Agonist long protocol improves outcomes of vitrified-warmed embryo transfer in repeatedly thin endometrium

doi:10.1016/j.rbmo.2022.12.003

科研成果详情

题名	Agonist long protocol improves outcomes of vitrified-warmed embryo transfer in repeatedly thin endometrium
作者	Wang, Peiyu; Yang, Haiyan; Chen, Zhuo; Chen, Ya; Jin, Congcong; Yu, Rong; Lin, Jia; Chen, Qianqian; Huang, Xuefeng
发表日期	2023-03
发表期刊	Reproductive biomedicine online 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Follicular stimulation Frozen-thawed embryo transfer Gonadotrophin-releasing hormone agonist Human menopausal gonadotrophin Thin endometrium
其他关键词	IN-VITRO FERTILIZATION ; TRANSFER CYCLES ; FRESH ; THICKNESS ; GONADOTROPIN ; RECEPTIVITY ; PREGNANCIES ; INDUCTION
摘要	Does follicular stimulation using human menopausal gonadotrophin (HMG) after pituitary down-regulation by a GnRH agonist improve endometrial thickness (EMT) and clinical outcomes of frozen-thawed embryo transfer (FET; using vitrified-warmed embryos) in women with thin endometrium after intensified oestrogen administration (IOA)?, This was a retrospective study. A total of 627 patients attempted 683 FET cycles with at least one previous history of thin endometrium. None of the cycles reached over 7 mm EMT after using oral and vaginal oestradiol for more than 21 days (IOA protocol). A total of 129 cycles proceeded with FET, 305 cycles were cancelled, and 249 cycles involved administration of HMG following GnRH agonist pituitary down-regulation (GnRH agonist + HMG protocol) for further endometrial preparation., EMT became significantly greater (7.18 ± 1.14 mm versus 6.13 ± 0.63 mm, P < 0.001) using GnRH agonist + HMG compared with previous IOA cycles, but this was not related to serum oestrogen concentrations. A total of 213 cycles after the GnRH agonist + HMG protocol proceeded with FET, showing a significantly increased clinical pregnancy rate, implantation rate and live birth rate compared with those after IOA., The GnRH agonist + HMG protocol for endometrial preparation in FET cycles improves EMT in women with a thin endometrium after IOA and showed significantly better clinical outcomes than IOA. The authors suggest that the GnRH agonist + HMG protocol should be used for EMT that is less than 7 mm after there has been no optimal response to IOA.
资助项目	National Natural Science Foundation of China[81901551];Wenzhou Science and Technology Bureau[Y2020482];
出版者	ELSEVIER SCI LTD
ISSN	1472-6483
EISSN	1472-6491
卷号	46 期号:3 页码:527-535
DOI	10.1016/j.rbmo.2022.12.003
页数	9
WOS类目	Obstetrics & Gynecology ; Reproductive Biology
WOS研究方向	Obstetrics & Gynecology ; Reproductive Biology
WOS记录号	WOS:000976513800001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-03
URL	查看原文
PubMed ID	36604214
SCOPUSEID	2-s2.0-85146007270
通讯作者地址	[Huang, Xuefeng]Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Reproductive Medicine;Obstetrics and Gynecology;Developmental Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172696
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心附属第一医院
通讯作者	Huang, Xuefeng
作者单位	Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 生殖医学中心
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 生殖医学中心
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Peiyu,Yang, Haiyan,Chen, Zhuo,et al. Agonist long protocol improves outcomes of vitrified-warmed embryo transfer in repeatedly thin endometrium[J]. Reproductive biomedicine online,2023,46(3):527-535.
APA	Wang, Peiyu., Yang, Haiyan., Chen, Zhuo., Chen, Ya., Jin, Congcong., ... & Huang, Xuefeng. (2023). Agonist long protocol improves outcomes of vitrified-warmed embryo transfer in repeatedly thin endometrium. Reproductive biomedicine online, 46(3), 527-535.
MLA	Wang, Peiyu,et al."Agonist long protocol improves outcomes of vitrified-warmed embryo transfer in repeatedly thin endometrium".Reproductive biomedicine online 46.3(2023):527-535.