The relationship between serum gamma-glutamyltransferase (GGT) and diabetic nephropathy in patients with type 2 diabetes mellitus: a cross-sectional study

doi:10.1007/s10238-023-00991-9

科研成果详情

题名	The relationship between serum gamma-glutamyltransferase (GGT) and diabetic nephropathy in patients with type 2 diabetes mellitus: a cross-sectional study
作者	Dai, Huifang1; Zhu, Lielie 2; Pan, Bilin1; Li, Hai 1; Dai, ZhiJuan 1; Su, Xiaoyou1
发表日期	2023-01-11
发表期刊	CLINICAL AND EXPERIMENTAL MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Diabetic nephropathy (DN) gamma-Glutamyltransferase (GGT) Type 2 diabetes mellitus (T2DM) Predictor
其他关键词	GELATINASE-ASSOCIATED LIPOCALIN ; CHRONIC KIDNEY-DISEASE ; INSULIN-RESISTANCE ; RISK ; BIOMARKERS ; AMINOTRANSFERASE ; ASSOCIATION ; PATHWAYS ; CHINESE ; MARKERS
摘要	The relationship between serum gamma-glutamyltransferase (GGT) and renal dysfunction is controversial. In this study, we examined the relationship of serum GGT to diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). A total of 577 patients with T2DM were enrolled and their basic information and laboratory data were collected and analyzed. The prevalence of DN increased with the elevated serum GGT tertiles. The level of serum GGT in the DN group was higher than in the non-DN groups. Multivariate logistic analysis showed that high GGT was independent risks for DN (OR = 1.041, 95% CIs 1.023-1.059). And the OR of log-transformed serum GGT for DN was 6.190 (95% CIs 4.248-9.021). The OR of DN across increasing tertiles of serum GGT were 1.00, 3.288 (1.851-5.840), and 5.059 (2.620-9.769) (P for trend < 0.001). Stratified receiver operating characteristic (ROC) analysis by gender showed that the area under ROC curve (AUC) value for GGT was 0.781 (0.732-0.825, P < 0.05) in male and was 0.817 (0.761-0.864, P < 0.05) in female. Compared with female, GGT in male showed lower sensitivity (52.86% vs. 82.05%) and higher specificity (90.32% vs. 55.26%). And the AUC value for GGT was greater than creatinine (Cr) and estimated glomerular filtration rate (eGFR) in male and smaller than Cr and eGFR in female, respectively. In Conclusion, there was an independently positive relationship between serum GGT levels and DN, which suggested that elevated GGT was a potential indicator for risk of DN. There were gender differences in the predictive property of GGT for DN.
资助项目	Wenzhou Science and Technology Plan Project [Y20180685]; Rehabilitation Medicine, Provincial Key Disciplines of Zhejiang in Wenzhou Hospital of Traditional Chinese Medicine
出版者	SPRINGER-VERLAG ITALIA SRL
出版地	MILAN
ISSN	1591-8890
EISSN	1591-9528
卷号	23 期号:7 页码:3619-3630
DOI	10.1007/s10238-023-00991-9
页数	12
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:000912231100001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-01
URL	查看原文
PubMed ID	36630069
SCOPUSEID	2-s2.0-85146309556
通讯作者地址	[Zhu, Lielie]Department of Rehabilitation,Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Traditional Chinese Medicine,No.9 Jiaowei Road, Zhejiang,Wenzhou,325000,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172179
专题	第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Zhu, Lielie
作者单位	1.Department of Endocrinology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,No.109, Xueyuanxi Road, Zhejiang,Wenzhou,325000,China; 2.Department of Rehabilitation,Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Traditional Chinese Medicine,No.9 Jiaowei Road, Zhejiang,Wenzhou,325000,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Dai, Huifang,Zhu, Lielie,Pan, Bilin,et al. The relationship between serum gamma-glutamyltransferase (GGT) and diabetic nephropathy in patients with type 2 diabetes mellitus: a cross-sectional study[J]. CLINICAL AND EXPERIMENTAL MEDICINE,2023,23(7):3619-3630.
APA	Dai, Huifang, Zhu, Lielie, Pan, Bilin, Li, Hai, Dai, ZhiJuan, & Su, Xiaoyou. (2023). The relationship between serum gamma-glutamyltransferase (GGT) and diabetic nephropathy in patients with type 2 diabetes mellitus: a cross-sectional study. CLINICAL AND EXPERIMENTAL MEDICINE, 23(7), 3619-3630.
MLA	Dai, Huifang,et al."The relationship between serum gamma-glutamyltransferase (GGT) and diabetic nephropathy in patients with type 2 diabetes mellitus: a cross-sectional study".CLINICAL AND EXPERIMENTAL MEDICINE 23.7(2023):3619-3630.