S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway

doi:10.1016/j.prp.2023.154325

科研成果详情

题名	S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway
作者	Chen, Buran 1; Zheng, Danni1; Liu, Conghui 1; Bhandari, Adheesh 1; Hirachan, Suzita 5; Shen, Cuihua2; Mainali, Sumnima 6; Li, Huihui 1; Jiang, Wenjie1; Xu, Jie 4; Zhang, Xiaohua 1; Tang, Kaifu3; Zhang, Wei 1
发表日期	2023-02
发表期刊	Pathology, research and practice 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Biomarker Migration PI3K/AKT/mTOR pathway Proliferation Thyroid cancer
其他关键词	PHOSPHATIDYLINOSITOL 3-KINASE/AKT ; PROTEIN S100A6 ; UP-REGULATION ; EXPRESSION ; PROLIFERATION ; MIGRATION ; PAPILLARY ; ACTIVATION ; CARCINOMA
摘要	High levels of S100A6 have been associated with progression in some types of human cancers. Cancers related to S100A6 have been reported to include lung cancer, cervical cancer, pancreatic cancer, gastric cancer, colon cancer, etc., but its role in the molecular pathogenesis of these cancers is largely unknown. This study investigated the expression and functional roles of S100A6 in human thyroid cancer. The expression level of S100A6 in thyroid cancer cells was determined by bioinformatics and transcriptomic analysis. Furthermore, the potential functions of S100A6 in tumorigenesis were analyzed by cell proliferation, migration, invasion, and Western blot assays in human thyroid cancer cells. Public database queries revealed high S100A6 expression in thyroid cancer. In addition, we also found that high expression of S100A6 was positively correlated with malignant clinicopathological characteristics of thyroid cancer in The Cancer Genome Atlas database. qPCR results confirmed the high expression of S100A6 in thyroid cancer cells. S100A6 silencing inhibited cell proliferation, migration, and invasion. Western blot assays and response experiments showed that S100A6 promotes cell proliferation and tumorigenicity partly through the PI3K/AKT/mTOR signaling pathway. These results suggest that S100A6 affects the progression of thyroid cancer and can be used as a target in the future treatment of thyroid cancer.
资助项目	Zhejiang Provincial Natural Science Foundation of China [LQ17H260004]
出版者	ELSEVIER GMBH
ISSN	0344-0338
EISSN	1618-0631
卷号	242
DOI	10.1016/j.prp.2023.154325
页数	10
WOS类目	Pathology
WOS研究方向	Pathology
WOS记录号	WOS:000972849500001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2023-01
URL	查看原文
PubMed ID	36680929
SCOPUSEID	2-s2.0-85146553529
通讯作者地址	[Tang, Kaifu]Key Laboratory of Diagnosis and Treatment of Severe Hepatopancreatic Diseases Province,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Pathology and Forensic Medicine;Cell Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172470
专题	附属第一医院_骨科附属第一医院_重症医学科（ICU）第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室
通讯作者	Tang, Kaifu
作者单位	1.Department of Breast Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of Orthopaedics,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.Key Laboratory of Diagnosis and Treatment of Severe Hepatopancreatic Diseases Province,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 4.Department of ICU,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 5.Department of General Surgery,Breast and Thyroid Unit,Tribhuvan University Teaching Hospital,Kathmandu,Nepal; 6.Department of Obstetrics and Gynecology,Kulhudhuffushi Regional Hospital,Kulhudhuffushi,Maldives
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Buran,Zheng, Danni,Liu, Conghui,et al. S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway[J]. Pathology, research and practice,2023,242.
APA	Chen, Buran., Zheng, Danni., Liu, Conghui., Bhandari, Adheesh., Hirachan, Suzita., ... & Zhang, Wei. (2023). S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway. Pathology, research and practice, 242.
MLA	Chen, Buran,et al."S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway".Pathology, research and practice 242(2023).