The association between dietary selenium intake and Hashimoto's thyroiditis among US adults: National Health and Nutrition Examination Survey (NHANES), 2007-2012

doi:10.1007/s40618-022-01987-0

科研成果详情

题名	The association between dietary selenium intake and Hashimoto's thyroiditis among US adults: National Health and Nutrition Examination Survey (NHANES), 2007-2012
作者	Zheng G.1,5; Cai Y.3,5; Guo Y.1,4,5; Song F.1,4,5; Hu Y.6; Li L.7; Zhu L.2,5
发表日期	2023-07
发表期刊	JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access ; Journal Article
关键词	Hashimoto's thyroiditis Dietary selenium intake National health and nutrition examination Survey (NHANES) Thyroid peroxidase antibody Thyroglobulin antibody XGBoost Hashimoto’s thyroiditis
其他关键词	AUTOIMMUNE-THYROIDITIS ; SUPPLEMENTATION ; PEROXIDASE ; AUTOANTIBODIES ; ANTIBODIES ; DISEASES ; CANCER ; NEWS
摘要	Background Selenium has been shown to influence the pathological processes and physiological functions of thyroid. Although growing evidence has shown that selenium can improve the treatment of Hashimoto's thyroiditis (HT), there is a need to evaluate the association between dietary selenium intake and HT in a large cross-sectional study. This study explored the association between dietary selenium intake and HT based on the National Health reand Nutrition Examination Survey (NHANES) database (2007-2012). Methods A total of 8756 of 30,442 participants were included in the study. Dietary selenium intake was the independent variable, while HT was the dependent variable. In addition, the relative importance of the selected variables was determined using the XGBoost model. A smooth curve was constructed based on the fully adjusted model to investigate the potential linear relationship between dietary selenium intake and HT. Smooth curves were also constructed to explore the linear/non-linear relationship between dietary selenium intake and thyroid peroxidase antibody (TPOAb)/ thyroglobulin antibody (TgAb). Results The mean age of the enrolled participants was 44.35 years (& PLUSMN; 20.92). The risk of HT was significantly reduced by a 35% per-unit increase in dietary selenium intake after fully adjusting for covariates according to the model (log2-transformed data; OR 0.65; 95% CI 0.51, 0.83). The XGBoost model revealed that dietary selenium intake was the most important variable associated with Hashimoto's thyroiditis. Dietary selenium intake (Log2-transformed) was negatively correlated with TPOAb levels [- 16.42 (- 22.18, - 10.65), P < 0.0001], while a non-linear relationship was observed between dietary selenium intake and TgAb with an inflection point of 6.58 (95.67 mu g, Log2-transformed). Conclusion Dietary selenium intake is independently and inversely associated with HT risk. Moreover, dietary selenium intake is negatively correlated with TPOAb levels and non-linearly correlated with TGAb levels. Therefore, dietary selenium intake may be a safe and low-cost alternative for the prevention and treatment of HT.
资助项目	National Natural Science Foundation of China; Medical and Health Research Program of Zhejiang Province [82103199]; Zhejiang Province Postdoctoral Research Excellence Funding Project [2021435899, LY19H180004]; Zhejiang Provincial Natural Science Foundation [2023KY420]; First Affiliated Hospital of Wenzhou Medical University [ZJ2021167, FHY2019068]; Lishui Municipal Science and Technology Program [LY23H160024]; [2023GYX05]
出版者	SPRINGER
出版地	NEW YORK
ISSN	0391-4097
EISSN	1720-8386
卷号	46 期号:7 页码:1385-1395
DOI	10.1007/s40618-022-01987-0
页数	11
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000899089600001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2022-12
URL	查看原文
PubMed ID	36515869
SCOPUSEID	2-s2.0-85143900691
通讯作者地址	[Zhu L.]Department of Thyroid Surgery,The Fifth Affiliated Hospital of Wenzhou Medical University,Lishui Central Hospital,Zhejiang Province,Lishui City,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Endocrinology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172338
专题	附属第一医院其他_附属第五医院（丽水市中心医院）
通讯作者	Zhu L.
作者单位	1.Otolaryngology Head and Neck Center,Cancer Center,Department of Head and Neck Surgery,Zhejiang Provincial People’s Hospital,Affiliated People’s Hospital,Hangzhou Medical College,Zhejiang Province,Hangzhou City,China; 2.Department of Thyroid Surgery,The Fifth Affiliated Hospital of Wenzhou Medical University,Lishui Central Hospital,Zhejiang Province,Lishui City,China; 3.Department of Thyroid Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou City,China; 4.Department of Public Health,Zhejiang University School of Medicine,Zhejiang Province,Hangzhou City,China; 5.Key Laboratory of Endocrine Gland Diseases of Zhejiang Province,Zhejiang Province,Hangzhou City,China; 6.Second Clinical Medical College,Zhejiang Chinese Medical University,Zhejiang Province,Hangzhou City,China; 7.School of Information Science and Engineering,Zhejiang Sci-Tech University,Hangzhou,310018,China
通讯作者单位	附属第五医院（丽水市中心医院）
推荐引用方式 GB/T 7714	Zheng G.,Cai Y.,Guo Y.,et al. The association between dietary selenium intake and Hashimoto's thyroiditis among US adults: National Health and Nutrition Examination Survey (NHANES), 2007-2012[J]. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION,2023,46(7):1385-1395.
APA	Zheng G.., Cai Y.., Guo Y.., Song F.., Hu Y.., ... & Zhu L.. (2023). The association between dietary selenium intake and Hashimoto's thyroiditis among US adults: National Health and Nutrition Examination Survey (NHANES), 2007-2012. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 46(7), 1385-1395.
MLA	Zheng G.,et al."The association between dietary selenium intake and Hashimoto's thyroiditis among US adults: National Health and Nutrition Examination Survey (NHANES), 2007-2012".JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 46.7(2023):1385-1395.