MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex

doi:10.1016/j.bbrc.2023.01.053

科研成果详情

题名	MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex
作者	Jiang, Tian1,2; Yang, Yaojuan 2; Wu, Chunping 2; Qu, Chunsheng 2; Chen, Jie-Guang2; Cao, Huateng2
发表日期	2023-03-05
发表期刊	Biochemical and biophysical research communications 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Cortical development Layer-specific gene MicroRNA-218 Morphogenesis Radial migration Satb2
其他关键词	CELL-MIGRATION ; SPECIFICATION ; MECHANISMS ; EXPRESSION ; DYSREGULATION ; CONNECTIVITY ; DISORDERS ; NETWORKS ; INSIGHTS ; IDENTITY
摘要	Neuronal migration and morphogenesis are fundamental processes for cortical development. Their defects may cause abnormities in neural circuit formation and even neuropsychiatric disorders. Many proteins, especially layer-specific transcription factors and adhesion molecules, have been reported to regulate the processes. However, the involvement of non-coding RNAs in cortical development has not been extensively studied. Here, we identified microRNA-218 (miR-218) as a layer V-specific microRNA in mouse brains. Expression of miR-218 was elevated in patients with autism spectrum disorder (ASD) and schizophrenia. We found in this study that miR-218 overexpression in developing mouse cortex led to severe defects in radial migration, morphogenesis, and spatial distribution of the cortical neurons. Moreover, we identified Satb2, an upper-layer marker, as a molecular target repressed by miR-218. These results suggest an underlying mechanism of miR-218 involvement in neuropsychiatric disorders, and the interactions of layer-specific non-coding RNAs and proteins in regulating cortical development.
资助项目	Zhejiang Provincial Natural Science Foundation of China [LQ20H090001]; Zhejiang Provincial Medical and Health Science and Technology Project [2019KY247]; Scienti fic Research Fund of Wenling Science and Technology Bureau [2018C320001]; Zhejiang Provincial Program for the Cultivation of New Health Talents [2020-187, 2021-9]
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
ISSN	0006-291X
EISSN	1090-2104
卷号	647 页码:9-15
DOI	10.1016/j.bbrc.2023.01.053
页数	7
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000925414200001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-01
URL	查看原文
PubMed ID	36708662
SCOPUSEID	2-s2.0-85147455411
通讯作者地址	[Cao, Huateng]null ; [Chen, Jie-Guang]null
Scopus学科分类	Biophysics;Biochemistry;Molecular Biology;Cell Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172534
专题	温州医科大学
通讯作者	Chen, Jie-Guang; Cao, Huateng
作者单位	1.Department of Clinical Laboratory,The Affiliated Wenling Hospital,Wenzhou Medical University,Wenling,317500,China; 2.School of Ophthalmology and Optometry and Eye Hospital,Wenzhou Medical University,State Key Laboratory of Optometry,Ophthalmology and Vision Science,and Zhejiang Provincial Key Laboratory of Optometry and Ophthalmology,270 Xueyuan Road,Wenzhou,325027,China
推荐引用方式 GB/T 7714	Jiang, Tian,Yang, Yaojuan,Wu, Chunping,et al. MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex[J]. Biochemical and biophysical research communications,2023,647:9-15.
APA	Jiang, Tian, Yang, Yaojuan, Wu, Chunping, Qu, Chunsheng, Chen, Jie-Guang, & Cao, Huateng. (2023). MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex. Biochemical and biophysical research communications, 647, 9-15.
MLA	Jiang, Tian,et al."MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex".Biochemical and biophysical research communications 647(2023):9-15.