关键词	ACUTE ISCHEMIC-STROKE ; TISSUE-PLASMINOGEN ACTIVATOR ; BLOOD-BRAIN-BARRIER ; OXIDATION-PRODUCTS ; HEME OXYGENASE-1 ; SUBARACHNOID HEMORRHAGE ; INTRAVENOUS ALTEPLASE ; THROMBOLYTIC THERAPY ; ACUTE HYPERGLYCEMIA ; SERUM BILIRUBIN
摘要	Hemorrhagic transformation (HT) is a severe complication in patients with acute ischemic stroke (AIS). This study was performed to explore and validate the relation between bilirubin levels and spontaneous HT (sHT) and HT after mechanical thrombectomy (tHT)., The study population consisted of 408 consecutive AIS patients with HT and age- and sex-matched patients without HT. All patients were divided into quartiles according to total bilirubin (TBIL) level. HT was classified as hemorrhagic infarction (HI) and parenchymal hematoma (PH) based on radiographic data., {AbstractText=In this study, the baseline TBIL levels were significantly higher in the HT than non-HT patients in both cohorts (p < 0.001). Furthermore, the severity of HT increased with increasing TBIL levels (p < 0.001) in sHT and tHT cohorts. The highest quartile of TBIL was associated with HT in sHT and tHT cohorts (sHT cohort: OR = 3.924 (2.051-7.505), p < 0.001; tHT cohort: OR = 3.557 (1.662-7.611), p = 0.006).}, Our results suggest that an increased TBIL is associated with a high risk of patients with sHT and tHT, and that TBIL is more suitable as a predictor for sHT than tHT. These findings may help to identify patients susceptible to different types and severity of HT.
资助项目	Wenzhou Municipal Sci-Tech Bureau Program[Y20210166];National Natural Science Foundation of China[81873799];
出版者	MDPI
ISSN	2077-0383
EISSN	2077-0383
卷号	12 期号:4
DOI	10.3390/jcm12041471
页数	15
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:000945139600001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	36836007
SCOPUSEID	2-s2.0-85148935705
通讯作者地址	[He, Jincai]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Huang, Guiqian]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Medicine (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172838
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科外国语学院附属第一医院
通讯作者	He, Jincai; Huang, Guiqian
作者单位	1.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.School of Foreign Language Studies,Wenzhou Medical University,Wenzhou,325000,China; 3.Department of General Practice,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Jiahao,Chen, Yiting,Lin, Yisi,et al. Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity[J]. Journal of clinical medicine,2023,12(4).
APA	Chen, Jiahao., Chen, Yiting., Lin, Yisi., Long, Jingfang., Chen, Yufeng., ... & Huang, Guiqian. (2023). Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity. Journal of clinical medicine, 12(4).
MLA	Chen, Jiahao,et al."Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity".Journal of clinical medicine 12.4(2023).