Optimal time point for neutrophil-to-lymphocyte ratio to predict stroke-associated pneumonia

doi:10.1007/s10072-023-06654-7

科研成果详情

题名	Optimal time point for neutrophil-to-lymphocyte ratio to predict stroke-associated pneumonia
作者	Chen, Liu-Zhu 1; Luan, Xiao-Qian1,2; Wu, Shu-Zhen3; Xia, Hu-Wei2; Lin, Yi-Si1; Zhan, Lu-Qian1; He, Jin-Cai1
发表日期	2023-07
发表期刊	Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Lymphocyte Neutrophil Pneumonia Prognosis Stroke Thrombolysis
其他关键词	ACUTE ISCHEMIC-STROKE ; MEDICAL COMPLICATIONS ; RISK-FACTORS ; OPEN-LABEL ; MORTALITY ; INFECTION ; DYSPHAGIA ; THROMBOLYSIS ; DIAGNOSIS ; OUTCOMES
摘要	This study aimed at the population receiving thrombolytic therapy and to explore the optimal time point for neutrophil-to-lymphocyte ratio (NLR) in predicting stroke-associated pneumonia (SAP)., We assessed patients undergoing intravenous thrombolysis (IVT) for acute ischemic stroke. Blood parameters were sampled before thrombolysis (within 30 min after admission) and within 24-36 h after thrombolysis, respectively. The primary outcome measure was the occurrence of SAP. Multivariate logistic regression analysis was performed to analyze the association between admission blood parameters and the event of SAP. We also used receiver operating characteristic (ROC) curve analysis to assess the discriminative ability of blood parameters measured at different times in predicting SAP., Among the 388 patients, SAP occurred in 60 (15%) patients. Multivariate logistic regression analysis showed that NLR was significantly associated with SAP (NLR before IVT: aOR = 1.288; 95%CI = 1.123-1.476; p < 0.001; NLR after IVT: (aOR = 1.127, 95%CI = 1.017-1.249; p = 0.023). The ROC curve showed that the predictive ability of NLR after IVT was better than NLR before IVT, not only in predicting the occurrence of SAP but also in predicting short-term and long-term functional outcomes, hemorrhagic transformation, and 1-year mortality., Increased NLR measured within 24-36 h after IVT has a significant predictive effect on the occurrence of SAP and can be used to predict short-term and long-term poor functional outcomes, hemorrhagic transformation, and 1-year mortality.
资助项目	National Natural Science Foundation of China[81873799];Wenzhou Municipal Science and Technology Bureau[Y2020421]
出版者	SPRINGER-VERLAG ITALIA SRL
ISSN	1590-1874
EISSN	1590-3478
卷号	44 期号:7 页码:2431-2442
DOI	10.1007/s10072-023-06654-7
页数	12
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000950643600001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-02
URL	查看原文
PubMed ID	36808310
SCOPUSEID	2-s2.0-85148431481
通讯作者地址	[He, Jin-Cai]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,325000,China
Scopus学科分类	Dermatology;Neurology (clinical);Psychiatry and Mental Health
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172796
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科附属第一医院医院管理处_司法鉴定中心（挂靠）卓越中心_老年研究院
通讯作者	He, Jin-Cai
作者单位	1.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,325000,China; 2.Key Laboratory of Alzheimer’s Disease of Zhejiang Province,Institute of Aging,Wenzhou Medical University,Wenzhou,Zhejiang,China; 3.Judicial Expertise Center of Wenzhou Medical University,Wenzhou,Zhejiang,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Liu-Zhu,Luan, Xiao-Qian,Wu, Shu-Zhen,et al. Optimal time point for neutrophil-to-lymphocyte ratio to predict stroke-associated pneumonia[J]. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology,2023,44(7):2431-2442.
APA	Chen, Liu-Zhu., Luan, Xiao-Qian., Wu, Shu-Zhen., Xia, Hu-Wei., Lin, Yi-Si., ... & He, Jin-Cai. (2023). Optimal time point for neutrophil-to-lymphocyte ratio to predict stroke-associated pneumonia. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 44(7), 2431-2442.
MLA	Chen, Liu-Zhu,et al."Optimal time point for neutrophil-to-lymphocyte ratio to predict stroke-associated pneumonia".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 44.7(2023):2431-2442.