Human Albumin-Based Hydrogels for Their Potential Xeno-Free Microneedle Applications

doi:10.1002/mabi.202200463

科研成果详情

题名	Human Albumin-Based Hydrogels for Their Potential Xeno-Free Microneedle Applications
作者	Rong, Xiaona 1,2; Mehwish, Nabila 1,2; Niu, Xueming 1,2; Zhu, Niteng 3; Lee, Bae Hoon 1,2
发表日期	2023-03
发表期刊	MACROMOLECULAR BIOSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	drug delivery system human albumin hydrogels microneedles protein-based biomaterial tissue engineering
其他关键词	HUMAN SERUM-ALBUMIN ; CROSS-LINKED COLLAGEN ; BIODEGRADABLE POLYMER MICRONEEDLES ; SILK FIBROIN MICRONEEDLES ; DRUG-DELIVERY ; BIOMEDICAL APPLICATIONS ; INFRARED-SPECTROSCOPY ; MECHANICAL-PROPERTIES ; STRUCTURAL-ANALYSIS ; RELEASE KINETICS
摘要	Nowadays, hydrogels-based microneedles (MNs) have attracted a great interest owing to their outstanding qualities for biomedical applications. For the fabrication of hydrogels-based microneedles as tissue engineering scaffolds and drug delivery carriers, various biomaterials have been tested. They are required to feature tunable physiochemical properties, biodegradability, biocompatibility, nonimmunogenicity, high drug loading capacity, and sustained drug release. Among biomaterials, human proteins are the most ideal biomaterials for fabrication of hydrogels-based MNs; however, they are mechanically weak and poorly processible. To the best of the knowledge, there are no reports of xeno-free human protein-based MNs so far. Here, human albumin-based hydrogels and microneedles for tissue engineering and drug delivery by using relatively new processible human serum albumin methacryloyl (HSAMA) are engineered. The resultant HSAMA hydrogels display tunable mechanical properties, biodegradability, and good biocompatibility. Moreover, the xeno-free HSAMA microneedles display a sustained drug release profile and significant mechanical strength to penetrate the model skin. In vitro, they also show good biocompatibility and anticancer efficacy. Sustainable processible human albumin-based biomaterials may be employed as a xeno-free platform in vivo for tissue engineering and drug delivery in clinical trials in the future.
资助项目	Natural Science Foundation of China; Wenzhou Institute, University of Chinese Academy of Sciences; Zhejiang Provincial Natural Science Foundation of China; [32171316]; [WIUCASQD2019003]; [LGF19E030001]
出版者	WILEY-V C H VERLAG GMBH
出版地	WEINHEIM
ISSN	1616-5187
EISSN	1616-5195
卷号	23 期号:3
DOI	10.1002/mabi.202200463
页数	17
WOS类目	Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science
WOS研究方向	Biochemistry & Molecular Biology ; Materials Science ; Polymer Science
WOS记录号	WOS:000905256700001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
在线发表日期	2023-01
EI入藏号	20230113338398
EI主题词	Proteins
EI分类号	461.1 Biomedical Engineering ; 461.2 Biological Materials and Tissue Engineering ; 461.3 Biomechanics, Bionics and Biomimetics ; 461.9.1 Immunology ; 801.2 Biochemistry ; 801.3 Colloid Chemistry ; 804 Chemical Products Generally ; 804.1 Organic Compounds
URL	查看原文
PubMed ID	36563292
SCOPUSEID	2-s2.0-85145415830
通讯作者地址	[Mehwish, Nabila]Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province,Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,325011,China ; [Lee, Bae Hoon]Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province,Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,325011,China
Scopus学科分类	Biotechnology;Bioengineering;Biomaterials;Polymers and Plastics;Materials Chemistry
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172216
专题	眼视光学院（生物医学工程学院）、附属眼视光医院仁济学院_眼视光、生物医学工程学部
通讯作者	Mehwish, Nabila; Lee, Bae Hoon
作者单位	1.Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province,Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,325011,China; 2.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Zhejiang,Wenzhou,325000,China; 3.Wenzhou Medical University,School of Biomedical Engineering,Zhejiang,Wenzhou,325000,China
推荐引用方式 GB/T 7714	Rong, Xiaona,Mehwish, Nabila,Niu, Xueming,et al. Human Albumin-Based Hydrogels for Their Potential Xeno-Free Microneedle Applications[J]. MACROMOLECULAR BIOSCIENCE,2023,23(3).
APA	Rong, Xiaona, Mehwish, Nabila, Niu, Xueming, Zhu, Niteng, & Lee, Bae Hoon. (2023). Human Albumin-Based Hydrogels for Their Potential Xeno-Free Microneedle Applications. MACROMOLECULAR BIOSCIENCE, 23(3).
MLA	Rong, Xiaona,et al."Human Albumin-Based Hydrogels for Their Potential Xeno-Free Microneedle Applications".MACROMOLECULAR BIOSCIENCE 23.3(2023).